DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment scb and Itga2b

DIOPT Version :9

Sequence 1:NP_523750.2 Gene:scb / 36692 FlyBaseID:FBgn0286785 Length:1115 Species:Drosophila melanogaster
Sequence 2:NP_034705.2 Gene:Itga2b / 16399 MGIID:96601 Length:1033 Species:Mus musculus


Alignment Length:1162 Identity:298/1162 - (25%)
Similarity:456/1162 - (39%) Gaps:283/1162 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 SYFGYTLVIRQ-----TSIIVGAPRAQSTLESQRTINETGAIYRC--SLTNGVCSPYVLDSRGNV 108
            |:||:::...:     .||:||||||.:..:     .||||::.|  ....|.|:|.:.|.|   
Mouse    48 SHFGFSVDFHKDKHGSVSIVVGAPRALNASQ-----EETGAVFLCPWKANGGKCNPLLFDLR--- 104

  Fly   109 DAPYSEYTFDSER----------KDFQWLGGSMDGGTKDTDKLLVCAP--RFYAPSSRDNHLH-- 159
                     |..|          |..|.||.|:   ....|.::.|||  .:.....||....  
Mouse   105 ---------DETRNLGFQIFQTFKTGQGLGASV---VSWNDVIVACAPWQHWNVLEKRDEAEKTP 157

  Fly   160 -GVCYWVNNTVASTPQHVTRISPLRLK--SEQVKEEDNGNKASFFYIMGELGLSAHVADDNTKFL 221
             |.|:..........::    ||.|..  |....|...|:|.   |.  |.|.|..|.... :.:
Mouse   158 VGGCFLAQLQSGGRAEY----SPCRANTMSSVYAESFRGDKR---YC--EAGFSLAVTQAG-ELV 212

  Fly   222 IGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQ 286
            :||||...:.|   |..:| |::|..:|.|..:....     |.:..:|.::..|..        
Mouse   213 LGAPGGYFFLG---LLARV-PIENIISSYRPGTLLWH-----VSNQRFTYDNSNPVF-------- 260

  Fly   287 EEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFG 351
             .|.|.||:|:.|.|| .:|:...||:.||..:...|...|.|...:.:|:.|   |||...|||
Mouse   261 -FDGYRGYSVAVGEFD-GDPSTTEYVSGAPTWSWTLGAVEILDSYYQPLHRLH---GEQMASYFG 320

  Fly   352 YSVLAEDLNGDGKTDVIVSAPQHALEDSHDN-----GAIYVFIN-KGFFNFERQILRSP------ 404
            :||...|:||||:.|::|.||.: :|...|.     |.:|:|:. ||     .|.|.:|      
Mouse   321 HSVAVTDVNGDGRHDLLVGAPLY-MESRADRKLAEVGRVYLFLQPKG-----PQALSTPTLLLTG 379

  Fly   405 VETMARFGTALSRLGDINHDGYNDVAVGAPF---AGNGTVFIYLGSENGLRDQPSQRLDAPSQQP 466
            .:...|||:|::.|||:|.|||||:||.||:   :|.|.|.|:||...||..:|||.||:|.  |
Mouse   380 TQLYGRFGSAIAPLGDLNRDGYNDIAVAAPYGGPSGQGQVLIFLGQSEGLSPRPSQVLDSPF--P 442

  Fly   467 SKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESRE-IKP---- 526
            :..|   ||..|....|||.||:.|..:||..|..|.:|||.|||.  |||:...:: :.|    
Mouse   443 TGSG---FGFSLRGAVDIDDNGYPDLIVGAYGASKVAVYRAQPVVM--ATVQLMVQDSLNPTLKN 502

  Fly   527 ---EQEKVKITACYRLST-------TSTDKLVQEQELAIRIAMDKQLKRVKFTQTQTNEISFKVN 581
               :|.|..: :|:.:..       ....||..:.||.:.:...:|.:||....:|...::..::
Mouse   503 CVLDQTKTPV-SCFNIQMCVGATGHNIPQKLHLKAELQLDLQKPRQGRRVLLLASQQASLTLSLD 566

