DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and Itga8

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	XP_006497538.1	Gene:	Itga8 / 241226	MGIID:	109442	Length:	1079	Species:	Mus musculus

Alignment Length:	1173	Identity:	293/1173 - (24%)
Similarity:	477/1173 - (40%)	Gaps:	228/1173 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SPKHLKFHINQTR--------SSYFGYTLVI-----RQTSIIVGAPRAQSTLESQRTINETGAIY 88
            ||..|.|:::..:        .|||||:|..     |..|::||||:|.:   ||..|.|.||:|
Mouse    32 SPACLAFNLDVDKLTVYSGPEGSYFGYSLDFYIPDARTASVLVGAPKANT---SQPDIVEGGAVY 93

  Fly    89 RC---SLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLGGSMDGGTKDTDKLLVCAPRFYA 150
            .|   |..:..|.....|:..|.....:......|.|..||.|.::   .....|::.|||.::.
Mouse    94 YCPWPSERSAQCKQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATV---RAHKGKVVACAPLYHW 155

  Fly   151 PSSRDNHLH---GVCYWVNNTVASTPQHVTRISPLRLKSEQVKEEDNGN-KASF---FYIMGELG 208
            .:.:.|...   |.||......::..:|    ||.|  :.....|..|. :|.|   ||..|:|
Mouse   156 RTLKPNPAKDPVGTCYVAIQNFSAYAEH----SPCR--NSNADPEGQGYCQAGFSLDFYKNGDL- 213

  Fly   209 LSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEH 273
                        ::|.||...|:|.||.....|.:.|      .:.|.:.|........|..|..
Mouse   214 ------------IVGGPGSFYWQGQVITVSIADIIAN------YSFKDILRKLAAEKQTDVAPAS 260

  Fly   274 YAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKY 338
            |             :|||.||:|::|.|...:..:|  ||..|:..:..|  |:..:....:...
Mouse   261 Y-------------DDSYLGYSVAAGEFTGDSQQEL--VAGIPRGAQNFG--YVSIINSTDMTFI 308

  Fly   339 HVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDN----GAIYVFINKGFFNFERQ 399
            ..|.|||...||||:|:..|:|.||..|::|.||.....:...|    |.:|:::......|:..
Mouse   309 QNFTGEQMASYFGYTVVVSDVNNDGMDDILVGAPLFMEREFESNPREVGQVYLYLQASALLFQDP 373

  Fly   400 ILRSPVETMARFGTALSRLGDINHDGYNDVAVGAPFAG---NGTVFIYLGSENGLRDQPSQRLDA 461
            .:.:..||..|||::::.|||:|.|||||:|:|.||||   .|.|.||.|:..||..:|||.|.
Mouse   374 QVLTGTETFGRFGSSVAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNPRGLHSKPSQVLQ- 437

  Fly   462 PSQQPSKYGSHM----FGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESR 522
                 ..:||..    ||..|...:|||.|.:.|..:||.....|.:|||.|||.|.|.:.....
Mouse   438 -----GIWGSQTIPSGFGFSLRGDADIDKNDYPDLLVGAFGKGKVAVYRARPVVTVDAQLLLHPM 497

  Fly   523 EIKPEQEKVKI------TACYRL---------STTSTDKLVQEQELAIRIAMDKQLKRVKFTQTQ 572
            .|..|.:..:|      .||:.:         |.::|..|:.|.:|.. :.....:||..|....
Mouse   498 IINLENKTCQIPEFPTPVACFSVRVCASIAGQSISNTIALLAEVQLDF-LKQKGAIKRTLFLHNH 561

  Fly   573 TNEISFK--VNANFGEQCRDF------ETQVRYSEKDIFTPIDLEMHYELTKKVPDS--EEFCET 627
            .:..:|.  :.......|:||      ||:.|    |..:||::.::|.|    .||  ::..|.
Mouse   562 QSHFTFPFVMKQQKSLHCQDFMVYLRDETEFR----DKLSPINISLNYSL----DDSTFKDSLEV 618

