DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment row and ZNF280C

DIOPT Version :9

Sequence 1:	NP_001260992.1	Gene:	row / 36685	FlyBaseID:	FBgn0033998	Length:	1301	Species:	Drosophila melanogaster
Sequence 2:	NP_060136.1	Gene:	ZNF280C / 55609	HGNCID:	25955	Length:	737	Species:	Homo sapiens

Alignment Length:	658	Identity:	142/658 - (21%)
Similarity:	227/658 - (34%)	Gaps:	234/658 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   571 QVATNPFKDWSILPANYKETPANAAPKRLKKPINDADYVVSNKIPKKEKDRDIASSGVKRGRPPN 635
            |.:..|.:|   :||.::|...|.: ..||.|....   |::..|||.|    .|..|.:..|..
Human   149 QESLPPSQD---IPAIFREGMKNTS-YVLKHPSTSK---VNSVTPKKPK----TSEDVPQINPST 202

  Fly   636 ALGTPPPQLPIKKGPGRPPGSTNQTKGDRATTSSS-----------------------------K 671
            :|    |.:      |.||.:::|....:.|.:||                             |
Human   203 SL----PLI------GSPPVTSSQVMLSKGTNTSSPYDAGADYLRACPKCNVQFNLLDPLKYHMK 257

  Fly   672 SLSKSLIAKGLG-----KKPKEKDE------KIPMVIKKEEDDLRGLEELYYGISDGTDEYHEIF 725
            .....:|.|.||     ::|.::|:      |:.|::          .|.|||..:|..|
Human   258 HCCPDMITKFLGVIVKSERPCDEDKTDSETGKLIMLV----------NEFYYGRHEGVTE----- 307

  Fly   726 PYSTPRTVHNELAKTVECPICLNGDSFDSNEKLQTHLVSHI-----SPEGKQHQFQCLFCLEKHP 785
              ..|:|.     .|.:|..|  .....:|.:...|:..|:     :.|..::...|..|..::|
Human   308 --KEPKTY-----TTFKCFSC--SKVLKNNIRFMNHMKHHLELEKQNNESWENHTTCQHCYRQYP 363

  Fly   786 TESVLAKHNQIMH-PTETKTEGSPSYYCLICQQRHNSLHLLTAHLQKVHSTLELPYWCHSCGYRS 849
            |...|..|.:..| |.|..|      .|.||:....:.|:|..|::..|...|:||.|..|.:||
Human   364 TPFQLQCHIESTHTPHEFST------ICKICELSFETEHILLQHMKDTHKPGEMPYVCQVCQFRS 422

  Fly   850 SSHRDLVRHFYDDHKHQNFLQCPYCLDIFYFSKLGVVNQLRIEHYFMHLDEHINKRDPSLRCQKC 914
            |:..|:..||...|::...|.||:||.:   ||:...   .:.||..|..:.::      ||.||
Human   423 STFSDVEAHFRAAHENTKNLLCPFCLKV---SKMATP---YMNHYMKHQKKGVH------RCPKC 475

  Fly   915 SLSFLEKGDLKQHAVQHH----------------VSMTKTNRPVRLLL----------NNSMLIP 953
            .|.||...:..:|..||.                |::..:..|::..|          .:.:.:.
Human   476 RLQFLTSKEKAEHKAQHRTFIKPKELEGLPPGAKVTIRASLGPLQSKLPTAPFGCAPGTSFLQVT 540

  Fly   954 PPKIRTHHREQPPFSTYKRPVFFAFLEGKT----------------------------------- 983
            ||..:......|..|...|        .||
Human   541 PPTSQNTTARNPRKSNASR--------SKTSKLHATTSTASKVNTSKPRGRIAKSKAKPSYKQKR 597

  Fly   984 -----------------------CAECNT---DFASEETHYTGWLHCVKCNYQTCCERAQFRHGV 1022
                                   |.||::   ||||   |::.::||..|.|.|.|.:|...|.:
Human   598 QRNRKNKMSLALKNIRCRRGIHKCIECHSKIKDFAS---HFSIYIHCSFCKYNTNCNKAFVNHMM 659

  Fly  1023 ECNGNFVDAMEVNMPQEMHCI-----------------CGF-ATGNG-NKMAQHLANCGLSTCYP 1068
            ..:.|.        |.:..||                 |.| |..:| ::||:||:.....||..
Human   660 SSHSNH--------PGKRFCIFKKHSGTLRGITLVCLKCDFLADSSGLDRMAKHLSQRKTHTCQV 716

  Fly  1069 SLEAASEN 1076
            .:|..|::
Human   717 IIENVSKS 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
row	NP_001260992.1	C2H2 Zn finger	777..798	CDD:275368	6/20 (30%)
		C2H2 Zn finger	812..833	CDD:275368	6/20 (30%)
		C2H2 Zn finger	842..858	CDD:275368	6/15 (40%)
ZNF280C	NP_060136.1	DUF4195	46..227	CDD:316361	25/98 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..137
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..223		15/63 (24%)
		C2H2 Zn finger	355..376	CDD:275368	6/20 (30%)
		C2H2 Zn finger	385..406	CDD:275368	6/20 (30%)
		C2H2 Zn finger	415..433	CDD:275368	7/17 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	535..602		7/74 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41152
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11181
SonicParanoid	1	1.000	-	-		X1818
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.900