DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scb and itga8

DIOPT Version :9

Sequence 1:	NP_523750.2	Gene:	scb / 36692	FlyBaseID:	FBgn0286785	Length:	1115	Species:	Drosophila melanogaster
Sequence 2:	XP_021322596.1	Gene:	itga8 / 100141346	ZFINID:	ZDB-GENE-080220-48	Length:	1059	Species:	Danio rerio

Alignment Length:	1162	Identity:	281/1162 - (24%)
Similarity:	456/1162 - (39%)	Gaps:	223/1162 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FLALLALISHIEAFNFMPRPSRVINSPKHLKFHINQTRSSYFGYTLVI-------RQTSIIVGAP 69
            |..:|:......|||.......|.|.|:          .|||||:|..       ...|::||||
Zfish    24 FFLMLSFFCEAAAFNLDLEKPTVYNGPE----------GSYFGYSLDFYHPTQDRNVMSVLVGAP 78

  Fly    70 RAQSTLESQRTINETGAIYRC---SLTNGVCSPYVLDSRGNVDAPYSEYTFDSERKDFQWLGGSM 131
            :|.:   ||..|.|.||:|.|   :.....|.....|...|.....:......|.|..||.|.::
Zfish    79 KANT---SQPGIVEGGAVYYCPWPASDPDSCRQIPFDKANNRMIKVNGTREPLEFKSHQWFGATV 140

  Fly   132 DGGTKDTDKLLVCAP----RFYAPSSRDNHLHGVCYWVNNTVASTPQHVTRISPLRLKSEQVKEE 192
               .....|::.|||    |....||..:.: |.||......::..::    ||.|..:..  .|
Zfish   141 ---RTHKGKVVACAPLYQWRTVKVSSEMDPV-GTCYVAVQNFSAYAEY----SPCRTNNPD--PE 195

  Fly   193 DNGNKASFFYIMGELGLSAHVADDNTKFLIGAPGINTWRGSVILYRQVDPVDNPTASRRD--TSK 255
            ..|        ..:.|.|.....:.| .::|.||...|:|.||           ||...:  ...
Zfish   196 GQG--------FCQAGFSVDFTKEGT-LVVGGPGSFYWQGQVI-----------TAGVAEILNGY 240

  Fly   256 ALRRTYRDVDSNDYT---PEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYVATAPQ 317
            :|:...|.|.....|   .:.|             :|||.||:|:.|.|...:..:|  ||..|:
Zfish   241 SLKTILRKVQGEKQTVAASDTY-------------DDSYLGYSVAVGEFTGDSEQEL--VAGVPR 290

  Fly   318 ANKQSGEAYIFDVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHALED---- 378
            .....|  |:..:...::.....|.|||...||||::...||||||..||:|.||.:...:
Zfish   291 GAHNFG--YVTVINATNLTFIQNFTGEQMASYFGYTIAVTDLNGDGLDDVLVGAPLYMDREFESK 353

  Fly   379 SHDNGAIYVFINKGFFNFERQILRSPVETMARFGTALSRLGDINHDGYNDVAVGAPFAG---NGT 440
            ..:.|.:|:::.:....|...|..:.:....|:|:|::.|||||.|||.|||:||||||   .|.
Zfish   354 PREVGRVYLYLQEDVLLFSPPITLTGMHLFGRYGSAIAPLGDINQDGYLDVAIGAPFAGEDRGGR 418

  Fly   441 VFIYLGSENGLRDQPSQRLD---APSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAEAV 502
            ||||.|.::||..|.||.|.   |.|..|:.     ||..|...||:|.|.:.|..:||.....|
Zfish   419 VFIYNGQKSGLMLQASQVLKGDWASSGIPAG-----FGFTLRGDSDLDNNQYPDLLVGAFGVSKV 478

  Fly   503 YLYRAYPVVKVHATVKSESREIKPEQEK------------VKITACYRLSTTSTDKLVQEQELAI 555
            ..||:.|||.|.|.:....|.:.||.:.            :.:..|.::|.......|   .|.:
Zfish   479 VAYRSRPVVTVDAQLILRPRILNPEDKSCRMPNSDIMVTCLSVNVCAKISGIGIPDYV---ALRM 540

