Protein Alignment scb and itga4

DIOPT Version :10

• Sequence 1: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Sequence 2: XP_068079775.1
• Gene: itga4 / 100331333
• ZFINID: ZDB-GENE-110411-108
• Length: 1018
• Species: Danio rerio
• Alignment Length: 1175
• Identity: 295/1175 - (25%)
• Similarity: 490/1175 - (41%)
• Gaps: 277/1175 - (23%)

  Fly    12 FLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVIRQ----TSIIVGAPRAQ 72
            |..|..|:...:.:|.......|.|.|          ..|.|||::::.|    |.::||||.|.
Zfish    17 FGILWYLLILCDCYNLDVEHPLVFNGP----------NGSLFGYSVLLHQHNENTWLLVGAPVAN 71

  Fly    73 STLESQRTINETGAIYRCSLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLGGSMDGGTKD 137
            |:.  ...|...||||.||:.|..|....:   |.|.........::   |.||||.|:   ::.
Zfish    72 SSF--YPNIKSPGAIYNCSMLNSQCEQLPV---GGVQRCGRHCLAEN---DNQWLGVSL---SRQ 125

  Fly   138 TDK--LLVCAPR----FYAPSSRDNHL-HGVCYWVNNTVASTPQHVTRISPLRLKSEQVKEEDNG 195
            ..|  :|.|..|    ||:.....|.| ||||:..:..:    :|.:.|.|.        .:|:.
Zfish   126 ASKGHVLACGHRWKNVFYSSKDNQNKLPHGVCFRFSPDL----KHASHIIPC--------YKDHQ 178

  Fly   196 NKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRT 260
            .:....|...:.|:|....:|  ..::||||.:.|.|||::.              :|:..:...
Zfish   179 RRFGEGYGSCQAGISNSFTED--LMVMGAPGTSYWTGSVLVV--------------NTTSNISAA 227

  Fly   261 YRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEA 325
            |.|.||:              .|:|    ||.||:||:|.|.....|::  |..||| ::|:|:|
Zfish   228 YVDDDSD--------------VLYG----SYLGYSVSAGHFLDPQSTEI--VGGAPQ-HEQTGKA 271

  Fly   326 YIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDSHDNGAIYVFIN 390
            |||.:.|.::...:..:|:..|.|:|.||.|.|||.||.:|::|.||.  .....:.|.:||:||
Zfish   272 YIFRIEGNTLKIVNKTKGKTLGSYYGASVCAVDLNADGLSDLLVGAPM--FSSVREEGRVYVYIN 334

  Fly   391 KGFFNFERQILRSPVETM------ARFGTALSRLGDINHDGYNDVAVGAPFAGN--GTVFIYLGS 447
            :|    |.::..:..|.:      ||||..:..||||:.|||.|||:|||...:  |.::||.|.
Zfish   335 QG----EAELKEADFELVGSDSYAARFGETIINLGDIDDDGYPDVAIGAPQEDDLRGAIYIYNGR 395

  Fly   448 ENGLRDQPSQRLDAPSQQPSKYGSH--MFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPV 510
            .:|:....|||:..     |..|::  |||..:|.|.|||.|.:.|.|:||..:::..::|..||
Zfish   396 RSGIARSFSQRITG-----SLLGNNFRMFGQSVSGGVDIDSNNYPDVAVGAFLSDSAVVFRTRPV 455

  Fly   511 VKVHATV---KSESREIKPEQEK------VKITACYRLSTTSTDKLVQEQELAIRIAMDKQLK-- 564
            |||.|.:   :|.:|.:....|.      :|:..|:|:   ...::....||...:..|...|
Zfish   456 VKVDAVMLLPESLNRSVAQCTENGQPAVCIKVRVCFRV---RGKQIPGNIELKYNLTADVHHKEG 517

  Fly   565 ---RVKFTQTQTNEISF-KVNANFGEQ--CRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEE 623
               |..|:...|:.::. :|.|.. ||  |...:..::...:||||||..|:.|||.:......:
Zfish   518 FPSRFYFSGNGTSNVTAGRVKAKH-EQLTCVFHQAFMKKDVRDIFTPIHFEVKYELGEHRVVQRD 581

