DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment row and pogz

DIOPT Version :9

Sequence 1:	NP_001260992.1	Gene:	row / 36685	FlyBaseID:	FBgn0033998	Length:	1301	Species:	Drosophila melanogaster
Sequence 2:	XP_031746618.1	Gene:	pogz / 100158529	XenbaseID:	XB-GENE-6257670	Length:	1373	Species:	Xenopus tropicalis

Alignment Length:	868	Identity:	180/868 - (20%)
Similarity:	284/868 - (32%)	Gaps:	281/868 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   559 VTTNETITQRLYQVATNPFKDWSILPANYKETPANAAPKRLKKPINDADYVVSNK---------- 613
            :.|....:|.:.|:|..| :...||..|..   :.:....|.|.::.|:.|..||
Frog   256 MATTSAPSQPIRQIAMQP-QQTQILATNQN---SQSTSSNLGKLVSIANLVAVNKTGEPNDLVKF 316

  Fly   614 ------------------IPK-KEKDRDIASSGVKRGRPPNALGTP------------------- 640
                              :|. .......:||.|:|..||...|..
Frog   317 VNAVSGNQSAVLNSSQIVLPSTTSSSTSNSSSTVQRILPPEPSGMKCTAASVSSADSSDSNRKFC 381

  Fly   641 ---------------------PPQLPI--KKGPGRPPGSTNQT----KGDRATTSSSKSLSKSLI 678
                                 |..|..  |......|..|.|.    |...|.|.||.:.|.:..
Frog   382 PRCRAQFRVTEALRGHMCYCCPDLLDFSNKSKESELPSQTTQAICTDKIISAATPSSTTPSTTAP 446

  Fly   679 AKGLGKKPKEKDEKIPMVIKKEEDDLRG-----LEELYYGISDGTDEYHEIFPYSTPRTVHNELA 738
            ..|.|::            ..:|:.::|     :::.|||...|.....:.:|         ::|
Frog   447 PAGKGQE------------SSQEEGMQGKLIMLVDDFYYGRDVGNTYQMQSYP---------KVA 490

  Fly   739 KTVECPICLNGDSFDSNEKLQTHLVSHISPEGKQHQFQ----CLFCLEKHPTESVLAKHNQIMHP 799
            .|..||.|..  ...:|.:...|:..|:..:.:..:..    |..|..:..|...|..|.:.:|.
Frog   491 TTFRCPHCTK--RLKNNIRFMNHMKHHVELDQQNGEVDGHTTCQHCYRQFSTPFQLQCHLENVHS 553

  Fly   800 T-ETKTEGSPSYYCLICQQRHNSLHLLTAHLQKVHSTLELPYWCHSCGYRSSSHRDLVRHFYDDH 863
            : |:.|:      |.||:...:|..|...|::..|...|:||.|..|.||||.:.::..||..:|
Frog   554 SYESTTK------CKICEWAFDSEPLFLQHMKDTHKPGEMPYVCQVCQYRSSIYAEVDTHFRLNH 612

  Fly   864 KHQNFLQCPYCLDIFYFSKLGVVNQLRIEHYFMHLDEHINKRDPSLRCQKCSLSFLEKGDLKQHA 928
            :...:|.|.|||.:|   |.|...|   :|:..|       :.....|.||.|.||...|..:|.
Frog   613 EDTRYLMCVYCLKVF---KNGNAFQ---QHFMRH-------QKSVYHCNKCRLQFLFAKDKIEHK 664

  Fly   929 VQHHVSMTK----------TNRPVRLLLNNSMLIPPPKIRTH----------------------- 960
            :|||.:..|          |...:|.....|..:|.....|.
Frog   665 LQHHKTFRKPRQLEGLKPGTKVTIRASRAPSRSLPVSSADTTSMPLVDMDTDSLADSLYSMQYKR 729

  Fly   961 ------------HREQPPFSTYKRPVFFAFLEGKTCAECNTDFASEETHYTGWLHCVKCNYQTCC 1013
                        |.::||:..            ::|.||:.|....:.|:..::||..|.|.|||
Frog   730 TVKKTSENLSNIHTKRPPYGR------------QSCLECSLDITDFQNHFPTYVHCSLCRYSTCC 782

  Fly  1014 ERAQFRHGV----------------ECNGNFVDAMEVNMPQEMHCICGFATGNGNKMAQHLA-NC 1061
            .||...|.:                .|..:.|.|:..:.       |.|.|..|:.||:||. |.
Frog   783 SRAYANHMINNHVPRKSPKYLALFKSCKPSSVVALTCSS-------CPFVTRIGDAMAKHLVFNP 840

  Fly  1062 GLSTC---YP-SLEAASENAVKRNMLDMLGLVRRDGETSGEGADISETADDVADQSSDMLPPQED 1122
            ..|.|   || |..:.......:...|.:...|....|.|....:||.|          ||..|.
Frog   841 AHSYCNVIYPGSSSSCFLRMASKTQEDDVRSYRTAVATVGTSEKVSEEA----------LPVSEA 895

  Fly  1123 HHLQQHHQQVGH-------QQQMQGQPN-----EPQAELQQEYLSA----------------PVE 1159
            ..|    ::|.|       :::::.:|:     |.:|:.:||.||.                ..|
Frog   896 PSL----EEVNHTINVEELEEELEEKPDEAEAGEQEAQNKQEQLSVKKLRVVLFALCCNIQQAAE 956

  Fly  1160 HEPVQNMPVH--------QSMPVQQTGPIQFGEMEAAPVLLDTQQQVQPTPDYAQVSVVQQHQQQ 1216
            |  ..|.|..        |:...:....:..|:...|    :.::::...       |:.|.:||
Frog   957 H--FHNSPQRIRRWLQRFQTFQEENQDNLSEGKYLGA----EAEEKLAEW-------VLAQREQQ 1008

  Fly  1217 QPYGLSNYGQSSLATDIDMPLIG 1239
            ||.......|.  ||.|...|.|
Frog  1009 QPVNEETLFQK--ATKIGRSLEG 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
row	NP_001260992.1	C2H2 Zn finger	777..798	CDD:275368	5/20 (25%)
		C2H2 Zn finger	812..833	CDD:275368	6/20 (30%)
		C2H2 Zn finger	842..858	CDD:275368	6/15 (40%)
pogz	XP_031746618.1	SP1-4_N	<94..291	CDD:425404	8/38 (21%)
		C2H2 Zn finger	495..528	CDD:275371	6/34 (18%)
		C2H2 Zn finger	531..552	CDD:275368	5/20 (25%)
		C2H2 Zn finger	561..582	CDD:275368	6/20 (30%)
		C2H2 Zn finger	620..646	CDD:275371	10/38 (26%)
		HTH_28	938..>975	CDD:404412	5/38 (13%)
		CENPB	987..1049	CDD:197828	13/56 (23%)
		rve	1124..>1237	CDD:419726
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48362
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1818
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000