DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8079 and AGGF1

DIOPT Version :9

Sequence 1:	NP_611023.1	Gene:	CG8079 / 36689	FlyBaseID:	FBgn0034002	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_060516.2	Gene:	AGGF1 / 55109	HGNCID:	24684	Length:	714	Species:	Homo sapiens

Alignment Length:	705	Identity:	195/705 - (27%)
Similarity:	315/705 - (44%)	Gaps:	133/705 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EEDLADTVAKYDSIELKSIQDLETCEQQ-----QLLQYVEKLHGIIRKYDTKLASYKQKLLHYVS 66
            |.:||....|.:.:|    ::|.:|::|     :||.:.|:|:......:.:|.:..::|...:.
Human    19 EPELAQLRRKVEKLE----RELRSCKRQVREIEKLLHHTERLYQNAESNNQELRTQVEELSKILQ 79

  Fly    67 R---EEKVSCD-----------------------------KASQATESELQECQYSMENDED--- 96
            |   |:....|                             |.::.::.:.|..:.|:.|.:|
Human    80 RGRNEDNKKSDVEVQTENHAPWSISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQ 144

  Fly    97 ------------------------TNKKDQPNDLSATD----AFSFVDEMRQAAKHAENLNNFVY 133
                                    :|.::..:.|:..|    ..|..:.:|.||:.|.:...|.|
Human   145 VENDAYPGTDRTENVKYRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSY 209

  Fly   134 EHTSGMYYDPKTGYYYNAEYGLYYDGNNGCYYSYDHAKDSYEFHSQAQVQA-NDAAKPESEDEDL 197
            :..:|:|:|..||:||::|..||||.:.|.||..|.....|:|||:..:|. ..::..:|:|:.|
Human   210 DENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKL 274

  Fly   198 EVQFDELGGVITDHETLKKIKAEKQKA-------KDQAEKSKRKAKKKKSKKHSKKRSKK----- 250
            :.:..:.....|:.|  |.:.:|.|||       .::.|......||.|...|.|....|
Human   275 KKKRKDPDSSATNEE--KDLNSEDQKAFSVEHTSCNEEENFANMKKKAKIGIHHKNSPPKVTVPT 337

  Fly   251 ------ERRHKSKKRHRHSDDER----SNDAEEGEL--SQSSDSSSDSSNEDSSSNTEDSSVPVF 303
                  ...|::........||:    .::.||||:  ||:.||..::...:.:...|||
Human   338 SGNTIESPLHENISNSTSFKDEKIMETDSEPEEGEITDSQTEDSYDEAITSEGNVTAEDS----- 397

  Fly   304 KAAGRFQDIAKKYPPSLRIIVQETNVESLKVGSLHLIT-YKGGSLGREG--AHDVIIPDVNVSKC 365
                ..:|..|.:||.:|:||..:.|  |::|||.:|| ....::|||.  .|.:.||:|.|||.
Human   398 ----EDEDEDKIWPPCIRVIVIRSPV--LQIGSLFIITAVNPATIGREKDMEHTLRIPEVGVSKF 456

  Fly   366 HLKFKYENKLGIYQCLDLGSRNGTILNGSPM-----SSDAMDLVHGSVITLGQTRLLCHVHEGNS 425
            |.:..:::.|..|..:|.||:||||:||..:     ..|...|.||..:.:|:|.|..|:|.|:.
Human   457 HAEIYFDHDLQSYVLVDQGSQNGTIVNGKQILQPKTKCDPYVLEHGDEVKIGETVLSFHIHPGSD 521

  Fly   426 TCGLCEPG------LLIENSPPVVAAVASSTASVLSHKEQLKKLQRKYGLENEKFVDTSGNGQSN 484
            ||..||||      .|.:.....|....|.....|..:::|||::.||||:|.::.|........
Human   522 TCDGCEPGQVRAHLRLDKKDESFVGPTLSKEEKELERRKELKKIRVKYGLQNTEYEDEKTLKNPK 586

  Fly   485 YNDRAATRRVQVGSSTDKEKTEV-ACVNTEIGSSNKGFKMLSKLGWQKGEKLGKTNASAGLLEPI 548
            |.|||..||.||||....::.:. |.|::||..||||.|||.|:||:|||.|||.  ..|:..||
Human   587 YKDRAGKRREQVGSEGTFQRDDAPASVHSEITDSNKGRKMLEKMGWKKGEGLGKD--GGGMKTPI 649

  Fly   549 NVVANEGTSGLGNSDPVLSSSRTIDKRKLANLKITQARYQRASDMF----GQSDD 599
            .:......:|||...|  ||...:...:..|.|......:|.::.|    .|.||
Human   650 QLQLRRTHAGLGTGKP--SSFEDVHLLQNKNKKNWDKARERFTENFPETKPQKDD 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8079	NP_611023.1	OCRE_VG5Q	124..177	CDD:293883	20/52 (38%)
		OCRE repeat 1	129..136	CDD:293883	2/6 (33%)
		OCRE repeat 2	137..144	CDD:293883	3/6 (50%)
		OCRE repeat 3	145..152	CDD:293883	4/6 (67%)
		OCRE repeat 4	153..159	CDD:293883	3/5 (60%)
		OCRE repeat 5	162..169	CDD:293883	3/6 (50%)
		FHA	346..411	CDD:278899	26/71 (37%)
		G-patch	516..560	CDD:279867	20/43 (47%)
AGGF1	NP_060516.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		1/2 (50%)
		OCRE_VG5Q	200..253	CDD:293883	20/52 (38%)
		OCRE repeat 1	205..212	CDD:293883	2/6 (33%)
		OCRE repeat 2	213..220	CDD:293883	3/6 (50%)
		OCRE repeat 3	221..228	CDD:293883	4/6 (67%)
		OCRE repeat 4	229..235	CDD:293883	3/5 (60%)
		OCRE repeat 5	238..245	CDD:293883	3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..307		11/49 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..384		14/61 (23%)
		FHA	410..516	CDD:238017	39/107 (36%)
		FHA	<422..512	CDD:224630	33/89 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	586..617		12/30 (40%)
		G-patch	620..661	CDD:295392	20/42 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..714		13/50 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152699
Domainoid	1	1.000	63	1.000	Domainoid score	I10278
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I3471
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D334272at33208
OrthoFinder	1	1.000	-	-		FOG0006982
OrthoInspector	1	1.000	-	-		oto91310
orthoMCL	1	0.900	-	-		OOG6_106578
Panther	1	1.100	-	-	LDO	PTHR23106
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4438
SonicParanoid	1	1.000	-	-		X5069
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790