DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment row and znf280d

DIOPT Version :9

Sequence 1:	NP_001260992.1	Gene:	row / 36685	FlyBaseID:	FBgn0033998	Length:	1301	Species:	Drosophila melanogaster
Sequence 2:	XP_002940298.3	Gene:	znf280d / 100144635	XenbaseID:	XB-GENE-479902	Length:	1071	Species:	Xenopus tropicalis

Alignment Length:	816	Identity:	175/816 - (21%)
Similarity:	286/816 - (35%)	Gaps:	233/816 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   593 NAAPKRLKKPINDADYVVSNKIPKKEKDRD--------IASSGVKRGRPPNALGTPPPQL----P 645
            |.|.::...||.     :|:..|||.|:|:        .:|:..|           ||.|    |
Frog   285 NTATEKRAAPIE-----ISDISPKKTKNRENECDSRFFDSSTSAK-----------PPMLLQSSP 333

  Fly   646 IKKGPGRPPGSTNQTKGDRATTSSSKSLSKSLIAKGLGKK-----PKEKDEKIPMVIKKE----- 700
            .|...|...|:|:: .|.....:..|......:::.:.|.     |.:.|.....|...|
Frog   334 TKVNAGTSSGTTSK-HGPPIPQACPKCNIHFNLSEPMRKHMKFCCPDKVDHFFSGVTNSEAVNAS 397

  Fly   701 ---EDDLRG-----LEELYYGISDGTDEYHEIFPYSTPRTVHNELAKTVECPICLNGDSFDSNEK 757
               ||..:|     :.:.|||...|     :::.....|..|.    |.:|..|  .....:|.:
Frog   398 GIIEDAEKGKLIMLVSDFYYGRYGG-----DLYLAQLERKTHT----TFKCFSC--HKILKNNIR 451

  Fly   758 LQTHLVSHI-----SPEGKQHQFQCLFCLEKHPTESVLAKHNQIMHPTETKTEGSPSYYCLICQQ 817
            ...|:..|:     |.|..::...|..|..:.||...|..|.:..|     |....|..|.||:.
Frog   452 FMNHMKHHLELEMQSNESWENHTTCHHCYRQFPTPFQLQCHIESSH-----TLYESSTICKICEL 511

  Fly   818 RHNSLHLLTAHLQKVHSTLELPYWCHSCGYRSSSHRDLVRHFYDDHKHQNFLQCPYCLDIFYFSK 882
            ...|..:|..|::..|...|:||.|..||||||::.::..||...|::...|.||:||.:.   |
Frog   512 SFESEQILLQHMKDNHKPGEMPYVCQVCGYRSSAYAEVDSHFRFAHENTKSLLCPFCLKVI---K 573

  Fly   883 LGVVNQLRIEHYFMHLDEHINKRDPSLRCQKCSLSFLEKGDLKQHAVQHHVSMTK---------- 937
            .|.       .|..|..:|.||  ...||..|.|.||...:...|..|||.:..|
Frog   574 SGT-------PYMQHYMKHQNK--GVYRCANCRLQFLTCKEKMDHKTQHHRTFRKPKQLEGLPPG 629

  Fly   938 ------------------------TNRPVRLL-------LNNSML----------------IPPP 955
                                    |:.|...|       :.|:.:                ||||
Frog   630 TKVTIRASVGSIVNSVHSPTNTACTSPPSTALQASSISKITNAKITQGPLVKSNVQNTKPKIPPP 694

  Fly   956 KIRTHHREQPPFSTYKRPV---------FFAFLEGKTCAECNTDFASEETHYTGWLHCVKCNYQT 1011
            |      ::|..:|.|:.:         ..:......|.||..:....|.|:...:||.||.:.|
Frog   695 K------KKPVSTTSKKRIKMINTALRNLRSVAGYHKCIECQLEVKDFEGHFHTHVHCTKCKFST 753

  Fly  1012 CCERAQFRHGVECNGNFVDAMEVNMPQE---------MHCI-CGFATGNG--NKMAQHLANCGLS 1064
            .|.:|...|.:..:|. ..:.:....::         :.|: |.|.|...  :.||:||:.....
Frog   754 SCNKAYTNHMIRFHGR-SSSKQAKASKKAAKGIRRITLVCLNCDFLTDVSCLDDMAKHLSESHSH 817

  Fly  1065 TCYPSLEAAS--------ENAVKRNMLDMLG-------LVRRDGETS-----GEGADISETADDV 1109
            :|...||..|        :.|..||. .::|       ::..:.:||     ||...:....::.
Frog   818 SCQVILENVSIFSSTLEGDMAKSRNE-SLVGERHNYCKIMLYETKTSTNQSKGETNTLKTIKENS 881

  Fly  1110 ADQSSDMLPPQEDHHLQQHH------QQVGHQQQMQGQPNEP-----QAELQQEYLSAPVEHEPV 1163
            ..:||.|...|.:..|...|      .:...|....|....|     |.:...:.|.:.||.|.:
Frog   882 TSESSKMSDVQSNLSLHDIHVTPVEPVKDSDQTTQDGCNTNPIIGIAQTDSDDKGLMSSVEEETL 946

  Fly  1164 Q---NMPVHQSMP---VQQTGPIQFGEMEAAPVLLDTQQQVQ-PTPDYA--QVSVVQ-QHQQQQP 1218
            .   ::....::.   :..|.      .|:.|.|.|....:: |.|::|  :.|.|| ..::.:|
Frog   947 NRDLSLETDHNLDNKCICDTA------NESKPSLEDVIPNIESPNPNFACEENSFVQFLRRRDEP 1005

  Fly  1219 YGLSNYGQSSLATDIDMPLIGELSEPNA----PPTP 1250
                    .|:.:|:        ||.::    |.||
Frog  1006 --------ESICSDV--------SEQSSVHLEPLTP 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
row	NP_001260992.1	C2H2 Zn finger	777..798	CDD:275368	6/20 (30%)
		C2H2 Zn finger	812..833	CDD:275368	6/20 (30%)
		C2H2 Zn finger	842..858	CDD:275368	7/15 (47%)
znf280d	XP_002940298.3	DUF4195	32..>94	CDD:404681
		PHA03247	<77..294	CDD:223021	2/8 (25%)
		C2H2 Zn finger	439..473	CDD:275371	7/35 (20%)
		C2H2 Zn finger	476..497	CDD:275368	6/20 (30%)
		C2H2 Zn finger	506..527	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48362
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1818
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000