Protein Alignment scb and itga4

DIOPT Version :9

• Sequence 1: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Sequence 2: XP_002932062.3
• Gene: itga4 / 100487924
• XenbaseID: XB-GENE-960093
• Length: 1030
• Species: Xenopus tropicalis
• Alignment Length: 1129
• Identity: 273/1129 - (24%)
• Similarity: 464/1129 - (41%)
• Gaps: 260/1129 - (23%)

  Fly    48 TRSSYFGYTLVIRQTS----IIVGAPRAQSTLESQRTINETGAIYRCSL---TNGVCSPYVLDSR 105
            ::.|.||:::|:....    |:||||::..|   .:.:...|||.:|.:   .||.|....|
 Frog    46 SQGSLFGFSVVLHSNGDGNWIVVGAPQSSWT---TKNVTNPGAILKCRIEQNPNGSCDVLEL--- 104

  Fly   106 GNVDAPYSEYTFDSERKDFQWLGGSMDGGTKDTDKLLVCAPRFYAPSSRDNHL--------HGVC 162
            ||::......|. .|.:|.||||.|:...:....::|.|..|:     ::.|.        :|||
 Frog   105 GNLNGAKCGKTC-KEEQDNQWLGVSLSRQSTKDGQILACGHRW-----KNIHFMLSDHKLPYGVC 163

  Fly   163 YWVNNTVASTPQHVTRISPLRLKSEQVKE-----EDNGNKASFFYIMGELGLSAHVADDNTKFLI 222
            |.:               |...::|..|.     :|:..|....|...:.|:|....:|  ..::
 Frog   164 YGI---------------PANFRTELSKRICPCYKDHVRKFGDSYGSCQAGISTFYVED--VIVM 211

  Fly   223 GAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQE 287
            ||||...|.||:.:|   :..:|...|..|.:.|::                         :|
 Frog   212 GAPGSFYWTGSIFVY---NTTENTIKSYVDLNNAVK-------------------------FG-- 246

  Fly   288 EDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGY 352
              ||.||:|.:|.|.:.|..::  :..||| .:|:|:||||....|.:.......|::.|.|||.
 Frog   247 --SYLGYSVGAGHFRTPNSYEV--IGGAPQ-QEQTGKAYIFTYEEKQLVILFEAGGKKLGSYFGA 306

  Fly   353 SVLAEDLNGDGKTDVIVSAPQHALEDSHDNGAIYVFINKG-----FFNFERQILRSPVETMARFG 412
            :|.|.||||||.:|::|.||..:  ...:.|.::|::|.|     ...||   |.......||||
 Frog   307 AVCAVDLNGDGLSDLLVGAPMQS--TIREEGRVFVYMNTGGGAMEELQFE---LSGSDLYAARFG 366

  Fly   413 TALSRLGDINHDGYNDVAVGAPFAGN--GTVFIYLGSENGLRDQPSQRLDAPSQQPSK--YGSHM 473
            ..::.||||::||:.|||:.||..|:  |.|:||.|.|.|:....||||     |.||  ||..|
 Frog   367 DTIANLGDIDNDGFEDVAIAAPQEGDLEGAVYIYNGREKGITPSFSQRL-----QGSKFGYGLRM 426

  Fly   474 FGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHATVKSESREIKPEQEKVK------ 532
            ||..:|...||||||:||.||||..:::..|.|..||:.:.|::|......|...|.::
 Frog   427 FGQSISNVLDIDGNGYNDVAIGAFLSDSAVLLRTRPVIVIDASLKLPMTVNKTRFECMENGAPAV 491

  Fly   533 ---ITACYRLSTTSTDKLVQEQELAIRIAMDKQLK-----RVKFTQTQTNEI---SFKVNANFGE 586
               :|.|:..........:   .:...|..|.:.|     |..|....|:::   :..::...|
 Frog   492 CMNVTICFAYKGLDVPGYI---VMYYNITSDVRRKSGTPARFYFVSNGTSDVMSGTMNIHQKSG- 552

