DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and Itga7

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	XP_030100775.1	Gene:	Itga7 / 16404	MGIID:	102700	Length:	1180	Species:	Mus musculus

Alignment Length:	1265	Identity:	291/1265 - (23%)
Similarity:	485/1265 - (38%)	Gaps:	343/1265 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PHIFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIR-------QTSIIV 66
            |.|:..:.:|::.:    |:| |:...|..............|.||:::.:.       |:.::|
Mouse    13 PGIYYLITSLLAGL----FLP-PAIAFNLDVMGAIRKEGEPGSLFGFSVALHRQLQPRPQSWLLV 72

  Fly    67 GAPRAQSTLESQRTINETGAIYRC--SLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLGG 129
            |||:|.: |..|:. |.||.::.|  ||....|....:|...||         ..|.|:.||||.
Mouse    73 GAPQALA-LPGQQA-NRTGGLFACPLSLEETDCYRVDIDRGANV---------QKESKENQWLGV 126

  Fly   130 SM----DGGTKDTDKLLVCAPRFYAPSSRDNHLH-----GVCYWVNNTVASTPQHVTRISPLRLK 185
            |:    .||     |::.||.|:.:....|..|.     |.|:.::..:|
Mouse   127 SVRSQGPGG-----KIVTCAHRYESRQRVDQALETRDVIGRCFVLSQDLA--------------- 171

  Fly   186 SEQVKEEDNGNKASFF---------YIMGELGLSAHVADDNTKFLIGAPGINTWRGS--VILYRQ 239
               :::|.:|.:..|.         :...:.|.:|..:.|:...:.||||...|:|:  |.|..|
Mouse   172 ---IRDELDGGEWKFCEGRPQGHEQFGFCQQGTAATFSPDSHYLVFGAPGTYNWKGTARVELCAQ 233

  Fly   240 VDP-----VDNPTASRRDTSKALR------RTY------RDVDSNDYTPEHYAPEIPTPGLWGQE 287
            ..|     .|.|..:..:..:..|      .:|      .::||:|.....|....|...|.|..
Mouse   234 GSPDLAHLDDGPYEAGGEKEQDPRLIPVPANSYLGLLFVTNIDSSDPDQLVYKTLDPADRLTGPA 298

  Fly   288 ED----SYFGYAVSSGFFDSSNPTKLLYVATAPQAN---------KQSGEAYIFDVRGKSIHKYH 339
            .|    ||.|:::.|| .......:|.:||.||:||         |.|....|.:|
Mouse   299 GDLTLNSYLGFSIDSG-KGLMRSEELSFVAGAPRANHKGAVVILRKDSASRLIPEV--------- 353

  Fly   340 VFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDNGAIYVFINKGFFNFERQILRSP 404
            |..||:....||||:...|||.||..|:||.||..........||:||::|:|....:...||..
Mouse   354 VLSGERLTSGFGYSLAVTDLNNDGWADLIVGAPYFFERQEELGGAVYVYMNQGGHWADISPLRIC 418

  Fly   405 VETMARFGTALSRLGDINHDGYNDVAVGAPFAGNGTVFIYLGSENGLRDQPSQRLDAPSQQPSKY 469
            ....:.||.:|:.|||:|.||:.|:||||||.|:|.||||.||..|:..:|||.|:..:     .
Mouse   419 GSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSSLGVVVKPSQVLEGEA-----V 478

  Fly   470 GSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEK---- 530
            |...||:.||.|.|:|||.:.|..:|: .|:...|:||.||:.|...:..:.|.|..||..
Mouse   479 GIKSFGYSLSGGLDVDGNHYPDLLVGS-LADTAALFRARPVLHVSQEIFIDPRAIDLEQPNCADG 542

  Fly   531 ----VKITACYRLSTTSTDKLVQEQELAIRIAMD--------KQLKRVKFTQTQTNEISFK---- 579
                |.|..|:......:.   ....:|:...:|        .|:.||.|.....:::..:
Mouse   543 RLVCVDIKICFSYVAVPSS---YSPSVALDYMLDGDTDRRLRGQVPRVTFLSRGLDDLRHQSSGT 604