  Fly   582 A---------NFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPK 637
            .         ..|...|| |...|    |..:||.|.::..|     ..||.....|:|...|..
Mouse   567 LGGRDKPICHTTGAFLRD-EADFR----DKLSPIVLSLNVSL-----PPEETGGAPAVVLHGETH 621

  Fly   638 VSTQ-NIIFSTGCATDVCTADLQLRSKDVSPTYILGSADTLRLNYEITNIGETAY-------LPQ 694
            |..| .||...| ..|:|...|:|.:.......::|:.:.|.|..|..|.||.||       ||.
Mouse   622 VQEQTRIILDCG-EDDLCVPQLRLTATAGDSPLLIGADNVLELKIEAANDGEGAYEAELAVHLPP 685

  Fly   695 --------FNVTSTSRLAFAQVPGNCKVVDAVMVCDLNRGRPLAKGDTDSVTISFDVSQL--SGQ 749
                    .|:....||...|...|   ...|.:|:|  |.|:.|.....:|:...|..|  :|:
Mouse   686 GAHYMRALSNIEGFERLVCTQKKEN---ESRVALCEL--GNPMKKDTRIGITMLVSVENLEEAGE 745

  Fly   750 SLIIHAEVFSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQ------------TNSQIDLEHYSNS 802
            |:....:|.|.. .|||........:.::....::..|..            ...|.||:.:.:.
Mouse   746 SVSFQLQVRSKN-SQNPNSKVVMLPVAIQAEATVELRGNSFPASLVVAAEEGDREQEDLDRWVSR 809

  Fly   803 AEIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQ 867
            .|  :.||:.:.||..:..|.:..:||                      ..|..|.||.|     
Mouse   810 LE--HTYELHNIGPGTVNGLRLLIHIP----------------------GQSQPSDLLYI----- 845

  Fly   868 NNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLK 932
                |.|.|       .|||  ...||        .|..|...:.....|.:......|:||.. 
Mouse   846 ----LDVQP-------QGGL--LCSTQ--------PSPKVDWKLSTPSPSSIRPVHHQRERRQA- 888

  Fly   933 ALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTIC--------VRAEMRVHFR 989
                                   ..:|..|       ..:||.:..|        |..|:|...|
Mouse   889 -----------------------FLQGPKP-------GQQDPVLVSCDGSASCTVVECELREMVR 923

  Fly   990 PEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSF----SINRRIEPNIISK 1050
            .:::: :.::..:.|:.:..   .|.|.||:.:.........|.|...    |...|::..::..
Mouse   924 GQRAM-VTVQVMLGLSSLRQ---RPQEQFVLQSHAWFNVSSLPYSVPVVSLPSGQARVQTQLLRA 984

  Fly  1051 HQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDELDRLVQQNPVEPEAE 1107
            .:|..:|:|.::|.|:||||||:.:...::|.|||.|.:.          |:|.:.|
Mouse   985 LEERAIPVWWVLVGVLGGLLLLTLLVLAMWKAGFFKRNRP----------PLEEDEE 1031

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scbNP_523750.2 Int_alpha 51..103 CDD:214549 19/58 (33%)
FG-GAP 350..388 CDD:280083 17/42 (40%)
Int_alpha 409..459 CDD:214549 28/52 (54%)
Int_alpha 473..>515 CDD:214549 19/41 (46%)
Integrin_alpha2 507..829 CDD:285619 85/375 (23%)
Itga2bNP_034705.2 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 35..96 17/52 (33%)
Int_alpha 46..102 CDD:214549 19/58 (33%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 109..173 13/66 (20%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 184..237 17/62 (27%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 252..304 18/61 (30%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 305..370 27/73 (37%)
Int_alpha 315..366 CDD:214549 19/51 (37%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 372..431 26/58 (45%)
Int_alpha 383..437 CDD:214549 28/53 (53%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 434..495 29/67 (43%)
Int_alpha 444..>484 CDD:214549 18/42 (43%)
Integrin_alpha2 480..916 CDD:285619 112/536 (21%)
GFFKR motif 1017..1021 3/3 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167832071
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3637
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.740

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