DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and pat-2

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_498948.1	Gene:	pat-2 / 176240	WormBaseID:	WBGene00003929	Length:	1226	Species:	Caenorhabditis elegans

Alignment Length:	1316	Identity:	311/1316 - (23%)
Similarity:	498/1316 - (37%)	Gaps:	326/1316 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FPH---IFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQTS-----I 64
            ||.   :.|.||.|::.:..||.         ..|::..|  ....:||||:|......     :
Worm     6 FPRRIGLLLGLLGLLAGVATFNI---------DTKNVVVH--HMAGNYFGYSLDFYHEQKGMPVL 59

  Fly    65 IVGAPRAQSTLESQRTINETGAIYRCSLTNGVCSPYVLDS-RGNVDAPYSEYTFDSERKDFQWLG 128
            :||||.|:|...:...|...||:|.||:....|....:|. :||:......:....|.|..|:.|
Worm    60 VVGAPEAESNNPNLAGIRRPGAVYACSVNRATCREVHVDKMKGNLKKLNGSHLVPIEEKSHQFFG 124

  Fly   129 GSMDGGTKDTDKLLVCAPRFYAPSSRDNHLH--GVCYWVNN------TVASTPQHVTRISPLRLK 185
            .::....|. ||::||||::....|:...:.  |.|::..|      ..:|..|...|....||.
Worm   125 ATVRSNDKH-DKIVVCAPKYTYFYSKFEVIEPVGTCFYAENGFDNAEEFSSCKQEPARHGRHRLG 188

  Fly   186 SEQVKEEDNGNKASFFYIMGELGLSAHV--ADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTA 248
                              .|:.|.||.|  ..:..:..|||||:..|:|::......:..|.|
Worm   189 ------------------YGQCGFSAAVPGKKNQNRVFIGAPGVWYWQGAMFSQNIKNQTDRP-- 233

  Fly   249 SRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVA 313
                             :.:|..:.|             :....||:.::|.||......:  ||
Worm   234 -----------------NTEYGSKEY-------------DHDMMGYSTATGDFDGDGIDDI--VA 266

  Fly   314 TAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQH---- 374
            ..|:.|...|:..::..:.|.:.........|.|:|.|.||...|:|.||:.|:|:..|.:
Worm   267 GVPRGNDLHGKLVLYTSKLKMMINLTDEVSTQHGQYCGGSVAVADVNKDGRDDIIMGCPFYTDYG 331

  Fly   375 ALEDS--------HDNGAIYVFINKGFFNFERQILRSPVETMARFGTALSRLGDINHDGYNDVAV 431
            :::|:        :|.|.:.|.:......|.:||.....:...|||.|::..||:|.||||||.|
Worm   332 SVKDAKTQERKPQYDVGKVIVMLQTAPGVFGKQIAVVGDDQWGRFGHAVAAAGDLNLDGYNDVIV 396

  Fly   432 GAPFAG---NGTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFA 493
            |||:||   .|.|::..||::|:|:.|:|:::..:.......|  ||..|:...|:||||..|.|
Worm   397 GAPYAGKNKQGAVYVIHGSKDGVRELPTQKIEGANIGHGNIKS--FGFSLTGNEDVDGNGMPDIA 459

  Fly   494 IGA---PNAEAVYLYRAYPVVKVHATVKSESREIKPEQE------KVKITACYRLST-------- 541
            :||   .|| ||.|.:  |||.|....:.||..|..|.:      |:...||..::|
Worm   460 VGAWKSGNA-AVLLTK--PVVTVTGQTEPESALISVEDKNCDVDGKLGKQACKHINTCFKYEGKG 521

  Fly   542 -TSTDKLVQEQELAIRIAMDKQL--KRVKFTQTQT-NEISFKVNANFGEQCRD----FETQVRYS 598
             |..|     .|..:|..:|...  .|..|.|... ::.|.||..  |.:.||    .|.:||..
Worm   522 DTPND-----LEFDLRFNLDDHSPEPRAYFLQKDVKSDRSIKVAQ--GSKTRDHPSSIEQRVRLE 579

  Fly   599 E----------------KDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQN-IIFS 646
            :                ||..:||...::|...:.........:....:|.|.| :|.|| |..:
Worm   580 KGRQKCFRHRFFASSTMKDKLSPIHWSVNYTYVESKTGKLRGDKLEPAIDTTVP-LSFQNKINIA 643

