DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and itga2

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	XP_031750117.1	Gene:	itga2 / 100492714	XenbaseID:	XB-GENE-982743	Length:	1172	Species:	Xenopus tropicalis

Alignment Length:	1349	Identity:	272/1349 - (20%)
Similarity:	473/1349 - (35%)	Gaps:	429/1349 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AESTMFPHIFLALLA--LISHIEAFNFMPRPSRVINSPKHLKF--HINQTRSSYFGYTLVIRQTS 63
            |.:|..|.:.|.:|.  |:.|.||:|.....:::.:.|.:.:|  .:.|..:....:.||....|
Frog     2 ARTTCIPWLLLVILQGNLLKHSEAYNVGLSGAKIYSGPANTQFGYSVQQFHNQDGNWLLVSSPWS 66

  Fly    64 IIVGAPRAQSTLESQRTINETGAIYRCSLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLG 128
               |.|:           |..|.||:||:::   |....|.....||......  :|:::...||
Frog    67 ---GYPK-----------NRMGDIYKCSVSS---STTKCDKMNLADATIIPNV--TEKREEMNLG 112

  Fly   129 GSM--DGGTKDTDKLLVCAPRFYAPSSRDNHLHGVC----------------------------- 162
            .::  :|   :|...|.|.|.:......:.:..|||
Frog   113 LTLLRNG---NTGGFLACGPLWAQQCGNNYYATGVCSDVSPSFKVIRSFSPALQTCSSYIDIAIV 174

  Fly   163 ----------YWVNNTV-----------AST----------PQHVTRISPLRLKSEQVK------ 190
                      |.|.|.:           :||          ||.:.::...|.|.|..|
Frog   175 CDGSNSIYPWYAVRNFLEKFVQGLDIGPSSTQVSLIQYGNDPQVMYKMDTYRTKEEMAKAITGID 239

  Fly   191 --------------------------------------------------------EEDN----- 194
                                                                    |:||
Frog   240 QMGGTQTNTFKAIDFTRKFAFSKEYGGRPNANKVMVVITDGESHDNALLSKVIGDCEKDNIIRFG 304

  Fly   195 --------------------------GNKASFFY------------------------------- 202
                                      ..|..||:
Frog   305 IAVLGYYNRYNIDSKNLIKEIESIASVPKEKFFFNVSDEVALLEKAGTLGERIFSIEGTTQGGET 369

  Fly   203 ---IMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYR----QVDPVDNPTASRRDTSKALRRT 260
               .|.::|.||..:::....::||.|...|.|:|:..:    .|.|.           ||..:.
Frog   370 FQMEMSQVGFSAQYSENQGTLMLGAVGAYDWSGTVVHEKAKQFSVFPY-----------KAFEKV 423

  Fly   261 YRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEA 325
            ..|                      :.:.||.||:|:  ..:..|...  :||.||:.: .:|:.
Frog   424 LHD----------------------RNQSSYLGYSVA--VINMKNSVN--FVAGAPRTD-YTGQV 461

  Fly   326 YIFDVRGK-SIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDV-IVSAPQHALEDSHDNGAIYVF 388
            .::::..: ::....:.||||.|.|||..:.:.|:|.|..||| :|.||....|...:.|.:|:|
Frog   462 VVYNITSRGNVSVIQIQRGEQIGSYFGSVLCSVDVNRDSITDVLLVGAPTFMNEYKKEEGQVYMF 526

  Fly   389 INKGFFNFERQILRSP--VETMARFGTALSRLGDINHDGYNDVAVGAPF--AGNGTVFIYLGSEN 449
            ..:.....:|:.|..|  :|. .|||:|::.|.||:.||||||.||||.  ..:|.::|:.|::|
Frog   527 SIRDGILVQREQLEGPKSLEN-TRFGSAIAELSDIDLDGYNDVIVGAPLENQNSGAIYIFNGNQN 590

  Fly   450 GLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPV-VKV 513
            .:|.:.||::...|..|   |...||..:....|::|:..||.::|| ..:|:.|:..:.. |.|
Frog   591 TIRTKYSQKILGSSFNP---GLQYFGRSVDGHQDLNGDTINDVSVGA-YGKAIQLWSQHIADVSV 651

