DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11807 and Nisch

DIOPT Version :9

Sequence 1:	NP_001260990.1	Gene:	CG11807 / 36683	FlyBaseID:	FBgn0033996	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	XP_001057307.5	Gene:	Nisch / 306255	RGDID:	1306950	Length:	1646	Species:	Rattus norvegicus

Alignment Length:	464	Identity:	178/464 - (38%)
Similarity:	252/464 - (54%)	Gaps:	40/464 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 TYYDIKVRVGKVEWLVERRYRDFANLHEKLVGEISISKKLLPPKKLVGNKQPSFLEQRREQLEIY 92
            |.|.|:|..|..||.::.||.||.:||||||.|..|.|.||||||::|....|.:|:|.:.||:|
  Rat    32 TVYVIQVTDGNHEWTIKHRYSDFHDLHEKLVAERKIDKTLLPPKKIIGKNSRSLVEKREKDLEVY 96

  Fly    93 LQELLIYFRTELPRALAEFLDFNKYDIIYLLQDLAKLFNESGDALLSSKKEYNLSALEVYAISER 157
            ||.||..|....||.||.||.|:.|:|..:...||:...|.|:.||.:.:.:.:..|::|||:|:
  Rat    97 LQTLLKTFPDVAPRVLAHFLHFHLYEINGVTAALAEELFEKGEQLLGAGEVFAIRPLQLYAITEQ 161

  Fly   158 LSLPCPPSLDRGGKYDFSHVLDFCTQLVALVVTPVKDNASYAQDYNTVDVPIDRSNIIPNRLSFN 222
            |....|.......|.|..|:|||..:|..|.|:..:.             |...|||....|.|:
  Rat   162 LQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEG-------------PFGTSNIREQLLPFD 213

  Fly   223 LNAFRNLKTLKFSALSTENIVDIELLKPTLQTICVHNTTIQNINQVLLCDNLHKHCDVPSLLPET 287
            |:.|::|..::.|....:::..:...||||.|:.| ..:..::.:|              |:||
  Rat   214 LSIFKSLHQVEMSHCDAKHVRGLVTSKPTLATMSV-RFSAASMKEV--------------LVPE- 262

  Fly   288 ILAS------PSGSGPSTSNGSALVSADAWQEITELDLTGNLLTQIDGSVRTAPKLRRLILDQNR 346
              ||      |.|   :|..|........||.:|.|||:.|.:::||.||:..||:..|.|..|.
  Rat   263 --ASEFDEWEPEG---TTLGGPVTAVIPTWQALTTLDLSHNSISEIDESVKLIPKIEYLDLSHNG 322

  Fly   347 IRTVQNLAELPQLQLLSLSGNLIAECVDWHLTMGNLVTLKLAQNKIKTLSGLRKLLSLVNLDLSS 411
            :..|.||..|..|..|.||.|.::.....|..:||:.||.||.|.::.||||.||.|||||||..
  Rat   323 VLVVDNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNVKTLNLAGNFLERLSGLHKLYSLVNLDLRD 387

  Fly   412 NQIEELDEVNHVANLPLLETLRLTGNPLAGSVDYRSRVLARFHERAAEISLDNEPGNQQELDTAL 476
            |:||:||||..:.|||.||.:.|..|||:...|||::||::|.|||:||.||:....::||||..
  Rat   388 NRIEQLDEVKSIGNLPCLEHVALLNNPLSIIPDYRTKVLSQFGERASEICLDDVATTEKELDTVE 452

  Fly   477 VLSALLQSK 485
            ||.|:.::|
  Rat   453 VLKAIQKAK 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11807	NP_001260990.1	PX_IRAS	8..126	CDD:132785	47/97 (48%)
		leucine-rich repeat	315..336	CDD:275380	9/20 (45%)
		LRR_8	335..414	CDD:290566	36/78 (46%)
		leucine-rich repeat	337..381	CDD:275380	13/43 (30%)
		LRR_4	381..422	CDD:289563	26/40 (65%)
		leucine-rich repeat	382..403	CDD:275380	11/20 (55%)
		leucine-rich repeat	404..428	CDD:275380	15/23 (65%)
Nisch	XP_001057307.5	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354029
Domainoid	1	1.000	87	1.000	Domainoid score	I7869
eggNOG	1	0.900	-	-		E1_KOG1859
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H130564
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006271
OrthoInspector	1	1.000	-	-		oto97960
orthoMCL	1	0.900	-	-		OOG6_107027
Panther	1	1.100	-	-	LDO	PTHR15454
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4560
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.740