DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and Itga6

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_001264899.1	Gene:	Itga6 / 16403	MGIID:	96605	Length:	1091	Species:	Mus musculus

Alignment Length:	1217	Identity:	284/1217 - (23%)
Similarity:	478/1217 - (39%)	Gaps:	312/1217 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 HIFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIR-------QTSIIVG 67
            ::...|||.:.  .|||...|...||..        :....|.||::|.:.       :..::||
Mouse    11 YLSAGLLARLG--TAFNLDTREDNVIRK--------SGDPGSLFGFSLAMHWQLQPEDKRLLLVG 65

  Fly    68 APRAQSTLESQRTINETGAIYRCSLTNGVCSPYVLDSRGNVDAPYSEYTFD------SERKDFQW 126
            ||||:: |..||. |.||.:|.|.:|          |||    |.:...||      ||.|:.||
Mouse    66 APRAEA-LPLQRA-NRTGGLYSCDIT----------SRG----PCTRIEFDNDADPMSESKEDQW 114

  Fly   127 LGGSMD----GGTKDTDKLLVCAPRF-------YAPSSRDNHLHGVCYWVNNTVASTPQHVTRIS 180
            :|.::.    ||     |::.||.|:       ....|||  :.|.||
Mouse   115 MGVTVQSQGPGG-----KVVTCAHRYEKRQHVNTKQESRD--IFGRCY----------------- 155

  Fly   181 PLRLKSEQVKEEDNGNKASFFYIMGEL-----------GLSAHVADDNTKFLIGAPGINTWRGSV 234
               :.|:.::.||:.:...:.:..|.|           |::|....|....:.||||...|:|.|
Mouse   156 ---VLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIV 217

  Fly   235 ILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTP-------EHYAPEIPTPGLWGQEEDSYF 292
                :|:..:|              |:.|::..:..|       :|....:|.|.      :||.
Mouse   218 ----RVEQKNN--------------TFFDMNIFEDGPYEVGGETDHDESLVPVPA------NSYL 258

  Fly   293 GYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIH--KYHVFRGEQFGEYFGYSVL 355
            |:::.||....|. ..:.:|:.||:|| .||...:.....||.|  ..::|.||.....|||.|.
Mouse   259 GFSLDSGKGIVSK-DDITFVSGAPRAN-HSGAVVLLKRDMKSAHLLPEYIFDGEGLASSFGYDVA 321

  Fly   356 AEDLNGDGKTDVIVSAPQHALEDSHDNGAIYVFIN-KGFFNFERQI-LRSPVETMARFGTALSRL 418
            ..|||.||..|:::.|||:...|....||:||:|| :|.::..:.| |....::|  ||.::..:
Mouse   322 VVDLNADGWQDIVIGAPQYFDRDGEVGGAVYVYINQQGKWSNVKPIRLNGTKDSM--FGISVKNI 384

  Fly   419 GDINHDGYNDVAVGAPFAGNGTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSD 483
            ||||.|||.|:|||||:...|.||||.||..|:..:|:|.|:..|.        .||:.::...|
Mouse   385 GDINQDGYPDIAVGAPYDDLGKVFIYHGSPTGIITKPTQVLEGTSP--------YFGYSIAGNMD 441

  Fly   484 IDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEK---------VKITACYR- 538
            :|.|.:.|.|:|: .:::|.::|:.||:.:..|:......|...|:.         :|:.||:.
Mouse   442 LDRNSYPDLAVGS-LSDSVTIFRSRPVINILKTITVTPNRIDLRQKSMCGSPSGICLKVKACFEY 505

  Fly   539 -------------LSTTSTDKLVQEQELAIRIAMDKQLKRVKFTQTQTNEISFKVNANFGEQCRD 590
                         |.....:|..::..|:.|:....|....|:||..|      :|......|.:
Mouse   506 TAKPSGYNPPISILGILEAEKERRKSGLSSRVQFRNQGSEPKYTQELT------LNRQKQRACME 564

