Protein Alignment CG11807 and nish-1

DIOPT Version :10

• Sequence 1: NP_611017.1
• Gene: CG11807 / 36683
• FlyBaseID: FBgn0033996
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_502016.2
• Gene: nish-1 / 177981
• WormBaseID: WBGene00008750
• Length: 497
• Species: Caenorhabditis elegans
• Alignment Length: 482
• Identity: 153/482 - (31%)
• Similarity: 241/482 - (50%)
• Gaps: 57/482 - (11%)

  Fly    25 GGVTYYDIKVRVGKVEWLVERRYRDF--ANLHEKLVGEISISKKLLPPKKLVGNKQPSFLEQRRE 87
            |..|.|.|::.|....|.|||||.||  .::|..|    ...|..|||||.:|||...|:|:||.
 Worm    30 GKYTVYRIQITVDTYTWTVERRYSDFDAYDVHRFL----DRKKSFLPPKKRLGNKDLEFIEERRL 90

  Fly    88 QLEIYLQELL---IYFRTE-----LPRALAEFLDFNKYDIIYLLQDLAKLFNESGDALL----SS 140
            :||.|::.||   ::::.:     ||...|:|.||::|:|..::.||:......||..|    :|
 Worm    91 ELEKYVRALLELEVWYQKQKNVHSLPLITAKFFDFHQYEIHSIVDDLSLRLGNLGDGWLESSQTS 155

  Fly   141 KKEYNLSALEVYAISERLSLPCPPSLDRGGKYDFSHVLDFCTQLVALVVTPVKDNASYAQDYNTV 205
            .|.:..:.:|::||:|||.||.|.:.|.....|..:.:||..::.||   .::....|
 Worm   156 PKYFEFTPIELHAITERLRLPEPTAPDVNMVADIGNTIDFLHRVRAL---KIRGQKGY------- 210

  Fly   206 DVPIDRSNIIPNRLSFNLNAFRNLKTLKFSALSTENIVDIELLKPTLQTICVHNTTIQNINQVLL 270
               :..|||:.|.|..:|...:.||.|..:......|..|:.::.||:.:.|| .:::.|..:|.
 Worm   211 ---VGTSNIVWNSLDMSLYFCKGLKALWIADSDVCRINGIKSIRETLRRLVVH-YSMKKIKDLLF 271

  Fly   271 CDNLHKHCDVPSLLPETILASPSGSGPSTSNGSALVSADAWQEITELDLTGNLLTQIDGSVRTAP 335
            .:.                        ....|..:...|.|:.:.|:||:.|.:...|.|::..|
 Worm   272 DEE------------------------DLETGMLVEEMDTWKCLEEVDLSFNEIKCFDESMKLLP 312

  Fly   336 KLRRLILDQNRIRTV-QNLAELPQLQLLSLSGNLIAECVDWHLTMGNLVTLKLAQNKIKTLSGLR 399
            ::|.|.:..|.|..: .|||.|..|..|.||.|.:.:...|:..:||:..|.|::|.|:.||||.
 Worm   313 EVRVLNVSYNSITEIGSNLAFLSSLTELDLSNNTLTKIDGWNEKLGNIKKLILSENAIEDLSGLG 377

  Fly   400 KLLSLVNLDLSSNQIEELDEVNHVANLPLLETLRLTGNPLAGSVDYRSRVLARFHERAAEISLDN 464
            ||.||..||...|.|:.||.|..:..||.||.|.|..||:...|:||::||..|.||::|:.||.
 Worm   378 KLYSLEYLDAKGNNIQNLDAVQGIGKLPCLEILLLRDNPIRKLVEYRTKVLELFGERSSELKLDG 442

  Fly   465 EPGNQQELDTALVLSALLQSKQRQQQK 491
            .....:||||..|..||.::|:.::::
 Worm   443 RRPEARELDTVRVRMALRKAKEEKEER 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11807	NP_611017.1	PX_IRAS	8..126	CDD:132785	41/110 (37%)
		PPP1R42	<314..451	CDD:455733	54/137 (39%)
		leucine-rich repeat	315..336	CDD:275380	6/20 (30%)
		leucine-rich repeat	337..381	CDD:275380	14/44 (32%)
		leucine-rich repeat	382..403	CDD:275380	10/20 (50%)
		leucine-rich repeat	404..428	CDD:275380	9/23 (39%)
nish-1	NP_502016.2	PX_domain	18..137	CDD:470617	41/110 (37%)
		LRR	<245..>420	CDD:443914	60/199 (30%)
		leucine-rich repeat	291..313	CDD:275380	6/21 (29%)
		leucine-rich repeat	314..336	CDD:275380	8/21 (38%)
		leucine-rich repeat	337..359	CDD:275380	6/21 (29%)
		leucine-rich repeat	360..381	CDD:275380	10/20 (50%)
		leucine-rich repeat	382..406	CDD:275380	9/23 (39%)