DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and Itga2

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	XP_345157.5	Gene:	Itga2 / 170921	RGDID:	621632	Length:	1178	Species:	Rattus norvegicus

Alignment Length:	1028	Identity:	247/1028 - (24%)
Similarity:	403/1028 - (39%)	Gaps:	263/1028 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 VASTP----------------------QHVTRISPLRLKSEQVKEEDNGNKASFFYIMGELGLSA 211
            :||||                      :|:..|      ...|:..||     |...|.::|.||
  Rat   329 IASTPTERYFFNVADEAALLEKAGTLGEHIFSI------EGTVQGGDN-----FQMEMAQVGFSA 382

  Fly   212 HVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAP 276
            ..:..|...::||.|...|.|:|:               ::||      |..:    ..|:....
  Rat   383 DYSPQNDILMLGAVGAFDWSGTVV---------------QETS------YEHL----IFPKQAFD 422

  Fly   277 EIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVR---GKSIHKY 338
            ::    |..:...|:.||:|::    .|....:.:||.||:|| .:|:..::.|.   ..::.:.
  Rat   423 QV----LQDRNHSSFLGYSVAA----ISTENGVHFVAGAPRAN-YTGQIVLYSVNKHGNVTVIQS 478

  Fly   339 HVFRGEQFGEYFGYSVLAEDLNGDGKTDV-IVSAPQHALEDSHDNGAIYVF-INKGFFNFERQIL 401
            |  ||:|.|.|||..:.:.|::.|..||| :|.||.:..:...:.|.:|:| |.||..| :.|.|
  Rat   479 H--RGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMNDLKKEEGKVYLFTITKGVLN-QHQFL 540

  Fly   402 RSPVET-MARFGTALSRLGDINHDGYNDVAVGAPF--AGNGTVFIYLGSENGLRDQPSQRLDAPS 463
            ..|..| .||||:|::.|.|||.||:|||.||:|.  ..:|.|:||.|.:..:|.:.||::   .
  Rat   541 EGPEGTGNARFGSAIAALSDINMDGFNDVIVGSPVENENSGAVYIYNGHQGTIRTKYSQKI---L 602

  Fly   464 QQPSKYGSHM--FGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLY-RAYPVVKVHATVKSESREIK 525
            .....:.||:  ||..|....|::|:...|.:||| ..:.|.|: ::...|...|:...:...:.
  Rat   603 GSDGAFKSHLQFFGRSLDGYGDLNGDSITDVSIGA-LGQVVQLWSQSVADVATEASFTPDKIILL 666

  Fly   526 PEQEKVKITACYRLSTTSTDKLVQEQELAIRIAM----DKQLKRVK----FTQTQTNEISFKVNA 582
            .::.|:.:..|:|.......   |..::||...|    |:...||.    |.:.....:...:..
  Rat   667 NKEAKITLKLCFRAKFRPPG---QNHQVAILFNMTLDADQYSSRVTSRGIFRENSERFLQKTMVV 728

  Fly   583 NFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTK--KVPDSEEFCETCAIVDPTEPKVSTQNIIF 645
            :..|.|.::...:: ...|:..|:||.:...|.|  ..|..|.:.||          |...:|.|
  Rat   729 SEVENCSEYHISIQ-KPSDVVNPLDLRVDISLEKPGTSPALEAYSET----------VKVFSIPF 782

  Fly   646 STGCATD-VCTADLQLRSKDV----SPTYILGSADTLRLNYEIT--NIGETAYLPQFNVTSTSRL 703
            ...|.:| :|.:||.|..:.:    :..:|: |....||.:.:|  |.||:||........:..|
  Rat   783 YKECGSDGICISDLILDVRQLPALRNQPFIV-SNQNKRLTFSVTLKNRGESAYNTAVLAEFSENL 846

  Fly   704 AFAQ----VPG---NCKVVDA--VMVCDLNRGRPLAKGD---TDSVTISFDVSQLSGQSLIIHAE 756
            .||.    |.|   .|::..:  .:.||:  |.|..|.:   |.::...|::..|..|: .|:.:
  Rat   847 FFASFSMPVDGTEVTCQIGSSQKSVTCDV--GYPALKSEQQVTFTINFDFNLQNLQNQA-AINFQ 908

  Fly   757 VFSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNSAEIVNNYEIKS--NGPSVI 819
            .||...|.|..||..:.::.|....|:              |.:.|..| |.|||.|  |.||||
  Rat   909 AFSESQETNKADNSVSLIVPLLYDAEL--------------HLTRSTNI-NFYEISSDENAPSVI 958

  Fly   820 ---EQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLY-DQNNTMLVVDPVEVT 880
               |.:...|...:  |:...:|.:.:.:||            :.|.|: .:.|.:|.:..::.
  Rat   959 NSVEDIGPEFIFSL--KITAGSAPVSMASVT------------IHIPLHTKEKNPLLYLTGIQT- 1008

  Fly   881 TTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATAS----MSRKRRDLKALTANREQY 941
                                 ..:|.:....|:...::..|||    .|...|.:|.|.......
  Rat  1009 ---------------------DKAGDISCRAEINPLNLPHTASPVSFKSENFRHMKELDCKTTSC 1052

  Fly   942 ARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFRPEKSINLNMR------- 999
            :.:|                                 |...::  |.:.|..||:..|
  Rat  1053 SNVS---------------------------------CWLKDL--HMKAEYFINVTTRVWNRTFA 1082

  Fly  1000 ----YSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPNIISKHQETG-LPIW 1059
                .:|.|.....|.....:.|||                 ..|....|.:|.|..|.. :|..
  Rat  1083 ASTFQTVQLTAAAEIDTHNPQLFVI-----------------EENAVTIPLMIMKPTEKAEVPTG 1130

  Fly  1060 IIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDELDRLVQQNPVE-PEAENLNS 1111
            :||.|:|.|:|||.|:...|:|.|||.|..|.     :.|||.| .|...|||
  Rat  1131 VIIGSIIAGILLLLAMVAGLWKLGFFKRQYKK-----MGQNPDETDETTELNS 1178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549
		FG-GAP	350..388	CDD:280083	12/38 (32%)
		Int_alpha	409..459	CDD:214549	25/51 (49%)
		Int_alpha	473..>515	CDD:214549	12/44 (27%)
		Integrin_alpha2	507..829	CDD:285619	83/355 (23%)
Itga2	XP_345157.5	Int_alpha	44..92	CDD:214549
		vWA_integrins_alpha_subunit	170..350	CDD:238746	4/20 (20%)
		Int_alpha	430..473	CDD:214549	13/47 (28%)
		Int_alpha	484..535	CDD:214549	18/50 (36%)
		Int_alpha	548..601	CDD:214549	25/52 (48%)
		Int_alpha	611..>637	CDD:214549	8/25 (32%)
		Integrin_alpha2	646..1057	CDD:285619	101/512 (20%)
		Integrin_alpha	1152..1166	CDD:278771	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335708
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940