DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and Itgav

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_032428.2	Gene:	Itgav / 16410	MGIID:	96608	Length:	1044	Species:	Mus musculus

Alignment Length:	1197	Identity:	300/1197 - (25%)
Similarity:	488/1197 - (40%)	Gaps:	261/1197 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MFPHIFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQTS------II 65
            :.|.:.|.|      .:|||.      .:.||....    ....||||:.:...:.|      ::
Mouse    19 LLPGLLLPL------ADAFNL------DVESPAEYA----GPEGSYFGFAVDFFEPSTSSRMFLL 67

  Fly    66 VGAPRAQSTLESQRTINETGAIYRCSLTNG-VCSPYVLDSRGNVDAPYSEYTFDS--ERKDFQWL 127
            ||||:|.:|   |..|.|.|.:.:|..::. .|.|...||.||.|     |..|.  |.|..||.
Mouse    68 VGAPKANTT---QPGIVEGGQVLKCECSSSRRCQPIEFDSTGNRD-----YAKDDPLEFKSHQWF 124

  Fly   128 GGSMDGGTKDTDKLLVCAPRFY--APSSRDNHLHGVCYWVNNTVASTPQHVTRISPLRLKSEQVK 190
            |.|:   ....||:|.|||.::  ....::....|.|:..:.|      .....:|.|  |:.:.
Mouse   125 GASV---RSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGT------KTVEYAPCR--SKNID 178

  Fly   191 EEDNGNKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSK 255
            .:..|      :..|...:....||   :.|:|.||...|:|.:|                  |.
Mouse   179 ADGQG------FCQGGFSIDFTKAD---RVLLGGPGSFYWQGQLI------------------SD 216

  Fly   256 ALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANK 320
            .:.......|.|.|:.: |..::.|.......:|||.||:|:.|.|:......  :|:..|:|.:
Mouse   217 QVAEIISKYDPNVYSIK-YNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIED--FVSGVPRAAR 278

  Fly   321 QSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDS----HD 381
            ..|..||:|  ||::...|.|.|||...|||:||.|.|:|||...||.:.||......|    .:
Mouse   279 TLGMVYIYD--GKNMSSLHNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQE 341

  Fly   382 NGAIYVFINKGFFNFERQILRSPVETMARFGTALSRLGDINHDGYNDVAVGAPFAG---NGTVFI 443
            .|.:.|.:.:...:|:...|.. .|..||||:|::.|||::.||:||:|:.||:.|   .|.|:|
Mouse   342 VGQVSVSLQRAVGDFQTTKLNG-FEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGLVYI 405

  Fly   444 YLGSENGLRDQPSQRLD----APSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYL 504
            :.|...||...|||.|:    |.|..||      ||:.:...:|:|.||:.|..:||...:...|
Mouse   406 FNGRSTGLNSVPSQILEGQWAAQSMPPS------FGYSMKGATDVDRNGYPDLVVGAFGVDRAVL 464

  Fly   505 YRAYPVVKVHA------TVKSESREIKPEQEKVKITACYR----LSTTSTDKLVQEQELAIRIAM 559
            |||.|||.|:|      ::.::..:|.|........:|:.    |.......|.::....:.:.:
Mouse   465 YRARPVVTVNAGLEVYPSILNQDNKICPLPGTALKVSCFNVRFCLKADGKGTLPRKLHFQVELLL 529

  Fly   560 DK-----QLKRVKFTQTQTNEISFKVNANF--GE-QCRDFETQVR-YSE-KDIFTPIDLEMHYEL 614
            ||     .::|..|...: :.:..|....|  |: ||.:....:| .|| :|..|||.:.|.|.|
Mouse   530 DKLKQKGAIRRALFLHNR-SPVHSKTMTVFRGGQMQCEELVAYLRDESEFRDKLTPITIFMEYRL 593

  Fly   615 TKKV--------PDSEEFCETCAIVDPTEPKVSTQ-NIIFSTGCATDVCTADLQLR-SKDVSPTY 669
            .::.        |...:|         |...||.| :|:...| ..:||...|::. :.|....|
Mouse   594 DQRTAADATGLQPILNQF---------TPANVSRQAHILLDCG-EDNVCKPKLEVSVNSDQKKIY 648