  Fly   628 CAIVDPTEPKVSTQNIIFSTGCATD-VCTADLQLRSKDVSPTYILGSADTLRLNYEITNIGETAY 691
            ..|::.....|.|:.......|..| :|..||:|.::......|:|..:.|.|.....|.||.||
Mouse   619 KPILNHYRDNVVTEQAHILVDCGEDNLCVPDLKLSARPDKHQIIIGDENHLMLIINARNEGEGAY 683

  Fly   692 LPQFNVTSTSRLAFAQV--------PGNCKV----VDAVMVCDLNRGRPLAKGDTDSVTISFDVS 744
            ..:..|.......:..:        |.:|:.    |..::||||  |.|:..|...|:.:.|.|.
Mouse   684 EAELFVIIPEEADYVGIERNNKGLRPLSCEYKMENVTRMVVCDL--GNPMVTGTNFSLGLRFAVP 746

  Fly   745 QLSGQSLIIHAEV-FSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNSAE---- 804
            :|...::.|:.:: ..:..:.||..|.:...|.:....:::..|.....||.|..::...|
Mouse   747 RLEKTNMSINFDLQIRSSNKDNPDSNFERVQINITAIAQVEIRGVSHPPQIVLPIHNWEPEKKPH 811

  Fly   805 --------IVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLS 861
                    :.:.||:.:.|||.|....:....|.:   |....::.|.::.:|.
Mouse   812 KEEEVGPLVEHIYELHNIGPSTISDSILDVGWPFS---ARDEFLLYIFHLQTLG----------- 862

  Fly   862 IDLYDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSR 926
             .|..|.|..:                      |.|  ||..:.....|.|:......||.....
Mouse   863 -PLQCQTNPEI----------------------NPQ--DIKPAASPEDTPELSAFLRNATIPHLV 902

  Fly   927 KRRDLKALTANREQYARISNVKAHDLLSDDFK-GKLPVNRTIVFNCRDPEMTICVRAEMRVH-FR 989
            ::||:..:..:|:..|||.|....|.|..... |:|....:.|..         ||:.:..| |.
Mouse   903 RKRDVPVVQLHRQSPARILNCTNIDCLQISCAVGRLGGGESAVLK---------VRSRLWAHTFL 958

  Fly   990 PEKSINLNMRYSV--DLNEVNAILVDPWEYFVILTDLKLQKKGDP--------TSTSFSINRRI- 1043
            .|.|:....:..:  .|...|       :::.:.:.:..:.|..|        .:.|.::...:
Mouse   959 KEISVEETSQEQLVKTLKRKN-------DHYALASLVSFEVKKMPYKEQPAKLPAGSTAVKTSVI 1016

  Fly  1044 --EPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTK--KDEL-DRLVQQNPVE 1103
              .||:     ...:|:|:||::::.|||:|:.::..|:|.|||:|.:  :||: ||....:...
Mouse  1017 WATPNV-----SFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQDEMTDREQLTSDKT 1076

  Fly  1104 PEA 1106
            |||
Mouse  1077 PEA 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	23/59 (39%)
		FG-GAP	350..388	CDD:280083	15/41 (37%)
		Int_alpha	409..459	CDD:214549	28/52 (54%)
		Int_alpha	473..>515	CDD:214549	18/45 (40%)
		Integrin_alpha2	507..829	CDD:285619	83/372 (22%)
Itga8	XP_006497538.1	Int_alpha	53..111	CDD:214549	23/60 (38%)
		Int_alpha	316..>364	CDD:214549	16/47 (34%)
		Int_alpha	382..436	CDD:214549	28/53 (53%)
		Int_alpha	447..491	CDD:214549	18/43 (42%)
		Integrin_alpha2	482..933	CDD:369878	107/500 (21%)
		Integrin_alpha	1051..1065	CDD:334029	6/13 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832056
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740