DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and itgav

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	NP_001028893.1	Gene:	itgav / 100151255	ZFINID:	ZDB-GENE-060616-382	Length:	1045	Species:	Danio rerio

Alignment Length:	1181	Identity:	309/1181 - (26%)
Similarity:	491/1181 - (41%)	Gaps:	240/1181 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ALLALIS--HIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVI-----RQTSIIVGAPRA 71
            ||:||.:  ...|||.......|.:.|.          .||||:::..     .|.:|:||||||
Zfish    12 ALVALFTTKRAPAFNLDISKPTVFSGPP----------GSYFGFSVAFFNPDNSQFNILVGAPRA 66

  Fly    72 QSTLESQRTINETGAIYRCS-LTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLGGSMDGGT 135
            .::.::...:.|.||::.|. ..:|.|:....||..  |..:|... ..|.|..||.|.::   .
Zfish    67 NTSDQTPSAVTERGAVFSCPWQKSGTCTQIQFDSTD--DRKHSNGQ-QMEFKSNQWFGATV---R 125

  Fly   136 KDTDKLLVCAPRF----YAPSSRDNHLHGVCYWVNNTVASTPQHVTRISPLRLKSEQVKEEDNGN 196
            ...|::|.|||.:    |..|.|:.  .|.||      .....::...||.|.||.  ..|..|
Zfish   126 SSGDQILACAPLYQWSTYGFSEREP--VGTCY------LKKGNNIVEYSPCRSKSN--SPEGQG- 179

  Fly   197 KASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRDTSKALRRTY 261
                   ..:.|.||.....| :.:||.||...|:|.:|              ..|.::.:.|..
Zfish   180 -------FCQAGFSADFVKKN-RVVIGGPGSFYWQGQLI--------------SDDVTEVINRYN 222

  Fly   262 RDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQANKQSGEAY 326
            :|.    .||  |:.::.|.....|.:|||.||:|:.|.|:......  ||...|:..|..|...
Zfish   223 KDF----LTP--YSNQLSTKPAGAQYDDSYLGYSVAVGDFNEDGEDD--YVTGVPRGEKALGYVN 279

  Fly   327 IFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALEDS----HDNGAIYV 387
            ||:  |:::...:.|.|.|...|||:||.|.|:|.|||.|:.|.||......|    .:.|.:||
Zfish   280 IFN--GRNMESMYNFTGTQMAAYFGHSVAAVDVNNDGKMDLFVGAPLFMDRGSDGKLREVGQVYV 342

  Fly   388 FINKGFFNFERQILRSPVETMARFGTALSRLGDINHDGYNDVAVGAPFAG---NGTVFIYLGSEN 449
            ::.||.|.|...|..:..|..||:|:::..:||:|.|||||||:.||:.|   .|.|:|:.|...
Zfish   343 YLGKGGFTFNSVIKLTGSEIYARYGSSVCSVGDLNMDGYNDVAIAAPYGGPFHRGLVYIHNGRST 407

  Fly   450 GLRDQPSQRLD---APSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVV 511
            |.....||.|:   |....||.     ||:.::.|:|:|.||:.|..:||..|:...||||.||:
Zfish   408 GPNPVASQVLEGTWASVSMPSS-----FGYSMNGGTDVDQNGYPDLIVGAFGADKAILYRARPVI 467

  Fly   512 KVHATVKSESREIKPEQEKVKI----------TACYRLSTT---STDKLVQEQELAI-RIAMDKQ 562
            .|:.|:....:.:.||.:...:          |..|.|..:   :...|:.:.:|.: |:.....
Zfish   468 SVNTTLDISPQILNPEDKSCTLPGTATKVSCFTVKYCLKASGKGAPSSLLFQVDLTLDRLKHKGA 532

  Fly   563 LKRVKFTQTQTNEIS--FKVNANFGEQCRDFETQ-VRYSE-KDIFTPIDLEMHYELTKKVPDSEE 623
            :|||.|...:.:..|  ..||.|.|..|.:.:.. :..|| :|..|||.:.|.|.|..|  .:.:
Zfish   533 IKRVLFLYNKMSHYSKNMTVNNNQGLACEELQAYLIDDSEFRDKITPISVFMEYSLDYK--SAAD 595

