DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment row and ZNF280D

DIOPT Version :9

Sequence 1:	NP_001260992.1	Gene:	row / 36685	FlyBaseID:	FBgn0033998	Length:	1301	Species:	Drosophila melanogaster
Sequence 2:	NP_001275517.1	Gene:	ZNF280D / 54816	HGNCID:	25953	Length:	979	Species:	Homo sapiens

Alignment Length:	798	Identity:	159/798 - (19%)
Similarity:	250/798 - (31%)	Gaps:	298/798 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   545 AFNNII--IHIAEQTRVTTNETITQRLYQVATNPFKDWSILPANYKETPANAAP----------- 596
            |.:||:  ::.:..:|...|..:::.:    |..||..|....|....|..|:|
Human    56 AISNILNRVNPSSYSRGLKNGALSRGI----TAAFKPTSQHYTNPTSNPVPASPINFHPESRSSD 116

  Fly   597 -----KRLKKP--INDADYVVSNK---------------------------------IPKKEKDR 621
                 :...||  |.::..|||||                                 :.|:....
Human   117 SSVIVQPFSKPGYITNSSRVVSNKSSELLFDLTQDTGLSHYQGGPTLSMAGMSESSFLSKRPSTS 181

  Fly   622 DIASSGVKRGRPPNAL--GTPPPQLPIKKGPGRPPGSTNQTKGDRATTSSSKS------------ 672
            ::.:...|:.:|..::  ......||..|.|..........||...:::.||:
Human   182 EVNNVNPKKPKPSESVSGANSSAVLPSVKSPSVTSSQAMLAKGTNTSSNQSKNGTPFPRACPKCN 246

  Fly   673 --------------------------LSKSLIAKGLGKKPKEKDEKIPMVIKKEEDDLRGLEELY 711
                                      |:|:..:..:.|......||..:::.        :.:.|
Human   247 IHFNLLDPLKNHMKYCCPDMINNFLGLAKTEFSSTVNKNTTIDSEKGKLIML--------VNDFY 303

  Fly   712 YGISDGTDEYHEIFPYSTPRTVHNELAKTVECPICLNGDSFDSNEKLQTHLVSHI-----SPEGK 771
            ||..:| |...|       :..|.    |.:|..||.  ...:|.:...|:..|:     |.|..
Human   304 YGKHEG-DVQEE-------QKTHT----TFKCFSCLK--ILKNNIRFMNHMKHHLELEKQSSESW 354

  Fly   772 QHQFQCLFCLEKHPTESVLAKHNQIMH-PTETKTEGSPSYYCLICQQRHNSLHLLTAHLQKVHST 835
            ::...|..|..:.||...|..|.:..| |.|..|      .|.||:....:.|:|..|::..|..
Human   355 ENHTTCQHCYRQFPTPFQLQCHIESTHTPHEFST------ICKICELSFETEHVLLQHMKDNHKP 413

  Fly   836 LELPYWCHSCGYRSSSHRDLVRHFYDDHKHQNFLQCPYCLDIFYFSKLGVVNQLRIEHYFMHLDE 900
            .|:||.|..|.|||||..|:..||...|::...|.||:||.:.   |:...   .:.||..|..:
Human   414 GEMPYVCQVCNYRSSSFSDVETHFRTSHENTKNLLCPFCLKVI---KIATP---YMHHYMKHQKK 472

  Fly   901 HINKRDPSLRCQKCSLSFLEKGDLKQHAVQHHVSMTK----------TNRPVRLLL--------- 946
            .|:      ||.||.|.||...:...|..|||.:..|          |...:|..:
Human   473 GIH------RCTKCRLQFLTCKEKMDHKTQHHRTFIKPKQLEGLPPGTKVTIRASVGPLQSGASP 531

  Fly   947 --------NNSMLIPP-----------------------------------------PKIRTHHR 962
                    :...|.||                                         |||....:
Human   532 TPSISASASTLQLSPPRTKNITAKNPAKSNTSKPNTVKSNASKPNTSKPNGSKSKYKPKISNMQK 596

  Fly   963 EQPPFST---------------YKRPVFFAFLEGKTCAECNTDFASEETHYTGWLHCVKCNYQTC 1012
            :|...::               |:|.:       ..|.||.::......|:..::||..|.|.|.
Human   597 KQSTLASSNKKSKVNTALRNLRYRRGI-------HKCIECCSEIKDFANHFPTYVHCSFCRYNTS 654

  Fly  1013 CERAQFRHGVECNGNFVDAMEVNMPQEMHCI-----------------CGF---ATGNGNKMAQH 1057
            |.:|...|        :.:...|.|.:..||                 |.|   .:|..| ||.|
Human   655 CSKAYVNH--------MMSFHSNRPSKRFCIFKKHSENLRGITLVCLNCDFLSDVSGLDN-MATH 710

  Fly  1058 LA-----NC-----GLSTCYPSLEAASE---------------NAVKRNMLDMLGLVRRDGETSG 1097
            |:     .|     .:|.|.|:.|..||               ...:.||.:      |:.|||.
Human   711 LSQHKTHTCQVVMQKVSVCIPTSEHLSELKKEAPAKEQEPVSKEIARPNMAE------RETETSN 769

  Fly  1098 EGADISETADDVADQSSD 1115
                 ||:..|.|..|.:
Human   770 -----SESKQDKAASSKE 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
row	NP_001260992.1	C2H2 Zn finger	777..798	CDD:275368	6/20 (30%)
		C2H2 Zn finger	812..833	CDD:275368	6/20 (30%)
		C2H2 Zn finger	842..858	CDD:275368	8/15 (53%)
ZNF280D	NP_001275517.1	DUF4195	45..229	CDD:290548	30/176 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..119		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..236		11/78 (14%)
		C2H2 Zn finger	360..381	CDD:275368	6/20 (30%)
		C2H2 Zn finger	390..411	CDD:275368	6/20 (30%)
		C2H2 Zn finger	420..439	CDD:275368	10/18 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..608		7/84 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..809		11/55 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	896..979
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41152
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11181
SonicParanoid	1	1.000	-	-		X1818
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.900