DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and Itga6

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	XP_038960023.1	Gene:	Itga6 / 114517	RGDID:	621633	Length:	1090	Species:	Rattus norvegicus

Alignment Length:	1215	Identity:	285/1215 - (23%)
Similarity:	488/1215 - (40%)	Gaps:	308/1215 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 HIFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIR-------QTSIIVG 67
            ::...|||.:|  .|||...|...||..        :....|.||::|.:.       :..::||
  Rat    11 YLSAGLLARLS--TAFNLDTREDNVIRK--------SGDPGSLFGFSLAMHWQLQPEDKRLLLVG 65

  Fly    68 APRAQSTLESQRTINETGAIYRCSLTN-GVCSPYVLDSRGNVDA-PYSEYTFDSERKDFQWLGGS 130
            ||||:: |..|:. |.||.:|.|.:|: |.|:..|.|:    || |.      ||.|:.||:|.:
  Rat    66 APRAEA-LPLQKA-NRTGGLYSCDITSRGPCTRIVFDN----DADPM------SESKEDQWMGVT 118

  Fly   131 MD----GGTKDTDKLLVCAPRF-------YAPSSRDNHLHGVCYWVNNTVASTPQHVTRISPLRL 184
            :.    ||     |::.||.|:       ....|||  :.|.||                    :
  Rat   119 VQSQGPGG-----KVVTCAHRYEKRQHVNTKQESRD--IFGRCY--------------------V 156

  Fly   185 KSEQVKEEDNGNKASFFYIMGEL-----------GLSAHVADDNTKFLIGAPGINTWRGSVILYR 238
            .|:.::.||:.:...:.:..|.|           |::|....|....:.||||...|:|.|
  Rat   157 LSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIV---- 217

  Fly   239 QVDPVDNPTASRRDTSKALRRTYRDVDSNDYTP-------EHYAPEIPTPGLWGQEEDSYFGYAV 296
            :|:..:|              |:.|::..:..|       :|....:|.|.      :||.|:::
  Rat   218 RVEQKNN--------------TFFDMNIFEDGPYEVGGETDHDESLVPVPA------NSYLGFSL 262

  Fly   297 SSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKY--HVFRGEQFGEYFGYSVLAEDL 359
            .||....|. ..:.:|:.||:|| .||...:.....||.|..  ::|.||.....|||.|...||
  Rat   263 DSGKGIVSK-DDITFVSGAPRAN-HSGAVVLLKRDMKSAHLLLEYIFDGEGLASSFGYDVAVVDL 325

  Fly   360 NGDGKTDVIVSAPQHALEDSHDNGAIYVFINK--GFFNFERQILRSPVETMARFGTALSRLGDIN 422
            |.||..|:::.|||:...|....||:||:||:  .:.|.:...|....::|  ||.|:..:||||
  Rat   326 NADGWQDIVIGAPQYFDRDGEVGGAVYVYINQQGRWSNVKPVRLNGTKDSM--FGIAVKNIGDIN 388

  Fly   423 HDGYNDVAVGAPFAGNGTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGN 487
            .|||.|:|||||:...|.||||.||..|:..:|:|.|:..:.        .||:.::...|:|.|
  Rat   389 QDGYPDIAVGAPYDDLGKVFIYHGSPTGIITKPTQVLEGTTP--------FFGYSIAGNMDLDRN 445

  Fly   488 GFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEK---------VKITACYR----- 538
            .:.|.|:|: .:::|.::|:.||:.:..|:......|...|:.         :|:.||:.
  Rat   446 SYPDVAVGS-LSDSVTIFRSRPVINILKTITVTPSRIDLRQKSMCGSPSGICLKVKACFEYTAKP 509

  Fly   539 ---------LSTTSTDKLVQEQELAIRIAMDKQLKRVKFTQTQTNEISFKVNANFGEQCRDFETQ 594
                     |.....:|..::..|:.|:....|....|:||..|      :|......|.:....
  Rat   510 SGYNPPISILGILEAEKERRKSGLSSRVQFRNQGSEPKYTQELT------LNRQKQRACMEETLW 568