  Fly   587 QCRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEP---------KVSTQN 642
            .|:..:..:|...:||||||.:|..|.|.|.:.......:    :.|.:|         .|.|..
 Frog   553 NCKTHKAFMRKDTRDIFTPIHMESSYYLGKHIVSKRSADD----LQPLQPVLQQKEGKGNVITNK 613

  Fly   643 IIFSTGCATDVCTADLQLRSKDVSP------TYI-LGSADTLRLNYEITNIGETAYLPQFNVTST 700
            :.|:..|....|:||||:..|...|      .|: :|...:|.:|..:.|.|:.|:.....:...
 Frog   614 VHFARHCTLLNCSADLQITGKLSFPKPFESKLYLAVGGMKSLMINITLFNGGDDAFQTVLQLRLP 678

  Fly   701 SRLAFAQVPGNCKVVDAVMVCDLNRGRPLAKGDTDSVTIS-----FDVSQLSGQ--SLIIHAEVF 758
            ..|.|.:|   ..:::..:.|.:|      |.:.:...:.     |.|...|.|  |.::.:...
 Frog   679 KGLYFVKV---FDMLEKEISCAVN------KEENEQTRLDCSVGHFYVDAFSKQEFSFLLDSSAL 734

  Fly   759 STGYEQ---NPTDNRQTNVIGLKEFTEIDASGGQ------TNSQIDLE---HYSNSAEIVNNYEI 811
            :...|.   |.|      |....||||......:      |..:|||.   ..|..:.:...:|.
 Frog   735 TRAEEDLVINAT------VACENEFTEDTIWNNEVSFIVPTRYEIDLNVLGTVSPFSFVFGPHED 793

  Fly   812 KSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDP 876
            :.:|..::|::..:|.:     :...::::|     :.|:|.|..:..       ..|.:.::|.
 Frog   794 EPDGACIMEKIEFTFNV-----INAGSSLVP-----AAKLQISLPNTF-------SPNGVKLLDI 841

  Fly   877 VEVTTTLSGGLERTVITQNRQSYDIHTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTANREQY 941
            :.|.||:           ....:|.:|.|             ..|...:|.
 Frog   842 LAVKTTV-----------GECYFDNYTRG-------------CETPKNTRS-------------- 868

  Fly   942 ARISNVKAHDLLSDDFKGKLPVNRTIVFNCRDPE--MTICVRAEMRVHFRPEKSINLNMRYS-VD 1003
                  |..||.:  |..: |..|.:.....||.  ..:|:..:|....:....:.|.:.:| ::
 Frog   869 ------KVGDLFA--FFSR-PDKRWLYCMKDDPSCIQILCLFGDMERESKATVEVQLEISHSYLE 924

  Fly  1004 LNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPNII----SKHQETGLPIWIII-V 1063
            .:|...|     ::|.     ..|...:.:....::|:.....::    ..|:.....|::|| :
 Frog   925 TDEATLI-----QFFT-----TAQAGFEDSPKIINLNQDHHAYVVLEALHNHKPKKHVIYLIIGI 979

  Fly  1064 SVIGGLLLLSAISYLLYKFGFFNR 1087
            |::.|:||.|.::|:|:|.|||||
 Frog   980 SLLLGILLFSLLTYILWKVGFFNR 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	17/58 (29%)
		FG-GAP	350..388	CDD:280083	15/37 (41%)
		Int_alpha	409..459	CDD:214549	25/51 (49%)
		Int_alpha	473..>515	CDD:214549	20/41 (49%)
		Integrin_alpha2	507..829	CDD:285619	75/373 (20%)
itga4	XP_002932062.3	Int_alpha	47..98	CDD:214549	15/53 (28%)
		Int_alpha	301..347	CDD:214549	20/47 (43%)
		Int_alpha	363..415	CDD:214549	25/51 (49%)
		Int_alpha	426..>464	CDD:214549	19/37 (51%)
		Integrin_alpha2	460..899	CDD:400650	97/525 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23220
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4612
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.050