DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8079 and SQS1

DIOPT Version :9

Sequence 1:	NP_611023.1	Gene:	CG8079 / 36689	FlyBaseID:	FBgn0034002	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_014175.1	Gene:	SQS1 / 855497	SGDID:	S000005168	Length:	767	Species:	Saccharomyces cerevisiae

Alignment Length:	808	Identity:	139/808 - (17%)
Similarity:	238/808 - (29%)	Gaps:	338/808 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLPAEEEDLADTVAKYDS----IELKSIQDL---ETCEQQQLLQYVEKLHGII--RKYDTKL--- 54
            |:|..|.||.|..|.::.    |..|:|:|.   ...:.:.:     |:.|:.  .:||:..
Yeast    51 SIPLGEGDLDDVGADFNPGRAFISPKTIEDYYFGRDAKSRSM-----KMGGLRPGNRYDSSTDLQ 110

  Fly    55 ---ASYKQKLLHYVSREE--------------KVSCDKASQATESE----------LQECQY--- 89
               |:::::.:.:|..:|              |.....:.:..|.|          ..:.:|
Yeast   111 AGRAAFRKRPMQFVKAKEVYDPSHNMIQKLRAKNETKNSEEIVEREADVFEEPGKMTSDVEYINN 175

  Fly    90 -SMENDEDTNKKDQPNDLSAT---------DAFSFVDEMRQAAKHAENLNNFVYEH--------- 135
             ..||::|.::.....|.|.:         |.| ||||..|.:.....:.....|.
Yeast   176 EDSENEDDDSQNSPSTDHSLSSNESKVEDGDLF-FVDEEAQQSPDLTKIKRVCIEEIARPREVAI 239

  Fly   136 ------TSGMY------------------------YDPKTGYYYNAEYGLYYDGNNGCYYSYD-- 168
                  |.|..                        |.|..||..|..:|::...::.....|:
Yeast   240 EFDPILTIGKVELSVSEGNESKEISVDVPNKGNKTYHPFAGYISNVLHGMHTSDSDNDELDYEIE 304

  Fly   169 ---HAKDSYEFHSQAQV------------------------------------------QANDAA 188
               :::..||..:.::|                                          :.|:..
Yeast   305 TENNSEPLYESSASSEVDQGFNYVGQRHNSRADNNLLPSPSPQLTEDIKCLSINGTKTFEGNNDN 369

  Fly   189 KPESEDEDLEVQFDE----------------LGGV------------------------ITD--- 210
            .|....|:||..|.|                :|||                        :||
Yeast   370 LPSPASEELEFGFKEEDFVINTNDIVVSNIRMGGVDNSYYLRCYRLLGDYDFHWIDQDLLTDFVV 434

  Fly   211 ------------------HETLKKIKAEK--------QKAKDQAEKSKRKAKKKK---------- 239
                              :..:.||:..:        ..:.|:.:..:..:.:..
Yeast   435 DELGLPEDRLPAYLNFIKNSLIPKIEPAEPTYSDIPISDSSDEGDSYEGDSYEDDEDMASSVVHS 499

  Fly   240 ------------SKKHSKKRSKK------ERRHKSKKRHRHSDDERSNDAEEGELSQSSDSSSDS 286
                        :.||..:|.|.      |.:.|.||:....||..:.|.|..|..||..|....
Yeast   500 DIEEGLDDLIAYTLKHDTERFKTFETKSLETKGKGKKKKLLIDDALALDTETLETLQSKFSKRIE 564

  Fly   287 SNEDSSSNTEDSSVPVFKAAGRFQDIAKKYPPSLRIIVQETNVESLKVGSLHLITYKGGSLGREG 351
            :........||.   :.:......|:.||||..|.|
Yeast   565 TKAKKRKAKEDF---IDQENRNSNDMLKKYPYGLHI----------------------------- 597

  Fly   352 AHDVIIPDVNVSKCHLKFKYENKLGIYQCLDLGSRNGTILNGSPMSSDAMDLVHGSVITLGQTRL 416
                         .::|.::|:.|         |||...|...|:..      ||:...:   ::
Yeast   598 -------------QNIKDEFESFL---------SRNNDRLTFPPLDP------HGNKTVM---KI 631

  Fly   417 LCHVHEGNSTCGLCEPGLLIENSPPVVAAVASSTASVLSHKEQLKKLQRKYGLENEKFVDTSGNG 481
            ..|.:..:|..|                 .|:.|:.|:   |::||  .|:...|...:|.....
Yeast   632 AKHYNMKSSKIG-----------------KANHTSVVV---EKIKK--TKWSSPNYSLIDQLMRQ 674

  Fly   482 QSNY---------NDRAATRRVQV--GSSTDKEKTEVACVNTEIGSSNKGFKMLSKLGWQKGEKL 535
            :..:         .::||..|.:.  |....||...|.....|||:.|.|.:||.||||:.||.|
Yeast   675 RPVFMRIDIRRPREEQAAFERTKTIRGKFHVKEGEIVGQNAPEIGNENIGRRMLEKLGWKSGEGL 739

  Fly   536 GKTNASAGLLEPINVVANEGTSGLGNSD 563
            | ...:.|:.|||.....:..|||.:|:
Yeast   740 G-IQGNKGISEPIFAKIKKNRSGLRHSE 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8079	NP_611023.1	OCRE_VG5Q	124..177	CDD:293883	12/96 (13%)
		OCRE repeat 1	129..136	CDD:293883	1/21 (5%)
		OCRE repeat 2	137..144	CDD:293883	2/30 (7%)
		OCRE repeat 3	145..152	CDD:293883	3/6 (50%)
		OCRE repeat 4	153..159	CDD:293883	1/5 (20%)
		OCRE repeat 5	162..169	CDD:293883	1/11 (9%)
		FHA	346..411	CDD:278899	10/64 (16%)
		G-patch	516..560	CDD:279867	18/43 (42%)
SQS1	NP_014175.1	R3H_G-patch	597..654	CDD:100075	17/136 (13%)
SQS1	NP_014175.1	G-patch	721..764	CDD:396249	19/43 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4438
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930