DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8093 and LIPF

DIOPT Version :9

Sequence 1:	NP_001286441.1	Gene:	CG8093 / 36686	FlyBaseID:	FBgn0033999	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_001185758.1	Gene:	LIPF / 8513	HGNCID:	6622	Length:	408	Species:	Homo sapiens

Alignment Length:	401	Identity:	144/401 - (35%)
Similarity:	227/401 - (56%)	Gaps:	15/401 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LVVQLIAVFLSLGLANALPADTGRASSVTTVTI---VRGHGYEIEEHEVQTSDGYILTMHRIPY- 62
            |::.:.::...||..:.|.......|...|:.|   :...||..||:||.|.|||||.::||||
Human    13 LLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYG 77

  Fly    63 SKNTGYDGPRPVVFLMHGLLCSSSDWVLAGPHSGLAYLLSEAGYDVWMGNARGNTYSKRHASKSP 127
            .||:|..|.||||||.||||.|:::|:...|::.||::|::||||||:||:||||:::|:...||
Human    78 KKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRGNTWARRNLYYSP 142

  Fly   128 LLQPFWNFEWHDIGIYDLPAMMDYVLYWTNVTQLTYVGHSQGTTSFFVLNSMIPRFKSRIRSAHL 192
            ....||.|.:.::..|||||.:|:::..|...||.|||||||||..|:..|..|....||::.:.
Human   143 DSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYA 207

  Fly   193 LAPVAWMEHMESPLATVGGPLLGQPNA-FVELFGSAEFLPNTQLMNLFGALLCSDEAISQFMCTN 256
            |||||.:::.:|.:    ..|...|.: |..:||...|.|:..........:||.|.:: .:|:|
Human   208 LAPVATVKYTKSLI----NKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLN-LLCSN 267

  Fly   257 TLFLLGGWNSPYINETLLPDIMATTPAGCSVNQIFHYLQEYNSGYFRQFDYGS-TRNKKEYSSKT 320
            .||::.|::|...|.:.|...::..|||.||..:||:.|...||.|:.:|:|| .:|:..|....
Human   268 ALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQ 332

  Fly   321 PPEYDVEGIDVPTYLYYSDNDYFASLIDVDRLRYTMNPSALKSAYRMPEEKWNHIDFLWGLNIKE 385
            ||.|:|..::||..::....|..|...||..|.    |......|......:||:||:|.::..:
Human   333 PPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLL----PKLPNLIYHKEIPFYNHLDFIWAMDAPQ 393

  Fly   386 ILYDRVINDIN 396
            .:|:.:::.|:
Human   394 EVYNDIVSMIS 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8093	NP_001286441.1	PLN02872	9..392	CDD:215470	142/388 (37%)
		Abhydro_lipase	31..92	CDD:282003	34/64 (53%)
		Abhydrolase_5	74..>214	CDD:289465	61/139 (44%)
LIPF	NP_001185758.1	PLN02872	14..400	CDD:215470	142/394 (36%)
		Abhydro_lipase	45..107	CDD:282003	33/61 (54%)
		Abhydrolase_5	88..>211	CDD:289465	58/122 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141737
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8502
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1506
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840