DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8079 and RBM6

DIOPT Version :9

Sequence 1:	NP_611023.1	Gene:	CG8079 / 36689	FlyBaseID:	FBgn0034002	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_005768.1	Gene:	RBM6 / 10180	HGNCID:	9903	Length:	1123	Species:	Homo sapiens

Alignment Length:	551	Identity:	101/551 - (18%)
Similarity:	151/551 - (27%)	Gaps:	265/551 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 DTNKKDQPNDLSATDAFSFVDEMRQAAKHAENLNNFVYEHTSGMYYDPKTGYYYNAEYGLYYDGN 160
            |||::.|.   |::|.:                           .||..|||||:...|.|||.|
Human   777 DTNRQGQQ---SSSDCY---------------------------IYDSATGYYYDPLAGTYYDPN 811

  Fly   161 NGCYYSYDHAKDSYEFHSQAQVQA-NDAAKPESEDEDLEVQFDELGGVITDHETLKKIKAEKQKA 224
                             :|.:|.. .|...||.|:                      ||
Human   812 -----------------TQQEVYVPQDPGLPEEEE----------------------IK------ 831

  Fly   225 KDQAEKSKRKAKKKKSKKHSKKRSKKERRHKSKKRHRHSDDERSNDAEE---------------- 273
                ||......|..|||...||..||::.:...|.:.:..|....||:
Human   832 ----EKKPTSQGKSSSKKEMSKRDGKEKKDRGVTRFQENASEGKAPAEDVFKKPLPPTVKKEESP 892

  Fly   274 -------------GELSQSSDSSSDSSNEDSSSNTEDSSVPVFKAAGRFQDIAKKYPPSLRIIVQ 325
                         ||....||...:...|.:.                        ||..|....
Human   893 PPPKVVNPLIGLLGEYGGDSDYEEEEEEEQTP------------------------PPQPRTAQP 933

  Fly   326 ETNVESLKVGSLHLITYKGGSLGREGAHDVIIPDVNVSKCHL-KFKYENK---LGIYQCLDLGSR 386
            :...|..|               :|...|. :.|.|...|.| :.::.||   :...|..||..:
Human   934 QKREEQTK---------------KENEEDK-LTDWNKLACLLCRRQFPNKEVLIKHQQLSDLHKQ 982

  Fly   387 NGTILNGSPMSSDAMDLVHGSVITLGQTRLLCHVHEGNSTCGLCEPGLLIENSPPVVAAVASSTA 451
            |                              ..:|.
Human   983 N------------------------------LEIHR----------------------------- 988

  Fly   452 SVLSHKEQLKKLQRKYGLENE-KFVDTSGNGQSNYNDR---------AATRRVQVGSSTDKEKTE 506
            .:...:::|..|:|:   |.| ||   .|.|    |||         ...:|::....||.::..
Human   989 KIKQSEQELAYLERR---EREGKF---KGRG----NDRREKLQSFDSPERKRIKYSRETDSDRKL 1043

  Fly   507 VACVNTEIGSSNKGFKMLSKLGWQKGEKLGKTNASAGLLEPINVVANEGTSGLGNSD-------- 563
            |.  ..:|.:|:||..:....||:||..||                 .|..||.:|:
Human  1044 VD--KEDIDTSSKGGCVQQATGWRKGTGLG-----------------YGHPGLASSEEAEGRMRG 1089

  Fly   564 PVLSSSRTIDKRKL------ANLKITQARYQ 588
            |.:.:|....||:.      |..::..|||:
Human  1090 PSVGASGRTSKRQSNETYRDAVRRVMFARYK 1120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8079	NP_611023.1	OCRE_VG5Q	124..177	CDD:293883	12/52 (23%)
		OCRE repeat 1	129..136	CDD:293883	0/6 (0%)
		OCRE repeat 2	137..144	CDD:293883	2/6 (33%)
		OCRE repeat 3	145..152	CDD:293883	5/6 (83%)
		OCRE repeat 4	153..159	CDD:293883	3/5 (60%)
		OCRE repeat 5	162..169	CDD:293883	0/6 (0%)
		FHA	346..411	CDD:278899	12/68 (18%)
		G-patch	516..560	CDD:279867	11/43 (26%)
RBM6	NP_005768.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..391
		YjbI	<92..237	CDD:224276
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..454
		RRM1_RBM6	456..533	CDD:240760
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..654
		RRM2_RBM6	654..740	CDD:241007
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..787		5/12 (42%)
		OCRE_RBM6	766..825	CDD:293882	21/94 (22%)
		OCRE repeat 1	772..779	CDD:293882	1/1 (100%)
		OCRE repeat 2	788..795	CDD:293882	3/33 (9%)
		OCRE repeat 3	796..803	CDD:293882	5/6 (83%)
		OCRE repeat 4	804..811	CDD:293882	4/6 (67%)
		OCRE repeat 5	814..821	CDD:293882	1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	827..948		28/191 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1004..1106		31/127 (24%)
		G_patch	1049..1095	CDD:197727	15/62 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0154
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900