  Fly   624 FCETCAIVDPTEPKVSTQNI-----IFSTGCATDVCTADLQL-------RSKDVSPTYILGSADT 676
            ..:..|:....:.|....|:     ||:..|:.:.|:.:||:       :|.:..|.:.||:..:
Zfish   582 LGDLPALKPILQQKDELDNVIKNKTIFARYCSWENCSTNLQVSARLVLPQSYNKMPYFALGNGKS 646

  Fly   677 LRLNYEITNIGETAYLPQFNVTSTSRLAFAQVPGNCKVVDAVMVCDLNRGRPLAKGDTDSV---- 737
            :.||..:.|.|:.|:||:.::...|.|.|.:|....|:|.    |::.....||.|...||
Zfish   647 IMLNTTLLNTGDDAFLPKLHLRFPSNLHFIKVLEEDKLVS----CEIVEENKLAIGLDCSVGNLY 707

  Fly   738 ---------TISFDVSQ-LSGQSLIIHAEVFSTGYEQNPTDNRQTNV----IGLKEFTEIDASG- 787
                     |...||.| .|...|.::....|..:|.  .|.:..||    :.|:...:::..|
Zfish   708 MPPFSKLNITFLLDVMQNSSAGDLTVNINATSENFEN--ADLQHDNVAALTLPLRYAVDMNVHGF 770

  Fly   788 --------GQTNSQIDLEHYSNSAEIVNNYEIKSNGPSVIEQLTVSFYIP---IAYKVAGSTAII 841
                    |:..| :.::.|......  .|::.:.|||......|...:|   :.||       .
Zfish   771 VSPNLFIIGEEES-VPVDCYPEKFNY--TYKVMNIGPSKARDARVKISLPLMLVLYK-------H 825

  Fly   842 PIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERTVITQ-----NRQSYDI 901
            .:|.:|.::....:        .:.:|||:.::|..:|.       |.:||.:     :.:|..|
Zfish   826 QLIRITDIQSTLGH--------CFQRNNTIHIIDDCDVP-------EASVIQELVFFFSPKSKRI 875

  Fly   902 HTSGHVHQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDFKGK-LPVNR 965
            ...|...||...::                          .|..:::|         || :.:|.
Zfish   876 MFCGPEDQTCRTVE--------------------------CRFGDLEA---------GKEVTINM 905

  Fly   966 TIVFNCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDL----NEVNAILVDPWEYFVILTDLKL 1026
            .:..|.|..:|:....|.|.:|            .|:||    .:.|..|:..
Zfish   906 EVELNPRVLQMSPGRHAVMMIH------------GSIDLISPVRDANTFLLQD------------ 946

  Fly  1027 QKKGDPTSTSFSINRRIEPNIISKHQE-TGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKK 1090
                       .::.|:....:..|.. ..:.|:||:.|:|.||::...:...|:|.|||.||.|
Zfish   947 -----------DVSARVMVEALYTHNPGPVVRIFIIVSSLIVGLIIFGLLVLTLWKLGFFKRTLK 1000

  Fly  1091 DELDR 1095
            ::..|
Zfish  1001 EKFRR 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	21/55 (38%)
		FG-GAP	350..388	CDD:460357	15/37 (41%)
		Int_alpha	409..459	CDD:214549	24/51 (47%)
		Int_alpha	473..>515	CDD:214549	19/41 (46%)
		Integrin_alpha2	509..829	CDD:462478	87/375 (23%)
itga4	XP_068079775.1	Int_alpha	44..99	CDD:214549	21/56 (38%)
		Int_alpha	238..281	CDD:214549	21/49 (43%)
		Int_alpha	293..>336	CDD:214549	20/44 (45%)
		Int_alpha	355..407	CDD:214549	24/51 (47%)
		Int_alpha	415..>460	CDD:214549	19/44 (43%)
		Integrin_alpha2	453..845	CDD:462478	92/419 (22%)