  Fly   624 FCETCAIVDPTEPKVSTQNIIFSTGCATD-VCTADLQLR-SKDVSPTYILGSADTLRLNYEITNI 686
            ......|:|.:.|...|:.......|..| :|..||:|. ..|.:..|| |..:.|.|.....|.
Zfish   596 KTGLLPILDQSAPTNVTKQAHILLDCGEDNICKPDLKLSVVSDQNEIYI-GDDNPLTLEVTAENG 659

  Fly   687 GETAYLPQFNVTSTSRLAFAQVPGNCKVVD------------AVMVCDLNRGRPLAKGDTDSVT- 738
            ||.||.....||..|:..|..|..|.:.:.            .|:||||  |.|: ||.|..|.
Zfish   660 GEGAYEADLIVTLPSQADFTAVVRNSETLSRLSCAFKKDNQTRVVVCDL--GNPM-KGGTKIVAG 721

  Fly   739 ISFDVSQLSGQSLIIH--AEVFSTGYEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQIDLEHYS- 800
            :.|.|.|||.|...:.  .::.||. :.|.|.|..:.|..|....:::..|.....|:.|...:
Zfish   722 LRFSVHQLSEQDTEVKFGLQIQSTN-QFNNTSNLVSVVTKLAVLAKVELRGVSAPEQVFLPIANW 785

  Fly   801 ----------NSAEIVNN-YEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPIINVTSLKMQAS 854
                      :...:|.: ||:::.|||...:..:....|..:. .||...|...:|.. .|..|
Zfish   786 QPKENPVLEDDIGPLVQHIYELRNKGPSTFSKAILDVQWPYRFN-NGSLLYITKFSVDG-NMNCS 848

  Fly   855 YDSQLLSIDL-----YDQNNTMLVVDPVEVTTTLSGGLERTVITQNRQSYDIH----TSGHVHQT 910
            .:.:|..:::     .|||:           |:.||       .:.|..:::|    ...|..:.
Zfish   849 SNRELNPLNVTSPRFLDQND-----------TSASG-------AEGRNRHNVHRRDLEEKHGEEN 895

  Fly   911 MEVLDTSMVATASMSRKRRDLKALTANREQ--------YARISNVKAHDLLSDDFKGKLPVNRTI 967
            :|:||..       :.:.:::|......|:        |:|                 |.||..:
Zfish   896 LEILDCG-------NAECQEIKCFVGRLEKGQSAILFIYSR-----------------LAVNTFL 936

  Fly   968 VFNCRDPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDP 1032
            ....::....:...|...|...|.|::|..:                                 |
Zfish   937 KAESQNKSYIVRSSASFSVIEMPYKNLNPEL---------------------------------P 968

  Fly  1033 TSTSFSINRRIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTKKDELDRLV 1097
            |||. |.:.::   |.:......:|.|::.::|:.|||||:.:.:::||.|||||.:..:.|| .
Zfish   969 TSTQ-SASLKV---IWNSENPQPVPGWVVALAVLAGLLLLALLIFVMYKLGFFNRVRPPQEDR-T 1028

  Fly  1098 QQNPVEPEAEN 1108
            ::..::|: ||
Zfish  1029 EKEQLQPQ-EN 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	18/57 (32%)
		FG-GAP	350..388	CDD:280083	17/41 (41%)
		Int_alpha	409..459	CDD:214549	23/52 (44%)
		Int_alpha	473..>515	CDD:214549	18/41 (44%)
		Integrin_alpha2	507..829	CDD:285619	93/368 (25%)
itgav	NP_001028893.1	Int_alpha	39..99	CDD:214549	18/69 (26%)
		VCBS	255..320	CDD:290251	24/68 (35%)
		Int_alpha	297..>345	CDD:214549	19/47 (40%)
		Int_alpha	362..417	CDD:214549	23/54 (43%)
		Int_alpha	426..>470	CDD:214549	19/48 (40%)
		Integrin_alpha2	463..911	CDD:285619	113/481 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574886
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740