  Fly   580 --VNANFGEQCRDFETQVRYSEKDIFTPIDLEMHY-----ELTKKVPDSEEFCETCAIVDPTEPK 637
              :.......|.|...|::.:.||....|.:.:.|     .|.::.| .:|......|::..:|.
Mouse   605 VWLKHQHDRVCGDTVFQLQENVKDKLRAIVVTLSYGLRTPPLGRQAP-GQELPTVAPILNAHQPS 668

  Fly   638 VSTQNIIF-STGCATD-VCTADLQL-------RSKDV------------SPTYILGSADTLRLNY 681
            .....|.| ..||..| :|.::|||       |..|.            :..:.|.....:.|..
Mouse   669 TQRTEIHFLKQGCGEDKICQSNLQLERYQFCSRISDTEFQALPMDLDGRTALFALSGQPFIGLEL 733

  Fly   682 EITNI----------GETAYLPQFNVTSTSRLAFAQVPGNCKVVDAV-------------MVCDL 723
            .:||:          |:.|:..|..||..:.|.::.|    :.:|:|             :.|:|
Mouse   734 TVTNLPSDPARPQADGDDAHEAQLLVTLPASLRYSGV----RALDSVEKPLCLSNDSASHVECEL 794

  Fly   724 NRGRPLAKG---------DTDSVTISFDVSQLSGQSLIIHAEVFSTGYEQNPTDNRQTNVIGLKE 779
              |.|:.:|         .|..:||  :.::|..:.|:
Mouse   795 --GNPMKRGAQVTFYLILSTSGITI--ETTELEVKLLL--------------------------- 828

  Fly   780 FTEIDASGGQTNSQIDLEHYSNSAEIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPII 844
                     .|.|:.:|:..|..|.:.....:..:|.:..:||..|      .:|.|.:|:....
Mouse   829 ---------ATISEQELDPVSVRAHVFIELPLSISGVATPQQLFFS------GEVKGESAMRSER 878

  Fly   845 NVTS-LKMQASYDSQLLSIDL-----------YDQNNTMLVVDPVEVTTTLSGG---------LE 888
            :|.| :|.:.:..:|..|::.           ::..|...::.|:.|  .|.||         ..
Mouse   879 DVGSKVKYEVTVSNQGQSLNTLGSAFLNIMWPHEIANGKWLLYPMRV--ELEGGQGPGKRGICSP 941

  Fly   889 RTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDL--------KALTANREQYARIS 945
            |..|.|                   ||..     |..|:||:|        .........:..:|
Mouse   942 RPNILQ-------------------LDVD-----SRDRRRRELGQPEPQEPPEKVEPSTSWWPVS 982

  Fly   946 NVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVRAEMRV-----------HFRPEKSINLNMR 999
            :.:..::..|..:|   ..:.:||:|  |..:....|.:.|           .:...||:.:.:|
Mouse   983 SAEKRNVTLDCAQG---TAKCVVFSC--PLYSFDRAAVLHVWGRLWNSTFLEEYMAVKSLEVIVR 1042

  Fly  1000 YSVDLNE--VNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPNIISKHQETGLPIWIII 1062
            .::.:..  .|.:|.|                   .||...:...::|..:...   |:|.|:|:
Mouse  1043 ANITVKSSIKNLLLRD-------------------ASTVIPVMVYLDPMAVVVE---GVPWWVIL 1085

  Fly  1063 VSVIGGLLLLSAISYLLYKFGFFNRTKKDE 1092
            ::|:.|||:|:.:..||:|.|||.|.|..|
Mouse  1086 LAVLAGLLVLALLVLLLWKLGFFKRAKHPE 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	18/60 (30%)
		FG-GAP	350..388	CDD:280083	17/37 (46%)
		Int_alpha	409..459	CDD:214549	28/49 (57%)
		Int_alpha	473..>515	CDD:214549	18/41 (44%)
		Integrin_alpha2	507..829	CDD:285619	72/401 (18%)
Itga7	XP_030100775.1	Int_alpha	48..109	CDD:214549	18/62 (29%)
		Int_alpha	304..355	CDD:214549	16/60 (27%)
		Int_alpha	362..415	CDD:214549	20/52 (38%)
		Int_alpha	421..473	CDD:214549	28/51 (55%)
		Int_alpha	483..>523	CDD:214549	18/40 (45%)
		Integrin_alpha2	515..1005	CDD:369878	101/572 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832040
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740