  Fly   514 HATVKSESREIKPEQEKVKITACYRLSTTSTDKLVQEQELAI--RIAMDKQLKRVKFTQ----TQ 572
            .|....:...:..:..:|.:..|:......|:   .:..:|:  ...:|..|...:.|.    .:
Frog   652 KAIFIPQQIILTNKNCEVTVRICFSAVFRPTN---SQNSVAVTYNATLDADLLSSRVTSRGQFRE 713

  Fly   573 TNEISFKVNANFG--EQCRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTE 635
            :|:...:.|...|  |.|.:....|:.:..   |...|.:...:..:.|.      |..:::|..
Frog   714 SNDRFLQRNIAIGPTESCFEHIFNVQETSN---TENALALRINVIAQNPG------TSPVLNPYS 769

  Fly   636 PKVSTQNIIFSTGCATD-VCTADLQLR----SKDVSPTYILGSADTLRLNYE--ITNIGETAYLP 693
            ...:...|.|...|..| :|.:||.|:    ..|:...||:...|. ||.::  :||..|.||..
Frog   770 SSSTEWFIPFLKDCGDDKICISDLSLQIQQIPNDIKLPYIVSMKDR-RLLFQVTVTNKQENAYNT 833

  Fly   694 QFNVTSTSRLAFAQ--VPGN-----CKVVDAVMVCDLNRGRPLAKGDTDSVTISFDV------SQ 745
            :.|...:..|.||.  .|.:     |:|.:|........|.|..|   |...:.||:      :.
Frog   834 RLNAVFSENLFFASSTTPRDGTEVLCQVGNAQNSVSCLIGFPFLK---DGQKVIFDIWFDFNLNN 895

  Fly   746 LSGQSLIIHAEVFSTGYEQNPTDNRQT----NVIGLKEFTEIDASGGQTNSQIDLEHYSNSAEIV 806
            |..::.|         |.|..:|:|:.    |.:.:....:.||       :|.|...:|    :
Frog   896 LQNKAFI---------YFQTMSDSREARENDNSVNISLPVQYDA-------EIHLTREAN----I 940

  Fly   807 NNYEI--KSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDL---YD 866
            |.||:  ..|.|||:.:.. ...:...:.|..||..:|:            .:..|||::   ..
Frog   941 NFYEVFPGLNIPSVVNKFD-DIGLEFNFSVKVSTGTVPL------------KTAFLSINVPQFTK 992

  Fly   867 QNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTM---EVLDTSM-VATASMSRK 927
            .||.:|.:..|: |..:||      ::.|......|.....::|.   |.|...: ..:|..:..
Frog   993 SNNPLLYITSVQ-TDQMSG------VSCNANINPDHIGRIPYETSFKEENLKNELNCKSARCAAI 1050

  Fly   928 RRDLKALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPEMTICVRAEMRVHFRPEK 992
            :..|:.|....:.|..:|                    |.::|          ......||   :
Frog  1051 QCSLEGLQLREDYYVNVS--------------------TRIWN----------GTFAAAHF---Q 1082

  Fly   993 SINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPNIISKHQETGLP 1057
            :|.|.....::..:....::...:..:.||..|..:|.:                        :|
Frog  1083 TIELVANAKIETMDSEIFVISNKDAMIPLTITKPGEKSE------------------------VP 1123

  Fly  1058 IWIIIVSVIGGLLLLSAISYLLYKFGFFNR------TKKDELDRLVQQN 1100
            |.|:|.|.|.||:||:|:..||:|.|||.|      ..::|:....|.|
Frog  1124 IGIVIGSAIAGLVLLAALVALLWKLGFFKRKYQKLQKTEEEIAETTQLN 1172

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	12/51 (24%)
		FG-GAP	350..388	CDD:280083	14/38 (37%)
		Int_alpha	409..459	CDD:214549	24/51 (47%)
		Int_alpha	473..>515	CDD:214549	12/42 (29%)
		Integrin_alpha2	507..829	CDD:285619	73/356 (21%)
itga2	XP_031750117.1	Int_alpha	40..88	CDD:214549	14/64 (22%)
		vWFA	169..349	CDD:412136	17/179 (9%)
		Int_alpha	431..473	CDD:214549	11/46 (24%)
		Int_alpha	483..531	CDD:214549	17/47 (36%)
		Int_alpha	547..600	CDD:214549	24/53 (45%)
		Int_alpha	610..>634	CDD:214549	6/23 (26%)
		Integrin_alpha2	643..1052	CDD:400650	93/464 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100