DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8079 and Gpatch2

DIOPT Version :9

Sequence 1:	NP_611023.1	Gene:	CG8079 / 36689	FlyBaseID:	FBgn0034002	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_080643.4	Gene:	Gpatch2 / 67769	MGIID:	1915019	Length:	527	Species:	Mus musculus

Alignment Length:	542	Identity:	114/542 - (21%)
Similarity:	177/542 - (32%)	Gaps:	159/542 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 SQATESELQECQYSMENDEDTNKKDQPNDLSATDAFSFVDEMRQAAKH-AENLNNFVYEHTSGMY 140
            |:.::|.|:|...........||||:    |.:|     |:|..|.:. :.||::.|
Mouse    88 SEGSDSSLEEPSKDYREKHSNNKKDR----SDSD-----DQMLVAKRRPSSNLSSSV-------- 135

  Fly   141 YDPKTGYYYNAEYGLYYDGNNGCYYSYDHAKDSYEFHS---------------------QAQVQA 184
                             .|....::..|.|.||....:                     :...|.
Mouse   136 -----------------RGKRLLWHESDFAVDSLGNRTLRRRRKVKRMAVDLPQDVSSKRTMTQL 183

  Fly   185 NDAAKPESEDEDLEVQFDELGGVITDHETLKKIKAEKQKAKDQAEKSKRKAKKKKSKKHSKKRSK 249
            .:..:.:..|.|...|:.|.        |.||:|..|.|......|::.:....:|
Mouse   184 PEGCRDQDMDNDRASQYPEF--------TRKKVKKRKLKGIRPGPKTQEEGGVLES--------- 231

  Fly   250 KERRHKSKKRHRHSDDERSNDAEEGELSQSSDSSSDSSNE------DSSSNTEDSSVPVF--KAA 306
            :||...:|.|..:.:.:.|:     ||...||:||.||.:      |.....:|.....|  |.:
Mouse   232 EERSQPNKDRMEYEEQKASD-----ELRSESDTSSLSSTDAGLFTNDEGRQGDDEQSDWFYEKES 291

  Fly   307 GRFQDIA-------KKYPPSLRIIVQETNVESLKVGSLHLITY--KGGSLGR-EGAHDVIIPDVN 361
            |....||       |..|..|...:.:...||:..||..|:::  :||...| ...|..  |..|
Mouse   292 GGACGIAGVVPWWEKDEPAELDTNLPDPVFESILSGSFPLMSHPGRGGFQARLSRLHGT--PSKN 354

  Fly   362 VSKCHLKFKYENKLGIYQCLDLGSRNGTILNGSPMSSDAMDLVHGSVITLGQTRLLCHVHEGNST 426
            :.|                 ..|:....:....|.|:..|  ||.|..        .|.|:
Mouse   355 IKK-----------------SSGAPPSMLSAPGPGSNKRM--VHFSPD--------AHRHD---- 388

  Fly   427 CGLCEPGLLIENSPPVVAAVASSTASVLSHKE--QLKKLQRKYGLENEKFVDTSGNGQSNYNDRA 489
             ....||...|:..   ..:.....:...||:  .||...|:..:.    :.:...|......:|
Mouse   389 -HWFSPGARTEHGQ---HQLLRDNRAERGHKKSCSLKTASRQTSMH----LGSLCTGDIKRRRKA 445

  Fly   490 A-----TRRVQVGSSTDKEKTEVACVNTEIGSSNKGFKMLSKLGWQKGEKLGKTNASAGLLEPIN 549
            |     |....||.:..           .|..||.|.:||..:||..|..||:.  ..|:.||:.
Mouse   446 APLPGPTAAGIVGENAQ-----------PILESNIGNRMLQSMGWTPGSGLGRD--GRGIAEPVQ 497

  Fly   550 VVANEGTSGLGNSDPVLSSSRT 571
            .|  :...|||...|:..||.|
Mouse   498 AV--QRPKGLGLGFPLPKSSPT 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8079	NP_611023.1	OCRE_VG5Q	124..177	CDD:293883	8/53 (15%)
		OCRE repeat 1	129..136	CDD:293883	1/6 (17%)
		OCRE repeat 2	137..144	CDD:293883	0/6 (0%)
		OCRE repeat 3	145..152	CDD:293883	0/6 (0%)
		OCRE repeat 4	153..159	CDD:293883	0/5 (0%)
		OCRE repeat 5	162..169	CDD:293883	0/6 (0%)
		FHA	346..411	CDD:278899	12/65 (18%)
		G-patch	516..560	CDD:279867	15/43 (35%)
Gpatch2	NP_080643.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..135		15/55 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	175..281		27/127 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..375		6/43 (14%)
		G-patch	467..510	CDD:279867	17/46 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..527		14/42 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4438
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840