Protein Alignment CG11807 and Nisch

DIOPT Version :10

• Sequence 1: NP_611017.1
• Gene: CG11807 / 36683
• FlyBaseID: FBgn0033996
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_073147.2
• Gene: Nisch / 64652
• MGIID: 1928323
• Length: 1593
• Species: Mus musculus
• Alignment Length: 466
• Identity: 178/466 - (38%)
• Similarity: 252/466 - (54%)
• Gaps: 43/466 - (9%)

  Fly    28 TYYDIKVRVGKVEWLVERRYRDFANLHEKLVGEISISKKLLPPKKLVGNKQPSFLEQRREQLEIY 92
            |.|.|:|..|..||.::.||.||.:||||||.|..|.|.||||||::|....|.:|:|...||:|
Mouse    32 TVYVIQVTDGNHEWTIKHRYSDFHDLHEKLVAERKIDKSLLPPKKIIGKNSRSLVEKRERDLEVY 96

  Fly    93 LQELLIYFRTELPRALAEFLDFNKYDIIYLLQDLAKLFNESGDALLSSKKEYNLSALEVYAISER 157
            ||.||..|....||.||.||.|:.|::..:...||:...|.|:.||.:.:.:.:..|::|||:|:
Mouse    97 LQTLLTTFPDVAPRVLAHFLHFHLYEVNGVTAALAEELFEKGEQLLGAGEVFAIRPLQLYAITEQ 161

  Fly   158 LSLPCPPSLDRGGKYDFSHVLDFCTQLVALVVTPVKDNASYAQDYNTVDVPIDRSNIIPNRLSFN 222
            |....|.......|.|..|:|||..:|..|.|:..:.             |...|||....|.|:
Mouse   162 LQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEG-------------PFGTSNIKEQLLPFD 213

  Fly   223 LNAFRNLKTLKFSALSTENIVDIELLKPTLQTICVH--NTTIQNINQVLLCDNLHKHCDVPSLLP 285
            |:.|::|..::.|....::|..:...||||.|:.|.  .|:::.:                 |.|
Mouse   214 LSIFKSLHQVEISHCDAKHIRGLVTSKPTLATMSVRFSATSMKEV-----------------LAP 261

  Fly   286 ETILAS------PSGSGPSTSNGSALVSADAWQEITELDLTGNLLTQIDGSVRTAPKLRRLILDQ 344
            |   ||      |.|:  :|..|........||.:|.|||:.|.:.:||.||:..||:..|.|..
Mouse   262 E---ASEFDEWEPEGT--ATLGGPVTAIIPTWQALTTLDLSHNSICEIDESVKLIPKIEYLDLSH 321

  Fly   345 NRIRTVQNLAELPQLQLLSLSGNLIAECVDWHLTMGNLVTLKLAQNKIKTLSGLRKLLSLVNLDL 409
            |.:|.|.||..|..|..|.||.|.::.....|..:||:.||.||.|.:::||||.||.||||:||
Mouse   322 NGLRVVDNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNVKTLNLAGNFLESLSGLHKLYSLVNVDL 386

  Fly   410 SSNQIEELDEVNHVANLPLLETLRLTGNPLAGSVDYRSRVLARFHERAAEISLDNEPGNQQELDT 474
            ..|:||:||||..:.:||.||.|.|..|||:...|||::||::|.|||:||.||:....::||||
Mouse   387 RDNRIEQLDEVKSIGSLPCLERLTLLNNPLSIIPDYRTKVLSQFGERASEICLDDVATTEKELDT 451

  Fly   475 ALVLSALLQSK 485
            ..||.|:.::|
Mouse   452 VEVLKAIQKAK 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11807	NP_611017.1	PX_IRAS	8..126	CDD:132785	46/97 (47%)
		PPP1R42	<314..451	CDD:455733	64/136 (47%)
		leucine-rich repeat	315..336	CDD:275380	9/20 (45%)
		leucine-rich repeat	337..381	CDD:275380	14/43 (33%)
		leucine-rich repeat	382..403	CDD:275380	11/20 (55%)
		leucine-rich repeat	404..428	CDD:275380	13/23 (57%)
Nisch	NP_073147.2	Necessary for binding to phosphoinositide-3-P, not sufficient for targeting to endosomes. /evidence=ECO:0000250	1..134		48/101 (48%)
		PX_IRAS	15..130	CDD:132785	46/97 (47%)
		Necessary for homooligomerization and targeting to endosomes. /evidence=ECO:0000250	121..695		133/377 (35%)
		Interaction with PAK1. /evidence=ECO:0000269|PubMed:15229651	246..869		94/239 (39%)
		LRR	<285..>419	CDD:443914	62/133 (47%)
		leucine-rich repeat	291..313	CDD:275380	9/21 (43%)
		leucine-rich repeat	314..335	CDD:275380	8/20 (40%)
		leucine-rich repeat	336..358	CDD:275380	6/21 (29%)
		leucine-rich repeat	359..380	CDD:275380	11/20 (55%)
		leucine-rich repeat	381..405	CDD:275380	13/23 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	466..499
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	629..687
		Interaction with LIMK	661..869
		Interaction with ITGA5	709..807
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1016..1185
		10 X 6 AA tandem repeat of A-E-A-P-A-A	1081..1146