DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8079 and Rbm10

DIOPT Version :9

Sequence 1:	NP_611023.1	Gene:	CG8079 / 36689	FlyBaseID:	FBgn0034002	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_663602.1	Gene:	Rbm10 / 236732	MGIID:	2384310	Length:	930	Species:	Mus musculus

Alignment Length:	476	Identity:	96/476 - (20%)
Similarity:	149/476 - (31%)	Gaps:	185/476 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 NLNNFVYEHTSGMYYDPKTGYYYNAEYGLYYDGNNGCYYSYDHAKDSY--EFHSQAQVQANDAAK 189
            :::.:.|:.|||.||||:||.||:.....||:..:..|..:|..:.:|  .....|....:..|.
Mouse   568 DVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNAQSQQYLYWDGERRTYIPALEQSADGHKDTGAS 632

  Fly   190 PESEDEDLEVQFDELGGVITDHETLKKIKAEKQKAKDQAEKSKRKAKKKKSKKHS---------- 244
            .:...|..|           .|:|    |..:|.|||....::...|:|::.|:|
Mouse   633 SKEGKEKKE-----------KHKT----KTAQQIAKDMERWARSLNKQKENFKNSFQPISALRDD 682

  Fly   245 ----------------KKRSKKERRHKSKKRHRHSDDERSNDAEEGELSQSSDSSSDSSNEDSSS 293
                            ||.:..||:|.|....:.:.|:|.:.......:.|.:|.|:...|
Mouse   683 ERRESATADAGYAILEKKGALAERQHTSMDLPKLASDDRPSPPRGLVAAYSGESDSEEEQE---- 743

  Fly   294 NTEDSSVPVFKAAGRFQDIAKKYPPSLRIIVQETNVESLKVGSLHLITYKGGSLGREGAHDVIIP 358
                                                             :||.
Mouse   744 -------------------------------------------------RGGP------------ 747

  Fly   359 DVNVSKCHLKFKYENKLGIYQCLDLGSRNGTILNGSPMSSDAMDLVHGSVITLGQTRLLCHVHEG 423
                       :.|.||..:|.|
Mouse   748 -----------EREEKLTDWQKL------------------------------------------ 759

  Fly   424 NSTCGLCEPGLLIENSPPVVAAVASSTASVLSHKEQLKKLQRKYGLENE-KFVDTSGNGQSNYND 487
              .|.||.     ...|...|.:.....|.| ||:.|:..:|.:..||| :.::.:...|..|.|
Mouse   760 --ACLLCR-----RQFPSKEALIRHQQLSGL-HKQNLEIHRRAHLSENELEALEKNDMEQMKYRD 816

  Fly   488 RAATRRVQVGSSTDKEK-------TEVACVNTE------IGSSNKGFKMLSKLGWQKGEKLGKTN 539
            |||.||.:.|.....|.       ...|.|:.|      :||.|.|.:||..:||::|..||:
Mouse   817 RAAERREKYGIPEPPEPKRRKYGGISTASVDFEQPTRDGLGSDNIGSRMLQAMGWKEGSGLGR-- 879

  Fly   540 ASAGLLEPINVVANEGTSGLG 560
            ...|::.||........||||
Mouse   880 KKQGIVTPIEAQTRVRGSGLG 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8079	NP_611023.1	OCRE_VG5Q	124..177	CDD:293883	17/51 (33%)
		OCRE repeat 1	129..136	CDD:293883	1/6 (17%)
		OCRE repeat 2	137..144	CDD:293883	5/6 (83%)
		OCRE repeat 3	145..152	CDD:293883	4/6 (67%)
		OCRE repeat 4	153..159	CDD:293883	2/5 (40%)
		OCRE repeat 5	162..169	CDD:293883	1/6 (17%)
		FHA	346..411	CDD:278899	5/64 (8%)
		G-patch	516..560	CDD:279867	15/43 (35%)
Rbm10	NP_663602.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..127
		RRM	21..>232	CDD:223796
		RRM1_RBM10	127..211	CDD:241197
		ELAV_HUD_SF	136..381	CDD:273741
		ZnF_RBZ	215..239	CDD:197784
		RanBP2-type Zn finger	217..236	CDD:275375
		RRM2_RBM10	298..384	CDD:241198
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..487
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..522
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..566
		OCRE_RBM10	564..627	CDD:293886	18/58 (31%)
		OCRE repeat 1	570..577	CDD:293886	1/6 (17%)
		OCRE repeat 2	578..585	CDD:293886	5/6 (83%)
		OCRE repeat 3	586..593	CDD:293886	4/6 (67%)
		OCRE repeat 4	594..601	CDD:293886	2/6 (33%)
		OCRE repeat 5	603..610	CDD:293886	1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	620..646		6/40 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..753		9/116 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..861		11/42 (26%)
		G-patch	858..902	CDD:279867	17/45 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900