  Fly   556 RIAMD--KQ---LKRVKFTQTQTNEISFKVNANFGEQ--CRDFETQVRYSE--KDIFTPIDLEMH 611
            .:.:|  ||   :|||.|..:..::.|.::....|::  |.::...:|...  :|..:||.:.::
Zfish   541 ELQLDWLKQRGAVKRVLFMDSHQHQRSQQLVLGQGDRQHCHNYSVYLRDEAEFRDKLSPISVTLN 605

  Fly   612 YELTKKVPDSEEFCETCAIVDPTEPKVSTQNIIFSTGCATD-VCTADLQLRSKDVSPTYILGSAD 675
            |.|.:..|.:.  .:...::|........:.......|..| :|..||:|.:|......|:|..:
Zfish   606 YSLDQSSPPAG--LQLRPVLDHYSKTFHHEQANILLDCGEDNMCIPDLKLSAKMDRTELIIGDDN 668

  Fly   676 TLRLNYEITNIGETAYLPQFNVTSTSRLAFAQVPG--------NC----KVVDAVMVCDLNRGRP 728
            .|.|.....|.||.||..:.:||......:..|..        ||    :....::||||  |.|
Zfish   669 LLMLTINAANEGEGAYEAELHVTLPPEADYIGVERRREDLQRLNCEHRTENDTRIVVCDL--GNP 731

  Fly   729 LAKGDTDSVTISFDVSQLSGQSLIIHAEVFSTGYEQNPTDNRQTNV---IGLKEFTEIDASGGQT 790
            :......||.:.|.|::|......|..||  ..:..|..::|...|   :.:....|::..|...
Zfish   732 MVADTNLSVGLRFSVARLEDAPPTIGFEV--QIHSSNKDNSRSVPVNLTLSIVARAEVEIRGVSH 794

  Fly   791 NSQIDL------------EHYSNSAEIVNNYEIKSNGPSVIEQLTVSFYIPIAYKVAGSTAIIPI 843
            .:|:.|            .......::.:.||:.:.|||.|.:..:....|..|:.......:.:
Zfish   795 PAQVVLPFPRWEPKEKPVREDEVGPQVQHIYELHNKGPSSISRTVLEVGWPSRYREEHLLYALQV 859

  Fly   844 INVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEV-TTTLSGGLERTVITQNRQSYDIHTSGHV 907
            |  |...:..|.:|.|               :|:|: |:||....|.....:|
Zfish   860 I--TDGPVHCSTNSSL---------------NPLELETSTLQDTPELLGFLRN------------ 895

  Fly   908 HQTMEVLDTSMVATASMSRKRRDLKALTANREQYARISNVKAHDLLSDDFKGKLPVNRTIVFNCR 972
                         ::.::|:||.:....:...:....||:..  |:.:....:|...::.|...|
Zfish   896 -------------SSGVTRRRRSVSIGQSYNSKTLNCSNINC--LMVECVVDRLDRGQSAVIKFR 945

  Fly   973 DPEMTICVRAEMRVHFRPEKSINLNMRYSVDLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSF 1037
            ..............|:              .||...:..|....|.:....|..|.|...|...:
Zfish   946 SRLWAYTFLQRRNDHY--------------TLNSTVSFQVTAMPYRIKAETLPRQSKSIGTFVVW 996

  Fly  1038 SINRRIEPNIISKHQETGLPIWIIIVSVIGGLLLLSAISYLLYKFGFFNRTK--KDE 1092
            :|     |::     ...:|:|:||::::.|||:|:.:|..::|.|||:|.:  ||:
Zfish   997 AI-----PDV-----SFAIPLWVIILAILLGLLVLAVLSLAMWKCGFFDRARPPKDD 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	21/61 (34%)
		FG-GAP	350..388	CDD:280083	16/41 (39%)
		Int_alpha	409..459	CDD:214549	31/52 (60%)
		Int_alpha	473..>515	CDD:214549	17/41 (41%)
		Integrin_alpha2	507..829	CDD:285619	78/370 (21%)
itga8	XP_021322596.1	Int_alpha	52..112	CDD:214549	21/62 (34%)
		Int_alpha	263..311	CDD:214549	14/51 (27%)
		Int_alpha	317..>367	CDD:214549	17/49 (35%)
		Int_alpha	383..437	CDD:214549	31/53 (58%)
		Int_alpha	450..492	CDD:214549	17/41 (41%)
		Integrin_alpha2	483..924	CDD:312071	97/491 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574932
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740