DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8093 and Lipf

DIOPT Version :9

Sequence 1:	NP_001286441.1	Gene:	CG8093 / 36686	FlyBaseID:	FBgn0033999	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_080610.1	Gene:	Lipf / 67717	MGIID:	1914967	Length:	395	Species:	Mus musculus

Alignment Length:	398	Identity:	138/398 - (34%)
Similarity:	228/398 - (57%)	Gaps:	18/398 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLVVQLIAVFLSLGLANALPADTGRASSVTTVTI---VRGHGYEIEEHEVQTSDGYILTMHRIPY 62
            :||..:::.|   |.|:.|....|..:....:.:   :...||..||:||.|.|||||.::||||
Mouse     4 LLVTSVLSAF---GGAHGLFGKLGPKNPEANMNVSQMITYWGYPSEEYEVVTEDGYILGVYRIPY 65

  Fly    63 -SKNTGYDGPRPVVFLMHGLLCSSSDWVLAGPHSGLAYLLSEAGYDVWMGNARGNTYSKRHASKS 126
             .||:...|.|||.:|.|||:.|:::|:...|::.||::|::||||||:||:||||:|:::...|
Mouse    66 GKKNSENIGKRPVAYLQHGLIASATNWITNLPNNSLAFILADAGYDVWLGNSRGNTWSRKNVYYS 130

  Fly   127 PLLQPFWNFEWHDIGIYDLPAMMDYVLYWTNVTQLTYVGHSQGTTSFFVLNSMIPRFKSRIRSAH 191
            |....||.|.:.::..|||||.:|:::..|...::.|||||||||..|:..|..|....:|:..:
Mouse   131 PDSVEFWAFSFDEMAKYDLPATIDFIVQKTGQEKIHYVGHSQGTTIGFIAFSTNPALAKKIKRFY 195

  Fly   192 LLAPVAWMEHMESPLATVGGPLLGQPNAFVE-LFGSAEFLPNTQLMNLFGALLCSDEAISQFMCT 255
            .|||||.:::.|||...:.  |:  |...:: :||:..|:|:..|....|..:||.|.: ..:|:
Mouse   196 ALAPVATVKYTESPFKKIS--LI--PKFLLKVIFGNKMFMPHNYLDQFLGTEVCSRELL-DLLCS 255

  Fly   256 NTLFLLGGWNSPYINETLLPDIMATTPAGCSVNQIFHYLQEYNSGYFRQFDYGS-TRNKKEYSSK 319
            |.||:..|::...:|.:.....:...|||.|...:||:.|...||..:.:::|| .:|...|:.|
Mouse   256 NALFIFCGFDKKNLNVSRFDVYLGHNPAGTSTQDLFHWAQLAKSGKLQAYNWGSPLQNMLHYNQK 320

  Fly   320 TPPEYDVEGIDVPTYLYYSDNDYFASLIDVDRLRYTMNPSALKSAYRMPEEKWNHIDFLWGLNIK 384
            |||.|||..:.||..::...:|..|...||..|...: |:.|.....:|   :||:||:|.::..
Mouse   321 TPPYYDVSAMTVPIAVWNGGHDILADPQDVAMLLPKL-PNLLYHKEILP---YNHLDFIWAMDAP 381

  Fly   385 EILYDRVI 392
            :.:|:.::
Mouse   382 QEVYNEIV 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8093	NP_001286441.1	PLN02872	9..392	CDD:215470	136/388 (35%)
		Abhydro_lipase	31..92	CDD:282003	28/64 (44%)
		Abhydrolase_5	74..>214	CDD:289465	57/139 (41%)
Lipf	NP_080610.1	PLN02872	35..389	CDD:215470	131/362 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831698
Domainoid	1	1.000	227	1.000	Domainoid score	I2491
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	278	1.000	Inparanoid score	I2905
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8736
orthoMCL	1	0.900	-	-		OOG6_100408
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1506
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.840