  Fly   647 TGCA-TDVCTADLQLRSKDVSPTYILGSAD-TLRLNYEITNIGETAY-------LPQ----FNVT 698
            ..|. .|:|..||::.:......::||:.| |:.:|..:.|.||.:|       :||    ..:.
Worm   644 NNCGKDDLCVPDLKVTAVADREKFLLGTQDNTMLINVTVQNGGEDSYETKLYFDVPQGFEYGGIE 708

  Fly   699 STSRLAFAQVPGNCKVVDA-------VMVCDLNRGRPLAKGDTDS----VTISFDVSQLSGQSLI 752
            |.........|......|.       ...|||  |.||......|    ||.|.|...|:  .:.
Worm   709 SVGGDGSKSAPACSPTSDEPDSDGKWTFACDL--GNPLPANKVVSSVVRVTASSDKPPLA--PIS 769

  Fly   753 IHAEVFSTGYEQNPT--DNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNS----------AEI 805
            |:|.|.|:..|:..|  ||:.|..|.:....::..:|.....|:|....:.:          ..:
Worm   770 INAHVNSSNDEEAHTVADNKVTFTIPVDFKNQLSLNGRSNPEQVDFSMTNKTRVDAFDDNEIGPV 834

  Fly   806 VNN-YEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAII---PIINVTSL-KMQASYDSQLLSIDLY 865
            |:: |:|.:.|||.::..|:..:.|......|....|   |::|..:. :.:......:..::|.
Worm   835 VSHLYQISNRGPSEVDSATLDIFWPSFSTEGGHLLYIITEPVVNPPNKGRCRVKQLQNVNPLNLR 899

  Fly   866 DQNNTMLVVDPV-----------------EVTTTLSGGLERTVITQNRQSYDIHTSGHVH----- 908
            ..|..:....||                 :.|||.|    ::...|:.|....|.||.||
Worm   900 ITNEHVPTEPPVAKTPNEYSREEDDESYEDETTTQS----QSTRHQSTQHQTHHQSGPVHVYEKD 960

  Fly   909 ----------------------------------QTMEVLDTSMVATASMSRKRRDLKALTAN-- 937
                                              ...|..|......|...|.:|:.......
Worm   961 EEKIRQNTGNWQYVEDKKKKGDYEYIPDDQEYDGDDFEEEDDEDFDRAGSKRVKRNPTPKKKKKG 1025

  Fly   938 -------REQYARISNVKAHDLLSD------DFKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFR 989
                   |...||.|:::....||.      |:||  |::|..|    |.....|...|..::
Worm  1026 GEHRGEPRSDKARFSDLREAVKLSKEAGGVVDYKG--PLSRASV----DCNSLRCTHIECDIY-- 1082

  Fly   990 PEKSINLNMRYSVDLNEVNAILVDPWE--YFVILTDLKLQKKGD--------PTSTSFSINRR-- 1042
                         ||.|...:||:.:.  |...|.|.| ...||        .|||.:::..:
Worm  1083 -------------DLKEDEFVLVEIFSRLYTNTLVDEK-NPGGDISSLALARVTSTKYNLPHKPT 1133

  Fly  1043 ------IEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNR----TKKDEL--DR 1095
                  ...|.|:..:...||.|:.:::::.||.:|..:..||::.|||.|    |:..||  ||
Worm  1134 LITAVSTNMNAIASEEGRDLPWWLYLLAILIGLAILILLILLLWRCGFFKRNRPPTEHAELRADR 1198

  Fly  1096 LVQQNPVEPEAENLNS 1111
                   :|.|:..:|
Worm  1199 -------QPNAQYADS 1207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	18/56 (32%)
		FG-GAP	350..388	CDD:280083	13/49 (27%)
		Int_alpha	409..459	CDD:214549	27/52 (52%)
		Int_alpha	473..>515	CDD:214549	21/44 (48%)
		Integrin_alpha2	507..829	CDD:285619	92/397 (23%)
pat-2	NP_498948.1	Int_alpha	39..98	CDD:214549	18/58 (31%)
		Int_alpha	299..359	CDD:214549	16/59 (27%)
		Int_alpha	372..427	CDD:214549	27/54 (50%)
		Int_alpha	440..>462	CDD:214549	10/21 (48%)
		Integrin_alpha2	473..920	CDD:285619	101/460 (22%)
		Integrin_alpha	1178..1192	CDD:278771	5/13 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810