  Fly   591 FETQVRYSEKDIFTPIDLEMHYELTKKVPDS----EEFCETCAIVDPTEPK-VSTQNIIFSTGCA 650
            ....::.:.:|...||.:....|:.:  |.|    ....|...|::..|.| |.|.......||.
Mouse   565 ETLWLQENIRDKLRPIPITASVEIQE--PSSRRRVNSLPEVLPILNSNEAKTVQTDVHFLKEGCG 627

  Fly   651 TD-VCTADLQLRSKDVS-----------------PTYILGSADTLRLNYEITNI----------G 687
            .| ||.::|:|..|..:                 |..:|.....:.|...:||.          |
Mouse   628 DDNVCNSNLKLEYKFGTREGNQDKFSYLPIQKGIPELVLKDQKDIALEITVTNSPSDPRNPRKDG 692

  Fly   688 ETAYLPQFNVTSTSRL---------AFAQVPGNCKVVDAVMVCDLNRGRPLAKGDTDSVT----- 738
            :.|:..:...|....|         ||.:...:|.........|...|.|..:  ..|||
Mouse   693 DDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKR--NSSVTFYLIL 755

  Fly   739 ----ISFDVSQLSGQSLIIHAEVFSTGYEQN--PTDNRQTNVIGLKEFTEIDASGGQTNSQIDLE 797
                ::||.:.|.     |:.::.:|..:.|  |...:...||.|.    :..||....||:
Mouse   756 STTEVTFDTTDLD-----INLKLETTSNQDNLAPITAKAKVVIELL----LSVSGVAKPSQV--- 808

  Fly   798 HYSNSAEIVNNYEIKSNGP--SVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLL 860
            ::..:  :|....:||...  |:||           |:........|:.|:.:..:...:..::
Mouse   809 YFGGT--VVGEQAMKSEDEVGSLIE-----------YEFRVINLGKPLKNLGTATLNIQWPKEI- 859

  Fly   861 SIDLYDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMS 925
                 .....:|.:..||     |.|||:.|...:.:                ::...:..:..|
Mouse   860 -----SNGKWLLYLMKVE-----SKGLEQIVCEPHNE----------------INYLKLKESHNS 898

  Fly   926 RKRRDLKALTANREQYARISNVKAHDLLSDDFKGKL-PVNRTIVFNCRDPEMTICVRAEMRVHFR 989
            ||:|:|                 ....:.|..|..| |..:....||......:.:|..:| ...
Mouse   899 RKKREL-----------------PEKQIDDSRKFSLFPERKYQTLNCSVNVRCVNIRCPLR-GLD 945

  Fly   990 PEKSINLNMR---------YSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEP 1045
            .:.|:.|..|         || .||.::.:|....:......::||...|.....:...::.:.
Mouse   946 SKASLVLRSRLWNSTFLEEYS-KLNYLDILLRASIDVTAAAQNIKLPHAGTQVRVTVFPSKTVA- 1008

  Fly  1046 NIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDE 1092
                  |.:|:..|||:::|:.|:|:|:.:.:||:|.|||.|::.|:
Mouse  1009 ------QYSGVAWWIILLAVLAGILMLALLVFLLWKCGFFKRSRYDD 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	19/58 (33%)
		FG-GAP	350..388	CDD:280083	17/37 (46%)
		Int_alpha	409..459	CDD:214549	25/49 (51%)
		Int_alpha	473..>515	CDD:214549	12/41 (29%)
		Integrin_alpha2	507..829	CDD:285619	77/399 (19%)
Itga6	NP_001264899.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	30..95		25/88 (28%)
		Int_alpha	40..100	CDD:214549	23/75 (31%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	101..166		20/91 (22%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	176..229		15/70 (21%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	244..300		18/63 (29%)
		Int_alpha	254..>292	CDD:214549	13/45 (29%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	301..363		24/61 (39%)
		Int_alpha	314..359	CDD:214549	20/44 (45%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	364..419		26/56 (46%)
		Int_alpha	374..425	CDD:214549	26/52 (50%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	420..479		17/67 (25%)
		Int_alpha	431..>454	CDD:214549	7/22 (32%)
		Integrin_alpha2	464..939	CDD:369878	99/553 (18%)
		GFFKR motif	1040..1044		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832086
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740