Protein Alignment scb and Itgae

DIOPT Version :10

• Sequence 1: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Sequence 2: NP_032425.2
• Gene: Itgae / 16407
• MGIID: 1298377
• Length: 1167
• Species: Mus musculus
• Alignment Length: 1029
• Identity: 238/1029 - (23%)
• Similarity: 393/1029 - (38%)
• Gaps: 299/1029 - (29%)

  Fly   166 NNT------VASTPQH-----VTRISPL-----RLKSEQVKEEDNGNKASFFYIMGELGLSAHVA 214
            |||      :||.|:.     ||..|.|     :|:...|..|.....| ..|.:.:.|.||.:.
Mouse   341 NNTYRELKLIASDPKEAHTFKVTNYSALDGLLSKLQQHIVHMEGTVGDA-LQYQLAQTGFSAQIL 404

  Fly   215 DDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIP 279
            |.. :.|:|..|...|.|..:||          :::......|.:|.:: ||.  |.::
Mouse   405 DKG-QVLLGTVGAFNWSGGALLY----------STQNGRGCFLNQTAKE-DSR--TVQY------ 449

  Fly   280 TPGLWGQEEDSYFGYAV-----SSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKYH 339
                      ||.||::     :.|         :.|||.||: :|..|.  :|::| |...:..
Mouse   450 ----------SYLGYSLAVLHKAHG---------VSYVAGAPR-HKLRGA--VFELR-KEDREED 491

  Fly   340 VF----RGEQFGEYFGYSVLAEDLNGDGKTD-VIVSAPQHALEDSHDNGAIYVF---INKGFFNF 396
            .|    .|||.|.|||..:...|::.||.|| ::|:||.:.:..  :.|.:||:   .....|:.
Mouse   492 AFVRRIEGEQMGSYFGSVLCPVDIDMDGTTDFLLVAAPFYHIRG--EEGRVYVYQVPEQDASFSL 554

  Fly   397 ERQILRSPVETMARFGTALSRLGDINHDGYNDVAVGAPFAG--------NGTVFIYLGSENGLRD 453
            ...:...|..|.:|||.|::.:||||.|.:.|||:|||..|        .|:|:||.|...||.|
Mouse   555 AHTLSGHPGLTNSRFGFAMAAVGDINQDKFTDVAIGAPLEGFGAGDGASYGSVYIYNGHSGGLYD 619

  Fly   454 QPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVK 518
            .|||::.|.|...   |.|.||..:|.|.|.:|:|..|..:|:.::..|  .|:.|||.:  ||
Mouse   620 SPSQQIRASSVAS---GLHYFGMSVSGGLDFNGDGLADITVGSRDSAVV--LRSRPVVDL--TV- 676

  Fly   519 SESREIKPEQ------EKVKITACYRLSTTSTDKLVQEQELAIRIAMD----KQLKRVKFTQTQT 573
              |....|:.      .|:.:..|:.:.::........:|:.:...:|    ||.:|::...:..
Mouse   677 --SMTFTPDALPMVFIGKMDVKLCFEVDSSGVASEPGLREMFLNFTVDVDVTKQRQRLQCEDSSG 739

  Fly   574 NEISFKVNANFGEQCRDF---ETQVRYSEKDIFTPIDLEMHYELTKK-------VPDSEEFCETC 628
            .:...:........|..|   .|: ...|:|.|:.|.:::.||....       .|..:.:.|..
Mouse   740 CQSCLRKWNGGSFLCEHFWLISTE-ELCEEDCFSNITIKVTYEFQTSGGRRDYPNPTLDHYKEPS 803

  Fly   629 AIVD-PTEPKVSTQNIIFSTGCATDVCTADLQLRSKDVSPTYILGSADTLRLNYEITNIGETAYL 692
            ||.. |.|.  ..:|.:|        |.|::||.:.......::|....:.:|..:||.||.:|:
Mouse   804 AIFQLPYEK--DCKNKVF--------CIAEIQLTTNISQQELVVGVTKEVTMNISLTNSGEDSYM 858

  Fly   693 PQFNVTSTSRLAFAQVPG------NC---KVVDAVMVCDLNRGRPLAKGDTDSVTISFDVSQLSG 748
            ....:.....|.|.::..      .|   |.|.:|:|.:...|.|:.|..:.:|::::.:
Mouse   859 TNMALNYPRNLQFKKIQKPVSPDVQCDDPKPVASVLVMNCKIGHPILKRSSVNVSVTWQL----- 918

  Fly   749 QSLIIHAEVFSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNSAEIVNNYEIKS 813
                          |::...||..::       .:..|.....|   |...:.|.:..:.:....
Mouse   919 --------------EESVFPNRTADI-------TVTISNSNEKS---LARETRSLQFRHAFIAVL 959

  Fly   814 NGPSVIEQLT---VSFYIPIAYKVAGST---AIIPIINVTSLKMQASYDSQLLSIDLYDQNNTML 872
            :.|||:...|   .|.:....:.|.|..   |:..:.....:|:|   |.|::.:
Mouse   960 SRPSVMYMNTSQSPSDHKEFFFNVHGENLFGAVFQLQICVPIKLQ---DFQIVRV---------- 1011

  Fly   873 VVDPVEVTTTLSGGLERTVITQNRQSYDIHTSG-----HVHQTMEVLDTSMVATASMSRKRRDLK 932
                    ..|:...:.|..||:::.    ..|     ||.:...|                 :.
Mouse  1012 --------KNLTKTQDHTECTQSQEP----ACGSDPVQHVKEWHSV-----------------VC 1047

  Fly   933 ALTANREQY---ARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFRPEKSI 994
            |:|:|:|..   |.||......||.|  ..:||:...|.||                     ||:
Mouse  1048 AITSNKENVTVAAEISVGHTKQLLRD--VSELPILGEISFN---------------------KSL 1089

  Fly   995 --NLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPNII-SKHQET-G 1055
              .||..                                        |.|.:..:| .|.:|| .
Mouse  1090 YEGLNAE----------------------------------------NHRTKITVIFLKEEETRS 1114

  Fly  1056 LPIWIIIVSVIGGLLLLSAISYLLYKFGFFNR---------TKKDEL--DRLVQ 1098
            ||  :||.|.|||||:|..|..:|:|.|||.|         |::.:|  |.|:|
Mouse  1115 LP--LIIGSSIGGLLVLVVIIAILFKCGFFKRKYQQLNLESTRRAQLKADSLLQ 1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549
		FG-GAP	350..388	CDD:460357	12/38 (32%)
		Int_alpha	409..459	CDD:214549	27/57 (47%)
		Int_alpha	473..>515	CDD:214549	14/41 (34%)
		Integrin_alpha2	509..829	CDD:462478	65/352 (18%)
Itgae	NP_032425.2	FG-GAP 1	27..81
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	84..142
		X-domain (extra domain)	149..192
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..191
		vWA_integrins_alpha_subunit	196..371	CDD:238746	10/29 (34%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	383..435		14/63 (22%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	438..491		19/84 (23%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	492..552		19/61 (31%)
		Int_alpha	502..558	CDD:214549	16/57 (28%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	555..619		25/63 (40%)
		Int_alpha	566..625	CDD:214549	27/58 (47%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	623..683		22/69 (32%)
		Int_alpha	636..>659	CDD:214549	8/22 (36%)
		Integrin_alpha2	669..>939	CDD:462478	57/311 (18%)
		GFFKR motif	1140..1144		3/3 (100%)