  Fly   595 VRYSEKDIFTPIDLEMHYELTKKVPDS----EEFCETCAIVDPTEPK-VSTQNIIFSTGCATD-V 653
            ::.:.:|...||.:....|:.:  |.|    ....|...|::..|.| |.|.......||..| |
  Rat   569 LQENIRDKLRPIPITASVEIQE--PSSRRRVNSLPEVLPILNSNEAKTVQTDVHFLKEGCGDDNV 631

  Fly   654 CTADLQLRSKDVS-----------------PTYILGSADTLRLNYEITN----------IGETAY 691
            |.::|:|..|..:                 |..:|.....:.|...:||          .|:.|:
  Rat   632 CNSNLKLEYKFGTREGNQDKFSYLPIQKGIPELVLKDQKDIALEITVTNGPSDPRNPRKDGDDAH 696

  Fly   692 LPQFNVTSTSRL---------AFAQVPGNCKVVDAVMVCDLNRGRPLAKGDTDSVT--------- 738
            ..:...|....|         ||.:...:|.........|...|.|..:  ..|||
  Rat   697 EAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKR--NSSVTFYLILSTTE 759

  Fly   739 ISFDVSQLSGQSLIIHAEVFSTGYEQN--PTDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSN 801
            ::||.:.|.     |:.::.:|..:.|  |...:...||.|.    :..||....||:   ::..
  Rat   760 VTFDTTDLD-----INLKLETTSNQDNLAPITAKAKVVIELL----LSVSGVAKPSQV---YFGG 812

  Fly   802 SAEIVNNYEIKSNGP--SVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDL 864
            :  :|....:||...  |:||           |:........|:.|:.:..:...:..::
  Rat   813 T--VVGEQAMKSEDEVGSLIE-----------YEFRVINLGKPLKNLGTATLNIQWPKEI----- 859

  Fly   865 YDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRR 929
             .....:|.:..||     |.|||:.|...:.:                ::...:..:..|||:|
  Rat   860 -SNGKWLLYLMKVE-----SKGLEQVVCEPHNE----------------INFLKLKESHNSRKKR 902

  Fly   930 DL--KALTANREQYARISNVKAHDLLSDDFKGKLPVN-RTIVFNC----RDPEMTICVRAEM-RV 986
            :|  |.:..:| :::..|..|...|       ...|| |.:...|    .|.:.::.:|:.: ..
  Rat   903 ELPEKQIDDSR-KFSLFSERKYQTL-------NCSVNVRCVNIRCPLRGLDSKASLVLRSRLWNS 959

  Fly   987 HFRPEKS----INLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPNI 1047
            .|..|.|    :::.:|.|:|:.             ....::||...|.....:...::.:.
  Rat   960 TFLEEYSKLNYLDILVRASIDVT-------------AAAQNIKLPHAGTQVRVTVFPSKTVA--- 1008

  Fly  1048 ISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDE 1092
                |.:|:..|||:::|:.|:|:|:.:.:||:|.|||.|::.|:
  Rat  1009 ----QYSGIAWWIILLAVLAGILMLALLVFLLWKCGFFKRSRYDD 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	21/59 (36%)
		FG-GAP	350..388	CDD:280083	17/37 (46%)
		Int_alpha	409..459	CDD:214549	26/49 (53%)
		Int_alpha	473..>515	CDD:214549	12/41 (29%)
		Integrin_alpha2	507..829	CDD:285619	77/399 (19%)
Itga6	XP_038960023.1	Int_alpha	40..100	CDD:214549	21/61 (34%)
		Int_alpha	254..>292	CDD:214549	13/45 (29%)
		Int_alpha	314..364	CDD:214549	20/49 (41%)
		Int_alpha	374..425	CDD:214549	27/52 (52%)
		Integrin_alpha2	464..939	CDD:400650	101/544 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335755
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840