DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and itgam.1

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	XP_005156064.1	Gene:	itgam.1 / 101882585	ZFINID:	ZDB-GENE-110411-175	Length:	1136	Species:	Danio rerio

Alignment Length:	1308	Identity:	265/1308 - (20%)
Similarity:	436/1308 - (33%)	Gaps:	406/1308 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FPHIFLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIR-QTSIIVGAPRA 71
            :.:|.|.:..:...:..||......:...:|        .|.:..|||.::.. .|.:.|..|..
Zfish     5 YSYISLCIFCVPQSVMTFNVDHAAWKTFTAP--------LTNNVAFGYKVIQEDMTRLTVSDPLI 61

  Fly    72 QSTLESQRTIN--ETGAIYRCSLTNGVCS------------------------------------ 98
            |        ||  |.|.||.|.:..|.||
Zfish    62 Q--------INRDERGQIYSCDVNRGTCSSLNIYGRVPSEAVNMSLGLSMVKDPGSSKLVVCGPT 118

  Fly    99 ------------------------------------------PYVLDSRGNVD------------ 109
                                                      .::||..|:||
Zfish   119 IPKNCPGVSTYNGMCFVNEHRRSFTGPIPSSLRECPKSQIDIAFLLDGSGSVDPVDFNKMKAFVV 183

  Fly   110 ---------------APYS-----EYTFDSERKDFQW---------------------------- 126
                           |.:|     .|.|...:....|
Zfish   184 EMIKSFIDRDTQFAIAQFSTECVIHYKFQQVKNPAWWQRAVNGIQQTHGWTFTATAIRLLVESLF 248

  Fly   127 --LGGSMDGGTK---------DTDKLLVCAPRFYAPSSRDNHLHGV-----CYWVNN---TVAST 172
              .||:....:|         ..||.|..|.:.....|...:..||     .|...|   .:||.
Zfish   249 VSSGGARQSASKILVVITDGESNDKFLTEAVQQAQEKSITRYAIGVGNAFNKYSARNELTVIASI 313

  Fly   173 P--QHVTRISPL-RLKS--EQVKE--------EDNGNKASFFYIMGELGLSAHVADDNTKFLIGA 224
            |  :||.:::.. .|:|  |.:||        :.:|:.:...:  .:.|.||.:..| |..::.|
Zfish   314 PTDKHVFKVTDFDALESIREILKENIIAIEGTQTSGDSSRMEF--AQDGFSAALTSD-TDLIMTA 375

  Fly   225 PGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEED 289
            .|...|:|...|::                           .||.|....|         |.|.:
Zfish   376 VGAFQWKGGYQLFK---------------------------LNDQTSVFQA---------GSEHN 404

  Fly   290 SYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKYH----VFRGE------ 344
            ||.||:              |.:||.....        :.|.|...||:.    |.|.:
Zfish   405 SYLGYS--------------LAIATVYNTK--------YAVMGAPRHKHEGLVTVTRIDRMSDQI 447

  Fly   345 -------QFGEYFGYSVLAEDLNGDGKTD-VIVSAPQHALEDSHDNGAIYVFINKGFFNFERQIL 401
                   |.|.|||..|...|||.|..|| ::||||.:...:......:|.:..:.||:|...:|
Zfish   448 QLDPPKTQIGSYFGAEVCVVDLNSDSNTDLLLVSAPTYTESEREGKVFVYSYTRRPFFSFSDVVL 512

  Fly   402 RSPVETMARFGTALSRLGDINHDGYNDVAVGAPFA--GNGTVFIYLGSENGLRDQPSQRLDAPSQ 464
            ........|||::|:...|:|.||:.||.||||..  |.|:::|:.|.:.|:....|||:...|.
Zfish   513 VGMAGQRGRFGSSLASPADLNGDGFKDVLVGAPLEEDGKGSIYIFNGRDGGIISSYSQRIAGSSV 577

  Fly   465 QPSKYGSHMFGHGLSRGS-DIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIK--- 525
            |.   |...||..||:.| |...:...|.|:|:..  ||.|.|:.|::.:...|.....:|.
Zfish   578 QS---GLQYFGVSLSQSSPDQTADSLPDIAVGSKG--AVLLLRSRPIMLLETKVSYNPSKISTGH 637