  Fly   670 ILGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAFAQVPGNCKVVDAV------------MVCD 722
            | |..:.|.|..:..|.||.||..:..|:...:..|..|..|.:.:..:            :|||
Mouse   649 I-GDDNPLTLTVKAQNQGEGAYEAELIVSIPPQADFIGVVRNNEALARLSCAFKTENQTRQVVCD 712

  Fly   723 LNRGRPLAKGDTDSVTISFDVSQLS--GQSLIIHAEVFSTGYEQNPTDNRQTNV---IGLKEFTE 782
            |  |.|:..|......:.|.|.|.|  ..|:....::.|:    |..||....|   :.|.....
Mouse   713 L--GNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLKIQSS----NSFDNVSPVVSYKVDLAVLAA 771

  Fly   783 IDASGGQTNSQIDLE----HYSNSAE-------IVNN-YEIKSNGPSVIEQLTVSFYIPIAYKVA 835
            ::..|..:...|.|.    .|..:.|       ||.: ||:::||||...:..::...|  ||..
Mouse   772 VEIRGVSSPDHIFLPIPNWEYKENPETEEDVGPIVQHIYELRNNGPSSFSKAILNLQWP--YKYN 834

  Fly   836 GSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERTVITQNR---- 896
            .:|.:..:.......|..:.|:::         |.:.:..|.:..|..:|..||..:...|
Mouse   835 NNTLLYILHYDIDGPMNCTADTEI---------NPLRIKTPEKNDTAAAGQGERNHLITKRDLTL 890

  Fly   897 QSYDIHTSG-HVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDFKGK 960
            :..|:||.| .:.:.:::       |..:.|..|...|          |..||:. |.::.|..|
Mouse   891 REGDVHTLGCGIAKCLQI-------TCQVGRLDRGKSA----------ILYVKSL-LWTETFMNK 937

  Fly   961 LPVNRTIVFNCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLK 1025
                                             .|.|..||:..:....|:..|::      :|.
Mouse   938 ---------------------------------ENQNHSYSLKSSASFNIIEFPYK------NLP 963

  Fly  1026 LQKKGDPTSTSFSINRRIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTK- 1089
            ::...:.|..:.:|...|:|      ....:|:|:||::|:.|||||:.:.:::|:.|||.|.:
Mouse   964 IEDLFNSTLVTTNITWGIQP------APMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRP 1022

  Fly  1090 -KDELDRLVQQNPVEPEAENLNSGGNN 1115
             ::|.:| .|..|.|      |..||:
Mouse  1023 PQEEQER-EQLQPHE------NGEGNS 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	18/58 (31%)
		FG-GAP	350..388	CDD:280083	15/41 (37%)
		Int_alpha	409..459	CDD:214549	25/52 (48%)
		Int_alpha	473..>515	CDD:214549	17/41 (41%)
		Integrin_alpha2	507..829	CDD:285619	87/380 (23%)
Itgav	NP_032428.2	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	32..98		19/78 (24%)
		Int_alpha	46..103	CDD:214549	18/59 (31%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	109..170		18/74 (24%)
		WD40 repeat	126..183	CDD:293791	13/67 (19%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	173..225		14/80 (18%)
		WD40 repeat	188..248	CDD:293791	15/81 (19%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	237..291		18/57 (32%)
		Int_alpha	248..>288	CDD:214549	15/43 (35%)
		WD40 repeat	254..298	CDD:293791	14/47 (30%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	292..357		22/64 (34%)
		Int_alpha	302..355	CDD:214549	17/52 (33%)
		WD40 repeat	307..362	CDD:293791	16/54 (30%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	358..415		24/57 (42%)
		Int_alpha	367..421	CDD:214549	25/53 (47%)
		WD40 repeat	371..422	CDD:293791	22/50 (44%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	419..482		24/68 (35%)
		Int_alpha	434..476	CDD:214549	17/41 (41%)
		Integrin_alpha2	467..910	CDD:285619	104/478 (22%)
		GFFKR motif	1015..1019		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1023..1044		8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832016
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740