DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8093 and LIPN

DIOPT Version :9

Sequence 1:	NP_001286441.1	Gene:	CG8093 / 36686	FlyBaseID:	FBgn0033999	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_001095939.1	Gene:	LIPN / 643418	HGNCID:	23452	Length:	398	Species:	Homo sapiens

Alignment Length:	403	Identity:	133/403 - (33%)
Similarity:	214/403 - (53%)	Gaps:	23/403 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLVVQLIAVFLSLGLANA-----LPADTGRASSVTTVTIVRGHGYEIEEHEVQTSDGYILTMHRI 60
            |:.:.|....|..|..||     |..:......:.|..|:..:||..||:||.|.|||||.::||
Human     1 MMWLLLTTTCLICGTLNAGGFLDLENEVNPEVWMNTSEIIIYNGYPSEEYEVTTEDGYILLVNRI 65

  Fly    61 PYSK-NTGYDGPRPVVFLMHGLLCSSSDWVLAGPHSGLAYLLSEAGYDVWMGNARGNTYSKRHAS 124
            ||.: :....||||||::.|.|...::.|:....:..|.:||::|||||||||:||||:|:||.:
Human    66 PYGRTHARSTGPRPVVYMQHALFADNAYWLENYANGSLGFLLADAGYDVWMGNSRGNTWSRRHKT 130

  Fly   125 KSPLLQPFWNFEWHDIGIYDLPAMMDYVLYWTNVTQLTYVGHSQGTTSFFVLNSMIPRFKSRIRS 189
            .|...:.||.|.:.::..||||.::|:::..|...:|.::|||.|||..||..|.:|....||:.
Human   131 LSETDEKFWAFSFDEMAKYDLPGVIDFIVNKTGQEKLYFIGHSLGTTIGFVAFSTMPELAQRIKM 195

  Fly   190 AHLLAPVAWMEHMESPLATVGGPLLGQPNAFVE-LFGSAEFLPNTQLMNLFGALLCSDEAISQFM 253
            ...|.|....::   |........| .||:.:: :||:..|....:...:....:|::: |...:
Human   196 NFALGPTISFKY---PTGIFTRFFL-LPNSIIKAVFGTKGFFLEDKKTKIASTKICNNK-ILWLI 255

  Fly   254 CTNTLFLLGGWNSPYINETLLPDIMATTPAGCSVNQIFHYLQEYNSGYFRQFDYGS-TRNKKEYS 317
            |:..:.|..|.|...:|::.:...|:..|.|.||:.|.|..|.|:|..||.:|:|: ..|.|.|:
Human   256 CSEFMSLWAGSNKKNMNQSRMDVYMSHAPTGSSVHNILHIKQLYHSDEFRAYDWGNDADNMKHYN 320

  Fly   318 SKTPPEYDVEGIDVPTYLYYSDNDYFASLIDVDRLRYTMNPSALKSAY---RMPEEKWNHIDFLW 379
            ...||.||:..:.|||.::...:|...:..||.|:.     ..:||.:   .:|:  |||.||:|
Human   321 QSHPPIYDLTAMKVPTAIWAGGHDVLVTPQDVARIL-----PQIKSLHYFKLLPD--WNHFDFVW 378

  Fly   380 GLNIKEILYDRVI 392
            ||:..:.:|..:|
Human   379 GLDAPQRMYSEII 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8093	NP_001286441.1	PLN02872	9..392	CDD:215470	130/393 (33%)
		Abhydro_lipase	31..92	CDD:282003	27/61 (44%)
		Abhydrolase_5	74..>214	CDD:289465	50/139 (36%)
LIPN	NP_001095939.1	Abhydro_lipase	36..97	CDD:282003	27/60 (45%)
		Abhydrolase_1	79..379	CDD:278959	100/311 (32%)
		Abhydrolase	106..>175	CDD:304388	32/68 (47%)
		Abhydrolase	<149..>234	CDD:304388	28/88 (32%)
		Abhydrolase_5	<322..374	CDD:289465	16/58 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141748
Domainoid	1	1.000	222	1.000	Domainoid score	I2592
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I3005
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	1	1.000	-	-		mtm8502
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910