DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and ITGA11

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_001004439.1	Gene:	ITGA11 / 22801	HGNCID:	6136	Length:	1188	Species:	Homo sapiens

Alignment Length:	1359	Identity:	293/1359 - (21%)
Similarity:	474/1359 - (34%)	Gaps:	496/1359 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 EAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQTS----IIVGAPRAQSTLESQRTINE 83
            :.||...|..|||..          :|:::||||:.....|    ::||||     ||: ....:
Human    21 DTFNMDTRKPRVIPG----------SRTAFFGYTVQQHDISGNKWLVVGAP-----LET-NGYQK 69

  Fly    84 TGAIYRCSLTNGVCSPYVLD--SRGNVDAPYSEYTFDSERKDFQWLGGSMDGGTKDTDKLLVCAP 146
            ||.:|:|.:.:|.|:...|.  :..||          |||||...||.|:....|| :..|.|:|
Human    70 TGDVYKCPVIHGNCTKLNLGRVTLSNV----------SERKDNMRLGLSLATNPKD-NSFLACSP 123

  Fly   147 RFYAPSSRDNHLHGVCYWVNN------TVA----------------------------------- 170
            .:........:..|:|..||:      |||
Human   124 LWSHECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVEVQHFLINI 188

  Fly   171 ----------------------------------------------------------------- 170

Human   189 LKKFYIGPGQIQVGVVQYGEDVVHEFHLNDYRSVKDVVEAASHIEQRGGTETRTAFGIEFARSEA 253

  Fly   171 ---------------------------------STPQHVTR-------------ISPLRLKSEQV 189
                                             |...:|||             |:|....:| :
Human   254 FQKGGRKGAKKVMIVITDGESHDSPDLEKVIQQSERDNVTRYAVAVLGYYNRRGINPETFLNE-I 317

  Fly   190 K----------------------------------EEDNGNKASFFYIMGELGLSAHVADDNTKF 220
            |                                  |..|.|:.||...|.:.|.|:||.:|..
Human   318 KYIASDPDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNETSFGLEMSQTGFSSHVVEDGV-- 380

  Fly   221 LIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKA----LRRTYRDVDSNDYTPEHYAPEIPTP 281
            |:||.|...|.|:|:               ::||..    ||.:|.         :.:..|:...
Human   381 LLGAVGAYDWNGAVL---------------KETSAGKVIPLRESYL---------KEFPEELKNH 421

  Fly   282 GLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDV---RGKSIHKYHVFRG 343
            |       :|.||.|:|..   |:....:|||.||:.| .:|:..:|.:   |..:||:  ..||
Human   422 G-------AYLGYTVTSVV---SSRQGRVYVAGAPRFN-HTGKVILFTMHNNRSLTIHQ--AMRG 473

  Fly   344 EQFGEYFGYSVLAEDLNGDGKTDV-IVSAPQHALEDSHDNGAIYVF-INKGFFNFERQILRSPVE 406
            :|.|.|||..:.:.|::|||.||| :|.||.: ..:..:.|.:||: :.:..|.:...:..|...
Human   474 QQIGSYFGSEITSVDIDGDGVTDVLLVGAPMY-FNEGRERGKVYVYELRQNLFVYNGTLKDSHSY 537

  Fly   407 TMARFGTALSRLGDINHDGYNDVAVGAPFAGN--GTVFIYLGSENGLRDQPSQRLDAPSQQPSKY 469
            ..||||::::.:.|:|.|.||||.||||...|  |.::|:.|....:...|.||:.|.....
Human   538 QNARFGSSIASVRDLNQDSYNDVVVGAPLEDNHAGAIYIFHGFRGSILKTPKQRITASELAT--- 599

  Fly   470 GSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEKVKIT 534
            |...||..:....|::.:|..|.|:|| ...||.|: :.|||:::|::..|     |.:..:...
Human   600 GLQYFGCSIHGQLDLNEDGLIDLAVGA-LGNAVILW-SRPVVQINASLHFE-----PSKINIFHR 657

  Fly   535 ACYRLSTTSTDKLVQEQELAIRIAMDKQLKRVKFTQTQTNEISFKVNANFGEQCRDFETQVRYSE 599
            .|.|....:|.       ||..:..........|   ||..:..:.||...|:        ||:.
Human   658 DCKRSGRDATC-------LAAFLCFTPIFLAPHF---QTTTVGIRYNATMDER--------RYTP 704

