Protein Alignment scb and Itga3

DIOPT Version :10

• Sequence 1: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Sequence 2: NP_001293091.1
• Gene: Itga3 / 16400
• MGIID: 96602
• Length: 1068
• Species: Mus musculus
• Alignment Length: 1230
• Identity: 284/1230 - (23%)
• Similarity: 477/1230 - (38%)
• Gaps: 330/1230 - (26%)

  Fly    29 PRPSRVINSPKHL--------------KFHIN-QTR----------SSYFGYTLVI-RQTS---- 63
            |.|.||..:|..|              .|..| .||          .|.|||::.: |||.
Mouse     3 PGPCRVPRAPGWLLRALALMVAACGRVAFAFNLDTRFLVVKEAVNPGSLFGYSVALHRQTERQQR 67

  Fly    64 --IIVGAPRAQSTLESQRTINETGAIYRCSLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDF-- 124
              ::.||||..:..:..  .|.|||:|.|.||                    .:..|.||.|.
Mouse    68 YLLLAGAPRDLAVGDDY--TNRTGAVYLCPLT--------------------AHKDDCERMDISE 110

  Fly   125 -----------QWLGGSMDGGTKDTDKLLVCAPRF----YAPSSRDNHLHGVCYWVNNTVASTP- 173
                       .|||.:: .......::||||.|:    ::.......:.|.||...|.:...|
Mouse   111 KSDPDHHIIEDMWLGVTV-ASQGPAGRVLVCAHRYTKVLWSGLEDQRRMVGKCYVRGNDLQLDPG 174

  Fly   174 -----QHVTRISPLRLKSEQVKEEDNGNKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGS 233
                 .|              .|..|.|.......|.:||.|.....:...|  ||||...|:|:
Mouse   175 DDWQTYH--------------NEMCNSNTDYLQTGMCQLGTSGGFTQNTVYF--GAPGAYNWKGN 223

  Fly   234 VILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDS--YFGYAV 296
            ..:.::                      :|.|.::|:..            |.||..  |.||.|
Mouse   224 SYMIQR----------------------KDWDLSEYSYR------------GSEEQGNLYIGYTV 254

  Fly   297 SSGFFDSSN----PTKLLYVATAPQANKQSGEAYIF-DVRGKSIHKYHVFRGEQFGEYFGYSVLA 356
            ..|     |    ||.::.|.|....::..|..::. ...|..:.:..|.:|.|.|.|||.::..
Mouse   255 QVG-----NAILHPTDIITVVTGAPRHQHMGAVFLLKQESGGDLQRKQVLKGTQVGAYFGSAIAL 314

  Fly   357 EDLNGDGKTDVIVSAPQHALEDSHDNGAIYVFINKGFFNFERQ---ILRSPVETMARFGTALSRL 418
            .|||.||..|::|.||.:........||:|||:|:...:|..|   :|..|  :.:.||.:::.:
Mouse   315 ADLNNDGWQDLLVGAPYYFERKEEVGGAVYVFMNQAGASFPDQPSLLLHGP--SRSAFGISIASI 377

  Fly   419 GDINHDGYNDVAVGAPFAGNGTVFIYLGSENGLRDQPSQ-----RLDAPSQQPSKYGSHMFGHGL 478
            ||||.||:.|:||||||.|.|.|:||..|..||..||.|     :|..|       |...||:.|
Mouse   378 GDINQDGFQDIAVGAPFEGLGKVYIYHSSSGGLLRQPQQIIHGEKLGLP-------GLATFGYSL 435

  Fly   479 SRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKV-HATVKSESREIKP----EQEKVKITACYR 538
            |...|:|.|.:.|..:|: .::.:.|.||.||:.: |.|:.:....:.|    ....|::..|:.
Mouse   436 SGKMDVDENLYPDLLVGS-LSDHIVLLRARPVINILHRTLVARPAVLDPALCTATSCVQVELCFA 499

  Fly   539 LSTTSTDKLVQEQ-ELAIRIAMDKQLK--RVKFTQTQTNEIS--FKVNANFGEQCRDFETQVRYS 598
            .:.::.:...:.. .||..:..|:..:  |::|.::|::...  |.:...   .|:..|..:..:
Mouse   500 YNQSAGNPNYRRNITLAYTLEADRDRRPPRLRFARSQSSVFHGFFSMPET---HCQTLELLLMDN 561