  Fly   526 ---PEQEKVKITACYRLSTTSTDKLVQEQELAIRIAMD-KQLKRVKFTQTQTNEISFKVNANFGE 586
               ..|.:..:..|:.:......|.....::...|.:| |:.....|...:.|.:|..::....|
Zfish   638 TDCKNQLQTTLIVCFTMKGYRHHKRDLNAKITYNITLDAKRQNHRAFFSAKDNLLSNVIDIGNTE 702

  Fly   587 QCRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQNIIFSTGCAT 651
            .|::.:..:....:|...|:..::.:.. :.:| |.:......|:.|.....|..::.|...|..
Zfish   703 VCKNHDFLIEACPEDALNPLSNQLKFTF-EGLP-SSQMQNLRPILLPEIKTTSDHDLDFERECGK 765

  Fly   652 D-VCTADLQLRSKDVSPTYI-LGSADTLRLNYEITNIGETAYLPQFNVT-----STSRLAFAQVP 709
            | ||..:|::.......|.| :|....:.:...:.|.||.:|...|.:.     |..|:...|..
Zfish   766 DNVCVDNLRVDFNFSGSTNIEVGIMQEINVTVFVENRGENSYNTHFTLNYPYGFSYRRITSKQGR 830

  Fly   710 GNCKVVDAVMVCDLNR-----GRPLAKGDTD---SVTISFDVSQLSGQSLIIHAEVFSTGYEQNP 766
            ..|..:|......|..     .:|:.|.:|.   .:|.|.:.....||::|..|.| .:|.:::.
Zfish   831 VECSSLDGEQGVRLGETECAISKPILKDNTKIVFEITYSINKEVTLGQNVIFSASV-KSGNDKHS 894

  Fly   767 TDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYSNSAEIVNNYEIKSNGPSVIEQLTVSF---YI 828
            ..:.      |.:...||...|   ..:.|..:.||...:|....|.:....::| |:..   ..
Zfish   895 ESSE------LSKKKSIDVKYG---IYVALIRHENSTIHINFTSGKKDLSKPVQQ-TIKIENDLR 949

  Fly   829 PIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERTVIT 893
            |:|:     ||.|.:    .||        |...|:: :.:|:.|.|.|:..|      |:..:|
Zfish   950 PLAF-----TAFIRV----PLK--------LGDTDIW-KESTLQVSDCVKNKT------EKPSVT 990

  Fly   894 QNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISN--VKAHDLLSDD 956
            ........|   ||......:....:...::.:..|.|..:|.|      :|:  ::...|.|..
Zfish   991 NYMDDIKKH---HVLNCSVAVCAVFICDVNLIKNERKLYNITGN------VSSAWIEQTGLKSAV 1046

  Fly   957 FKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVIL 1021
            |:   .|:.|.:    |.:|:..|       |....|.|
Zfish  1047 FE---LVSTTTM----DYDMSTYV-------FFSSDSRN-------------------------- 1071

  Fly  1022 TDLKLQKKGDPTSTSFSINRRIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFN 1086
                       |:.|..|:.::|     .::|..| ...||..|||||:||:.|:..|||.|||.
Zfish  1072 -----------TAPSLQISTQVE-----VYEEVDL-TKEIIGGVIGGLVLLALITAALYKAGFFK 1119

  Fly  1087 RTKKDELD 1094
            ...|..::
Zfish  1120 SQYKQMME 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	17/132 (13%)
		FG-GAP	350..388	CDD:280083	14/38 (37%)
		Int_alpha	409..459	CDD:214549	21/51 (41%)
		Int_alpha	473..>515	CDD:214549	14/42 (33%)
		Integrin_alpha2	507..829	CDD:285619	63/346 (18%)
itgam.1	XP_005156064.1	vWFA	158..331	CDD:294047	28/172 (16%)
		Int_alpha	456..>498	CDD:214549	15/41 (37%)
		Int_alpha	520..572	CDD:214549	21/51 (41%)
		Integrin_alpha2	616..>908	CDD:285619	55/300 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574954
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23220
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840