DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8079 and Aggf1

DIOPT Version :9

Sequence 1:	NP_611023.1	Gene:	CG8079 / 36689	FlyBaseID:	FBgn0034002	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_079906.2	Gene:	Aggf1 / 66549	MGIID:	1913799	Length:	711	Species:	Mus musculus

Alignment Length:	710	Identity:	203/710 - (28%)
Similarity:	313/710 - (44%)	Gaps:	152/710 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PAE-EEDLADTVAKYDSIELKSIQDLETCEQQ-----QLLQYVEKLHGIIRKYDTKLASYKQ--- 59
            ||. |.:||....|.:.:|    ::|.:|.:|     :|||:.|:|:......:.:|.:..:
Mouse    16 PASPEPELAQLRRKVEKLE----RELRSCRRQVREVEKLLQHTERLYRNAESDNQELRTQVEELS 76

  Fly    60 KLLHYVSREEKVSCDKASQATESE---------LQECQYSMENDEDTNKKD-------------- 101
            |:||....|:....|...| |||:         .|.|.    ||:....|:
Mouse    77 KILHCGKNEDNPKSDVEVQ-TESQAPWAISDYYYQTCY----NDDSLPSKETELCVQQSQCAQAS 136

  Fly   102 --QPNDLSATDAFSF---------------------------------------VDEMRQAAKHA 125
              .|.|.|..|:.|:                                       .:.:|.||:.|
Mouse   137 ALDPQDESHIDSGSYAGADATEGVSHRQEDAVTSDSQESVSALAEGPALEGSSLAESLRAAAEAA 201

  Fly   126 ENLNNFVYEHTSGMYYDPKTGYYYNAEYGLYYDGNNGCYYSYDHAKDSYEFHSQAQVQ--ANDAA 188
            .:...|.|:.::|:|:|..||:||::|..||||.:.|.||..|.....|:|||:..:|  ...:.
Mouse   202 VSQTGFTYDESTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFHSRVDLQPYQTSST 266

  Fly   189 KPESEDEDLEVQFDELGGVITDHETLKKIKAEKQKA----------KDQAEKSKRKAKKKKSKKH 243
            ||..| ..|:.:..|.|....:.|  |.:.:|.||.          .:.:...|:||:...|.|.
Mouse   267 KPNRE-RRLKKRRKEPGFYTANEE--KDLSSEDQKVCSVEYINCSEDEHSGNVKKKARTDTSHKS 328

  Fly   244 SKKR-----------SKKERRHKSKKRHRHSDDERSNDAEEGELSQSS-----DSSSDSSNEDSS 292
            |..:           |..:....|.|..|..:.|  ::.||||::.|.     |..|.|.:.::|
Mouse   329 SPLQLTVAVSGDTVESPGDDNSASSKDERIGESE--SEPEEGEITDSQSEKSYDGDSSSGDRETS 391

  Fly   293 SNTEDSSVPVFKAAGRFQDIAKKYPPSLRIIVQETNVESLKVGSLHLIT-YKGGSLGREG--AHD 354
            ..::|            :|..:.:||.:|:||..:.|  |::|||.:|| ....::|||.  .|.
Mouse   392 EESDD------------EDEERIWPPCIRVIVIRSPV--LQMGSLFIITAVSPATIGREKDMEHT 442

  Fly   355 VIIPDVNVSKCHLKFKYENKLGIYQCLDLGSRNGTILNGSPM-----SSDAMDLVHGSVITLGQT 414
            |.||:|.|||.|.:..:::.|..|..:|.||:||||:||..:     ..|...|.||..:.:|:|
Mouse   443 VRIPEVAVSKFHAEVYFDHDLQSYVLVDQGSQNGTIVNGKQILQPKTKCDPYVLEHGDEVKIGET 507

  Fly   415 RLLCHVHEGNSTCGLCEPG------LLIENSPPVVAAVASSTASVLSHKEQLKKLQRKYGLENEK 473
            .|..|:|.|:.||..||||      .|.....|:|....|.....|..::.|||::.||||:|..
Mouse   508 VLSFHIHPGSETCDGCEPGQVRAHLRLDRKDEPLVGPALSKEEKELERRKALKKIRVKYGLQNTD 572

  Fly   474 FVDTSGNGQSNYNDRAATRRVQVGSSTDKEKTEV-ACVNTEIGSSNKGFKMLSKLGWQKGEKLGK 537
            :..........|.|||..||.||||....::.:. |.|::||..||||.|||.|:||::||.|||
Mouse   573 YEAEKALKNPKYKDRAGKRREQVGSEGTFQRDDAPASVHSEITDSNKGRKMLEKMGWKRGEGLGK 637

  Fly   538 TNASAGLLEPINVVANEGTSGLGNSDPVLSSSRTIDKRKLANLKITQARYQRASDMFGQS 597
            .  ..|:..||.:......:|||...  |||   ||...|...| ::..:.:|.:.|.::
Mouse   638 D--GGGMKTPIQLQLRRTHAGLGTGK--LSS---IDDVHLIQNK-SKKHWDKARERFAET 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8079	NP_611023.1	OCRE_VG5Q	124..177	CDD:293883	20/52 (38%)
		OCRE repeat 1	129..136	CDD:293883	2/6 (33%)
		OCRE repeat 2	137..144	CDD:293883	3/6 (50%)
		OCRE repeat 3	145..152	CDD:293883	4/6 (67%)
		OCRE repeat 4	153..159	CDD:293883	3/5 (60%)
		OCRE repeat 5	162..169	CDD:293883	3/6 (50%)
		FHA	346..411	CDD:278899	27/71 (38%)
		G-patch	516..560	CDD:279867	19/43 (44%)
Aggf1	NP_079906.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..184		5/46 (11%)
		OCRE_VG5Q	200..253	CDD:293883	20/52 (38%)
		OCRE repeat 1	205..212	CDD:293883	2/6 (33%)
		OCRE repeat 2	213..220	CDD:293883	3/6 (50%)
		OCRE repeat 3	221..228	CDD:293883	4/6 (67%)
		OCRE repeat 4	229..235	CDD:293883	3/5 (60%)
		OCRE repeat 5	238..245	CDD:293883	3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..297		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..400		22/102 (22%)
		FHA	407..513	CDD:238017	40/107 (37%)
		FHA	<424..509	CDD:224630	31/84 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..623		18/43 (42%)
		G-patch	617..658	CDD:279867	19/42 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	690..711		203/710 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842754
Domainoid	1	1.000	62	1.000	Domainoid score	I10340
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3520
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006982
OrthoInspector	1	1.000	-	-		oto94888
orthoMCL	1	0.900	-	-		OOG6_106578
Panther	1	1.100	-	-	LDO	PTHR23106
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4438
SonicParanoid	1	1.000	-	-		X5069
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780