DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8079 and RBM5

DIOPT Version :9

Sequence 1:	NP_611023.1	Gene:	CG8079 / 36689	FlyBaseID:	FBgn0034002	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_005769.1	Gene:	RBM5 / 10181	HGNCID:	9902	Length:	815	Species:	Homo sapiens

Alignment Length:	691	Identity:	136/691 - (19%)
Similarity:	214/691 - (30%)	Gaps:	272/691 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IELKSIQDLETCEQQQLLQYVEKLHGIIRKYDTK-----LASYKQKLLHYVSREEKVSC-DKASQ 78
            ::|.|..|     ..||||.::.||..: |.|.|     .|...:|.| .:|...:||. ..||.
Human   279 VQLSSAMD-----ASQLLQILQSLHPPL-KIDGKTIGVDFAKSARKDL-VLSDGNRVSAFSVAST 336

  Fly    79 A--------TESE-------------------LQECQYS-------------MENDEDT------ 97
            |        |:|:                   .|..|||             :|:|..:
Human   337 AIAAAQWSSTQSQSGEGGSVDYSYLQPGQDGYAQYAQYSQDYQQFYQQQAGGLESDASSASGTAV 401

  Fly    98 ---------------NKKDQPNDLSATDAFSFVDEMRQA-----------AKHA-ENLNNFVYEH 135
                           |:...|......:|........||           .|:| .:.:.:.|:.
Human   402 TTTSAAVVSQSPQLYNQTSNPPGSPTEEAQPSTSTSTQAPAASPTGVVPGTKYAVPDTSTYQYDE 466

  Fly   136 TSGMYYDPKTGYYYNAEYGLYYDGNNGCYYSYDHAKDSYEFHSQAQVQANDAAKPESEDEDLEVQ 200
            :||.||||.||.||:.....||:.....|..:|..|::|...:::.........|..|.::.:.:
Human   467 SSGYYYDPTTGLYYDPNSQYYYNSLTQQYLYWDGEKETYVPAAESSSHQQSGLPPAKEGKEKKEK 531

  Fly   201 FDELGGVITDHETLKKIKAEKQKAKDQAEKSKRKAKKKKSKKHS--------------------- 244
                          .|.|..:|.|||....:|...|:|::.|:|
Human   532 --------------PKSKTAQQIAKDMERWAKSLNKQKENFKNSFQPVNSLREEERRESAAADAG 582

  Fly   245 -----KKRSKKERRHKSKKRHRHSDDERSNDAEEGELSQSSDSSSDSSNEDSSSNTEDSSVPVFK 304
                 ||.:..||:....:..|:.|:|  |..:.|.::.   .|.||.||
Human   583 FALFEKKGALAERQQLIPELVRNGDEE--NPLKRGLVAA---YSGDSDNE--------------- 627

  Fly   305 AAGRFQDIAKKYPPSLRIIVQETNVESLKVGSLHLITYKGGSLGREGAHDVIIPDVNVSKCHLKF 369
                                 |..||.|:.....|..:|               .:....|..:|
Human   628 ---------------------EELVERLESEEEKLADWK---------------KMACLLCRRQF 656

  Fly   370 KYENKLGIYQCL-DLGSRNGTILNGSPMSSDAMDLVHGSVITLGQTRLLCHVHEGNSTCGLCEPG 433
            ..::.|..:|.| ||..:|..|...|.:|...::.:
Human   657 PNKDALVRHQQLSDLHKQNMDIYRRSRLSEQELEAL----------------------------- 692

  Fly   434 LLIENSPPVVAAVASSTASVLSHKEQLKKLQRKYGLENEKFVDTSGNGQSNYNDRAATRRVQVG- 497
                                     :|::.:.|                  |.||||.||.:.|
Human   693 -------------------------ELREREMK------------------YRDRAAERREKYGI 714

  Fly   498 ----SSTDKEKTEVACVNTE------IGSSNKGFKMLSKLGWQKGEKLGKTNASAGLLEPINVVA 552
                ....|::.:...||.|      |..||.|.|||..:||::|..||:  ...|:..||....
Human   715 PEPPEPKRKKQFDAGTVNYEQPTKDGIDHSNIGNKMLQAMGWREGSGLGR--KCQGITAPIEAQV 777

  Fly   553 NEGTSGLGNSDPVLSSSRTIDKRKLANLKITQARYQRASDM 593
            ....:|||........|.. |..|.|   :.:|.:.|.::|
Human   778 RLKGAGLGAKGSAYGLSGA-DSYKDA---VRKAMFARFTEM 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8079	NP_611023.1	OCRE_VG5Q	124..177	CDD:293883	18/53 (34%)
		OCRE repeat 1	129..136	CDD:293883	1/6 (17%)
		OCRE repeat 2	137..144	CDD:293883	5/6 (83%)
		OCRE repeat 3	145..152	CDD:293883	4/6 (67%)
		OCRE repeat 4	153..159	CDD:293883	2/5 (40%)
		OCRE repeat 5	162..169	CDD:293883	1/6 (17%)
		FHA	346..411	CDD:278899	11/65 (17%)
		G-patch	516..560	CDD:279867	15/43 (35%)
RBM5	NP_005769.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93
		RRM	40..>181	CDD:223796
		RRM1_RBM5	93..179	CDD:241196
		zf-RanBP	181..210	CDD:279035
		RanBP2-type Zn finger	185..204	CDD:275375
		RRM2_RBM5	229..314	CDD:241199	12/40 (30%)
		Required for interaction with U2AF2. /evidence=ECO:0000269\|PubMed:18851835	321..809		119/635 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..468		8/56 (14%)
		Sufficient for interaction with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200. /evidence=ECO:0000269\|PubMed:18851835	452..535		22/96 (23%)
		OCRE_RBM5	455..510	CDD:293887	18/54 (33%)
		OCRE repeat 1	460..467	CDD:293887	1/6 (17%)
		OCRE repeat 2	468..475	CDD:293887	5/6 (83%)
		OCRE repeat 3	476..483	CDD:293887	4/6 (67%)
		OCRE repeat 4	484..491	CDD:293887	2/6 (33%)
		OCRE repeat 5	493..500	CDD:293887	1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	507..540		4/46 (9%)
		G-patch	743..787	CDD:279867	17/45 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900