DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment row and pogza

DIOPT Version :9

Sequence 1:	NP_001260992.1	Gene:	row / 36685	FlyBaseID:	FBgn0033998	Length:	1301	Species:	Drosophila melanogaster
Sequence 2:	NP_001201839.1	Gene:	pogza / 100535215	ZFINID:	ZDB-GENE-040914-76	Length:	1277	Species:	Danio rerio

Alignment Length:	822	Identity:	174/822 - (21%)
Similarity:	275/822 - (33%)	Gaps:	257/822 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   581 SILPANYKET---------PA-NAAPKRLKKPINDADY------VVSNKIPKKEKDRDIASSGVK 629
            |||||...:|         || ..|...||:..:.:.:      |....:|.:......:...:|
Zfish   241 SILPAGIAQTLMPQMQILAPAPGTASNALKRTSSSSTFCPRCKAVYQKSLPLRGYFCQCSQELIK 305

  Fly   630 -----RGRPPNALGTPPPQLPIKKGPGRPPGSTNQTKGDRATTSSSKSLSKSLIAKGL---GKKP 686
                 :....|.|         :....|||..|      .|:::|||:..|.:.:..|   ...|
Zfish   306 SIWSLKSHTKNRL---------RARSKRPPRDT------PASSASSKTSQKDVTSCELPEGAPNP 355

  Fly   687 K--EKDEKIPMVIKKEEDDLRGLEELYYGISDGTDEYHEIFPYSTPRTVHNELAK-TVECPICLN 748
            :  :.||:..|::.        :|:.:||...|           .|..|...... :::|.:|
Zfish   356 RSGDFDEQGRMIML--------VEDFFYGQHPG-----------RPADVRYPWEHISMKCHLC-- 399

  Fly   749 GDSFDSNEKLQTHLVSHISPEGKQHQFQ----CLFCLEKHPTESVLAKHNQIMHPTETKTEGSPS 809
            ......|.::..|:..|:..:.:..:..    |..|.....|...|..|.:.:|     .:...|
Zfish   400 SKKLIGNIEMMNHMKHHMERDCRTGEVDCHTVCQHCYRNFSTPFGLQCHVEAVH-----IQAESS 459

  Fly   810 YYCLICQQRHNSLHLLTAHLQKVHSTLELPYWCHSCGYRSSSHRDLVRHFYDDHKHQNFLQCPYC 874
            ..|.||:....|..|...|::.||...|:||.|..|.:|||.::|::.||.:.||....|.|.||
Zfish   460 KVCKICECLFESEPLFLNHMKHVHKPGEMPYVCKVCDFRSSFYKDVMNHFTEHHKDTCILLCVYC 524

  Fly   875 LDIFYFSKLGVVNQLRIEHYFMHLDEHINKRDPSLRCQKCSLSFLEKGDLKQHAVQHHVSMTKTN 939
            |.|  |...|.. ||   ||..|      ::..:..|.||.|.|..:.|...|..:.|.:..|..
Zfish   525 LKI--FRSCGGF-QL---HYTRH------QKKGARNCDKCRLQFCSEKDEWHHKQRFHRTYVKPK 577

  Fly   940 RPVRLLLNNSMLIPPPKIRTHHREQ---PPFS---------------------TYKRPV------ 974
            :...|:....::|......|.:|.|   ||..                     ..|:||
Zfish   578 QLEGLVPGTRIIIRAYADNTDNRAQFGEPPVEPCPNTTSTPDQSQNVHSKIVPVKKKPVESMVEL 642

  Fly   975 ---FFAFLEGKT----CAECNTDFASEETHYTGWLHCVKCNYQTCCERAQFRHGVECNGNFVDAM 1032
               |.:....|.    |.|||.|......|:..::.|..|.|.|||.||...|          .:
Zfish   643 MVKFESNFNPKEKKYYCMECNHDIPYFSNHFPTYVSCSLCRYCTCCSRAYANH----------MI 697

  Fly  1033 EVNMPQE-----------------MHCI-CGFATGNGNKMAQHLANCGLSTCYPSLEAAS----- 1074
            .|::|::                 :.|. |.|.|..|:.||:||||      :|..:|:.
Zfish   698 SVHVPRKSTKKYITLYKPCPKKGRLSCTKCKFNTTIGDSMAKHLAN------FPKHQASRSTIQE 756

  Fly  1075 --ENAVKRNMLDMLGLVRRDGETSGEG---ADISETADDVADQSSDM-----------------L 1117
              ....||.:.....|:|.....:..|   ..:.:     .|:||.:                 :
Zfish   757 GFSQGYKRFVFIPTNLLRGGQRLNNTGFLHLQVKQ-----VDRSSSIPLLQPSYTITLPASPARM 816

  Fly  1118 PPQEDHHLQQHHQQVGHQQQMQGQPNEPQAELQQEYLSAPVEHEPVQNMPVHQSMPVQQTGPIQF 1182
            ||                ..:|.||.|..            :..|:...|...|:...|...:.:
Zfish   817 PP----------------LPIQAQPTEKS------------KVRPIAPKPALHSLTAAQNKVVLY 853

  Fly  1183 ----GEMEAA-----------PVLLDTQQQVQP-------TPDYAQVSVVQ----QHQQQQPYG- 1220
                |..:||           .:||..|..|:|       ||..|. .::|    |.:||.|..
Zfish   854 ALCCGVPQAAIHFNKPPEEVHSLLLKRQTVVEPSKGKYFLTPQAAD-KLIQWVYCQREQQLPISE 917

  Fly  1221 ------LSNYGQSSLATDI--------DMPLIGELSEPNAPP 1248
                  :.|:|....:.|.        |:.|....:....||
Zfish   918 ANLLEFMYNHGSRDFSYDSVVDFFLRHDLGLQAFATSSKLPP 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
row	NP_001260992.1	C2H2 Zn finger	777..798	CDD:275368	5/20 (25%)
		C2H2 Zn finger	812..833	CDD:275368	6/20 (30%)
		C2H2 Zn finger	842..858	CDD:275368	6/15 (40%)
pogza	NP_001201839.1	C2H2 Zn finger	432..453	CDD:275368	5/20 (25%)
		C2H2 Zn finger	462..483	CDD:275368	6/20 (30%)
		rve	1027..>1134	CDD:304425
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BHCU
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24332
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11181
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.800