Protein Alignment CG11807 and NISCH

DIOPT Version :10

• Sequence 1: NP_611017.1
• Gene: CG11807 / 36683
• FlyBaseID: FBgn0033996
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_009115.3
• Gene: NISCH / 11188
• HGNCID: 18006
• Length: 1504
• Species: Homo sapiens
• Alignment Length: 467
• Identity: 176/467 - (37%)
• Similarity: 255/467 - (54%)
• Gaps: 44/467 - (9%)

  Fly    28 TYYDIKVRVGKVEWLVERRYRDFANLHEKLVGEISISKKLLPPKKLVGNKQPSFLEQRREQLEIY 92
            |.|.|:|..|..||.|:.||.||.:||||||.|..|.|.||||||::|....|.:|:|.:.||:|
Human    31 TVYIIQVTDGSHEWTVKHRYSDFHDLHEKLVAERKIDKNLLPPKKIIGKNSRSLVEKREKDLEVY 95

  Fly    93 LQELLIYFRTELPRALAEFLDFNKYDIIYLLQDLAKLFNESGDALLSSKKEYNLSALEVYAISER 157
            ||:||..|....||.||.||.|:.|:|..:...||:...|.|:.||.:.:.:.:..|::||::|:
Human    96 LQKLLAAFPGVTPRVLAHFLHFHFYEINGITAALAEELFEKGEQLLGAGEVFAIGPLQLYAVTEQ 160

  Fly   158 LSLPCPPSLDRGGKYDFSHVLDFCTQLVALVVTPVKDNASYAQDYNTVDVPIDRSNIIPNRLSFN 222
            |....|.......|.|..|:|||..:|..|.|:..:.             |...|||....|.|:
Human   161 LQQGKPTCASGDAKTDLGHILDFTCRLKYLKVSGTEG-------------PFGTSNIQEQLLPFD 212

  Fly   223 LNAFRNLKTLKFSALSTENIVDIELLKPTLQTICVH--NTTIQNINQVLLCDNLHKHCDVPSLLP 285
            |:.|::|..::.|....::|..:...||||.|:.|.  .|:::.:                 |:|
Human   213 LSIFKSLHQVEISHCDAKHIRGLVASKPTLATLSVRFSATSMKEV-----------------LVP 260

  Fly   286 ETILAS------PSGSGPSTSNGSALVSADAWQEITELDLTGNLLTQIDGSVRTAPKLRRLILDQ 344
            |   ||      |.|   :|..|........||.:|.|||:.|.:::||.||:..||:..|.|..
Human   261 E---ASEFDEWEPEG---TTLEGPVTAVIPTWQALTTLDLSHNSVSEIDESVKLIPKIEFLDLSH 319

  Fly   345 NRIRTVQNLAELPQLQLLSLSGNLIAECVDWHLTMGNLVTLKLAQNKIKTLSGLRKLLSLVNLDL 409
            |.:..|.||..|..|..|.||.|.::.....|..:||:.||.||.|.:::||||.||.|||||||
Human   320 NGLLVVDNLQHLYNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDL 384

  Fly   410 SSNQIEELDEVNHVANLPLLETLRLTGNPLAGSVDYRSRVLARFHERAAEISLDNEPGNQQELDT 474
            ..|:||:::||..:.:||.||.:.|..|||:...|||::|||:|.|||:|:.||:....::||||
Human   385 RDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDYRTKVLAQFGERASEVCLDDTVTTEKELDT 449

  Fly   475 ALVLSALLQSKQ 486
            ..||.|:.::|:
Human   450 VEVLKAIQKAKE 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11807	NP_611017.1	PX_IRAS	8..126	CDD:132785	48/97 (49%)
		PPP1R42	<314..451	CDD:455733	61/136 (45%)
		leucine-rich repeat	315..336	CDD:275380	9/20 (45%)
		leucine-rich repeat	337..381	CDD:275380	13/43 (30%)
		leucine-rich repeat	382..403	CDD:275380	11/20 (55%)
		leucine-rich repeat	404..428	CDD:275380	12/23 (52%)
NISCH	NP_009115.3	Necessary for binding to phosphoinositide-3-P, not sufficient for targeting to endosomes	2..133		50/101 (50%)
		PX_IRAS	14..129	CDD:132785	48/97 (49%)
		Necessary for homooligomerization and targeting to endosomes	120..695		130/378 (34%)
		Interaction with PAK1. /evidence=ECO:0000250	245..869		91/240 (38%)
		LRR	<281..>417	CDD:443914	59/135 (44%)
		leucine-rich repeat	289..311	CDD:275380	9/21 (43%)
		leucine-rich repeat	312..333	CDD:275380	7/20 (35%)
		leucine-rich repeat	334..356	CDD:275380	6/21 (29%)
		leucine-rich repeat	357..378	CDD:275380	11/20 (55%)
		leucine-rich repeat	379..403	CDD:275380	12/23 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	463..501
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	524..547
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	554..573
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	628..687
		Interaction with LIMK. /evidence=ECO:0000250	660..869
		Interaction with ITGA5. /evidence=ECO:0000250	709..807
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1016..1104