DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and Itgax

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_067309.1	Gene:	Itgax / 16411	MGIID:	96609	Length:	1169	Species:	Mus musculus

Alignment Length:	1356	Identity:	273/1356 - (20%)
Similarity:	452/1356 - (33%)	Gaps:	485/1356 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQTS-IIVGAPRAQSTL 75
            ||.||..:|.: .||        :::.|...||::   .:.||::::...:| ::||||:
Mouse     8 FLLLLGFVSCL-GFN--------LDAEKLTHFHMD---GAEFGHSVLQYDSSWVVVGAPK----- 55

  Fly    76 ESQRTINETGAIYRCSLTNGVCSP----------------------------------------- 99
            |.:.| |:.|.:|:|....|.|.|
Mouse    56 EIKAT-NQIGGLYKCGYHTGNCEPISLQVPPEAVNISLGLSLAAATNPSWLLACGPTVHHTCREN 119

  Fly   100 -----------------------------------YVLDSRGNVDA------------------- 110
                                               :::|..|::.:
Mouse   120 IYLTGLCFLLSSSFKQSQNFPTAQQECPKQDQDIVFLIDGSGSISSTDFEKMLDFVKAVMSQLQR 184

  Fly   111 --------PYSEY--------TFDSERKDFQWLGG-----------------------SMDGGTK 136
                    .:|:|        .|.|.......||.                       :..|..:
Mouse   185 PSTRFSLMQFSDYFRVHFTFNNFISTSSPLSLLGSVRQLRGYTYTASAIKHVITELFTTQSGARQ 249

  Fly   137 DTDKLLV--------------------------------CAPRFYAPSSRDNHLHGVCYWVNNTV 169
            |..|:|:                                ....||...|:..         ...:
Mouse   250 DATKVLIVITDGRKQGDNLSYDSVIPMAEAASIIRYAIGVGKAFYNEHSKQE---------LKAI 305

  Fly   170 ASTPQH-----VTRISPLRLKSEQVKEE-------DNGNKASFFYIMGELGLSAHVADDNTKFLI 222
            ||.|.|     |.....|:....|:||:       :..:.::|...|.:.|.||....|..  ::
Mouse   306 ASMPSHEYVFSVENFDALKDIENQLKEKIFAIEGTETPSSSTFELEMSQEGFSAVFTPDGP--VL 368

  Fly   223 GAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQE 287
            ||.|..:|.|...||         .::.|.|...:.:...|:
Mouse   369 GAVGSFSWSGGAFLY---------PSNMRPTFINMSQENEDM----------------------- 401

  Fly   288 EDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGY 352
            .|:|.||:.:..|:...:.    .:..||: ::.:|:..||....:........||.|.|.|||.
Mouse   402 RDAYLGYSTALAFWKGVHS----LILGAPR-HQHTGKVVIFTQESRHWRPKSEVRGTQIGSYFGA 461

  Fly   353 SVLAEDLNGDGKTDVIVSAPQHALEDSHDNGAIYVFINKGFFNFERQILRSPV------------ 405
            |:.:.|::.||.||:::....|..|  |..|.              |:...|:
Mouse   462 SLCSVDMDRDGSTDLVLIGVPHYYE--HTRGG--------------QVSVCPMPGVGSRWHCGTT 510

  Fly   406 ------ETMARFGTALSRLGDINHDGYNDVAVGAP--FAGNGTVFIYLG-SENGLRDQPSQRLDA 461
                  ....|||.||:.|||:|.|...|||:|||  ....|.|:|:.| |...:...||||:.|
Mouse   511 LHGEQGHPWGRFGAALTVLGDVNGDSLADVAIGAPGEEENRGAVYIFHGASRQDIAPSPSQRISA 575

  Fly   462 PSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIK- 525
             ||.||:.  ..||..||.|.|:..:|..|.|:|:..  .|.|.|..|:::|..||.....||.
Mouse   576 -SQIPSRI--QYFGQSLSGGQDLTRDGLVDLAVGSKG--RVLLLRTRPILRVSPTVHFTPAEISR 635

  Fly   526 ----------PEQEKVKITACYRLSTTSTDKLVQ-EQELAIRIAMD--KQLKRVKFTQTQTNEIS 577
                      |||.....|.|..:..:...:|.. ...:...:|:|  :...|..|.:|:|..::
Mouse   636 SVFECQEQVAPEQTLSDATVCLHIHESPKTQLGDLRSTVTFDLALDHGRLSTRAIFKETKTRALT 700