  Fly   600 K-------DIFT--PIDLEMHYELTKK----VPDSEEFCETC------AIVDPTE--------PK 637
            :       |.||  .:.|....||.::    |.|:.::.:..      ::.||..        |.
Human   705 RAHLDEGGDRFTNRAVLLSSGQELCERINFHVLDTADYVKPVTFSVEYSLEDPDHGPMLDDGWPT 769

  Fly   638 VSTQNIIFSTGCATDV-CTADLQLRSKDVSPT------------------YILGSADTL------ 677
            ....::.|..||..|. |..||.|.::...||                  |.| |.||.
Human   770 TLRVSVPFWNGCNEDEHCVPDLVLDARSDLPTAMEYCQRVLRKPAQDCSAYTL-SFDTTVFIIES 833

  Fly   678 ---RLNYEIT--NIGETAYLPQFNVTSTSRLAFAQV------PGNCKVVD-----AVMVCDLNRG 726
               |:..|.|  |.||.||....|::.::.|.||.:      .|:.:.|:     ...||:::..
Human   834 TRQRVAVEATLENRGENAYSTVLNISQSANLQFASLIQKEDSDGSIECVNEERRLQKQVCNVSYP 898

  Fly   727 RPLAKGDTDSVTISFDVSQLSGQSLII-HAEV-FSTGYEQNPTDN-RQTNVIGLKEFTEIDASGG 788
            ...||... :..:.|:.|    :|:.: |.|: .:.|.:.|..|: ::.||..|:...:.:|...
Human   899 FFRAKAKV-AFRLDFEFS----KSIFLHHLEIELAAGSDSNERDSTKEDNVAPLRFHLKYEADVL 958

  Fly   789 QTNSQIDLEHYSNSAEIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQA 853
            .|.|. .|.|          ||:|.|.
Human   959 FTRSS-SLSH----------YEVKPNS-------------------------------------- 974

  Fly   854 SYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSM 918
                   |::.||.     :..|......:          ||...:.||       .|.:..|..
Human   975 -------SLERYDG-----IGPPFSCIFRI----------QNLGLFPIH-------GMMMKITIP 1010

  Fly   919 VATASMSR--KRRDLKALTANREQYARISNVKAHDL------LSDDFKGKLPVNRT----IVFNC 971
            :||.|.:|  |.||.....||..     .|:..:..      :.:|.:....:|.:    :..||
Human  1011 IATRSGNRLLKLRDFLTDEANTS-----CNIWGNSTEYRPTPVEEDLRRAPQLNHSNSDVVSINC 1070

  Fly   972 RDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTS 1036
                         .:...|.:.||.::..::.|..:.|:   .::...|:.:..||::    ..|
Human  1071 -------------NIRLVPNQEINFHLLGNLWLRSLKAL---KYKSMKIMVNAALQRQ----FHS 1115

  Fly  1037 FSINRRIEPN-----IISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKK 1090
            ..|.|..:|:     .|||.::..:|||||:.|.:||||||:.:...|:|.|||...::
Human  1116 PFIFREEDPSRQIVFEISKQEDWQVPIWIIVGSTLGGLLLLALLVLALWKLGFFRSARR 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	17/55 (31%)
		FG-GAP	350..388	CDD:280083	14/38 (37%)
		Int_alpha	409..459	CDD:214549	21/51 (41%)
		Int_alpha	473..>515	CDD:214549	14/41 (34%)
		Integrin_alpha2	507..829	CDD:285619	83/392 (21%)
ITGA11	NP_001004439.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	24..85		23/76 (30%)
		Int_alpha	39..>78	CDD:214549	15/44 (34%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	91..151		19/70 (27%)
		vWA_integrins_alpha_subunit	163..341	CDD:238746	8/178 (4%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	355..406		19/67 (28%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	411..461		16/69 (23%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	462..527		24/67 (36%)
		Int_alpha	476..>518	CDD:214549	16/42 (38%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	528..586		20/57 (35%)
		Int_alpha	538..592	CDD:214549	21/53 (40%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	590..650		20/69 (29%)
		Integrin_alpha2	635..1034	CDD:285619	102/510 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142000
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840