  Fly   599 EKDIFTPIDLEMHYELTKKVPDSEEF----CETCAIVDPTEPKVSTQNIIFSTGCATD-VCTADL 658
            .:|...||.:.|:|.|..::||..:.    .:...:::..:...:...:.|...|..| .|.::|
Mouse   562 VRDKLRPIVIAMNYSLPLRMPDRLKLGLRSLDAYPVLNQAQAMENHTEVHFQKECGPDNKCDSNL 626

  Fly   659 QLR----SKDVSP-TYILGSADT--LRLNYEITN------IGETAY--LPQFNVTSTSRLAFAQV 708
            |:|    |:.:.| :.:..|.||  |.|:..:||      .||.|:  |....|.|...|:..:.
Mouse   627 QMRAAFLSEQLQPLSRLQYSRDTKKLFLSINVTNSPSSQRAGEDAHEALLTLEVPSALLLSSVRP 691

  Fly   709 PGNCKVVDAVMVCDLNRGRPLAKGDTDSVTISFDV--SQLSGQSLIIHAEVFSTGYEQNPTDNRQ 771
            .|.|:..:..::|:|  |.|..:.....:.|:|:|  ..|..:.|.:..::.::.::    ||.|
Mouse   692 SGTCQANNETILCEL--GNPFKRNQRMELLIAFEVIGVTLHTRDLPVLLQLSTSSHQ----DNLQ 750

  Fly   772 TNVIGLKEFTEIDASGGQTNSQIDLEHYSNSAEIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAG 836
            ..::.|               |:|   |:..|.:           |::.....||:   ...|.|
Mouse   751 PVLLTL---------------QVD---YTLQASL-----------SLMNHRLQSFF---GGTVMG 783

  Fly   837 STAIIPIINVTS-LKMQ----------ASYDSQLLSIDL-YDQNNTMLVVDPVEVTTTLSGGLER 889
            ..|:....:|.| ||.:          |:..:.:|.::. |:..|...::.|.|:|...:|
Mouse   784 EAAMKTAEDVGSPLKYEFQVSPVGDGLAALGTLVLGLEWPYEVTNGKWLLYPTEITIHSNG---- 844

  Fly   890 TVITQNRQSYDIHTSGHVHQTMEV-LDTSMVATASMSRKRRDL--------------KALTANRE 939
                    |:....||::...:.: |....|...|..|:||.|              .|..|..|
Mouse   845 --------SWPCQPSGNLVNPLNLTLSDPGVTPLSPQRRRRQLDPGGDQSSPPVTLAAAKKAKSE 901

  Fly   940 QYARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMT----ICVRAEMRVHFRPEKSINLNMRY 1000
            .....||.:|               |.:...|..|:.:    :.|:|.:           .|..:
Mouse   902 TVLTCSNGRA---------------RCVWLECPLPDTSNITNVTVKARV-----------WNSTF 940

  Fly  1001 SVDLNEVNAILVDPWEYFVILTDLKLQKKGDPT------STSFSINRRIEPNIISKHQETGLP-- 1057
            ..|..:.:.:.||.|....:.|.:       ||      :|.||::  |:..::.:     ||
Mouse   941 IEDYKDFDRVRVDGWATLFLRTSI-------PTINMENKTTWFSVD--IDSELVEE-----LPAE 991

  Fly  1058 --IWIIIVSVIGGLLLLSAISYLLYKFGFFNRTK------KDELDRLVQQNPVEPEAENL 1109
              :|:::|:|..|||||..|..||:|..||..|:      |....|:.:::...|....|
Mouse   992 IELWLVLVAVGAGLLLLGLIILLLWKCDFFKPTRYYRIMPKYHAVRIREEDRYPPPGSTL 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	19/58 (33%)
		FG-GAP	350..388	CDD:460357	14/37 (38%)
		Int_alpha	409..459	CDD:214549	26/54 (48%)
		Int_alpha	473..>515	CDD:214549	14/42 (33%)
		Integrin_alpha2	509..829	CDD:462478	69/351 (20%)
Itga3	NP_001293091.1	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	38..103		20/86 (23%)
		Int_alpha	48..108	CDD:214549	22/81 (27%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	110..171		12/61 (20%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	185..235		15/73 (21%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	236..293		16/73 (22%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	294..355		22/60 (37%)
		Int_alpha	305..353	CDD:214549	19/47 (40%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	357..412		26/56 (46%)
		Int_alpha	368..418	CDD:214549	26/49 (53%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	416..478		20/69 (29%)
		Integrin_alpha2	464..918	CDD:462478	101/521 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..890		6/24 (25%)