  Fly   578 FKVNANFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDS--EEFCETCAIVDPTEPKVST 640
            ........:.|...:..:....:|..|||.|.:::.|. .||.|  :......|:.|.|   ..|
Mouse   701 RVKTLGLNKHCESVKLLLPACVEDSVTPITLRLNFSLV-GVPISSLQNLQPMLAVDDQT---YFT 761

  Fly   641 QNIIFSTGCATD-VCTADLQL--RSKDVSPTYILGSADTLRLNYEITNIGETAYLPQFNVTSTSR 702
            .::.|...|..| :|..||.:  ...|:. |.::||...|.::..::|.||.:|.....:.....
Mouse   762 ASLPFEKNCGADHICQDDLSVVFGFPDLK-TLVVGSDLELNVDVTVSNDGEDSYGTTVTLFYPVG 825

  Fly   703 LAFAQV-PGNC---KVVDAV----------MVCDLNRGRP--------------LAKGDTDSVTI 739
            |:|.:| .|..   |..|..          ::||....|.              ...|...:..:
Mouse   826 LSFRRVAEGQVFLRKKEDQQWQRRGQHSLHLMCDSTPDRSQGLWSTSCSSRHVIFRGGSQMTFLV 890

  Fly   740 SFDVSQLS--GQSLIIHAEVFSTGYEQN----PTDNRQ----------TNVIGLKEFTE-IDASG 787
            :||||..:  |..|::.|.|   |.|.|    |....|          |.:....:||: ::.|.
Mouse   891 TFDVSPKAELGDRLLLRARV---GSENNVPGTPKTTFQLELPVKYAVYTMISSHDQFTKYLNFST 952

  Fly   788 GQTNSQIDLEHYSNSAEIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQ 852
            .:......:||         .:::.:.|...: .::::|::||                 .||.:
Mouse   953 SEKEKTSVVEH---------RFQVNNLGQRDV-PVSINFWVPI-----------------ELKGE 990

  Fly   853 ASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERTVITQ---NR---QSYDIHTSGHVHQTM 911
            |.:              |::|..|            :..:||   ||   ..:|:.|  |: |..
Mouse   991 AVW--------------TVMVSHP------------QNPLTQCYRNRLKPTQFDLLT--HM-QKS 1026

  Fly   912 EVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDFKGKLP---VNRTIVFNCRD 973
            .|||.|:   |.....|.|:.:|....|.|..:             ||.|.   :::|:
Mouse  1027 PVLDCSI---ADCLHLRCDIPSLGILDELYFIL-------------KGNLSFGWISQTL------ 1069

  Fly   974 PEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFS 1038
                     :.:|....|..|..|......|....|.|
Mouse  1070 ---------QKKVLLLSEAEITFNTSVYSQLPGQEAFL--------------------------- 1098

  Fly  1039 INRRIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDELD 1094
               |.:...:.:..:...|:.:|:.|.:||||||:.|:.:|||.|||.|..|:.|:
Mouse  1099 ---RAQTKTVLEMYKVHNPVPLIVGSSVGGLLLLAIITAILYKAGFFKRQYKEMLE 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	16/128 (13%)
		FG-GAP	350..388	CDD:280083	12/37 (32%)
		Int_alpha	409..459	CDD:214549	24/52 (46%)
		Int_alpha	473..>515	CDD:214549	15/41 (37%)
		Integrin_alpha2	507..829	CDD:285619	78/385 (20%)
Itgax	NP_067309.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	23..78		18/63 (29%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	79..138		0/58 (0%)
		vWA_integrins_alpha_subunit	151..326	CDD:238746	21/183 (11%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	341..392		15/61 (25%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	393..444		11/78 (14%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	445..505		19/75 (25%)
		Int_alpha	455..505	CDD:214549	16/65 (25%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	508..566		21/57 (37%)
		Int_alpha	518..573	CDD:214549	24/54 (44%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	571..631		24/64 (38%)
		Integrin_alpha2	616..987	CDD:285619	80/405 (20%)
		Integrin_alpha	1138..1152	CDD:278771	7/14 (50%)
		GFFKR motif	1140..1144		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832083
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840