DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG11807 and C8orf44-SGK3

DIOPT Version :9

Sequence 1:NP_001260990.1 Gene:CG11807 / 36683 FlyBaseID:FBgn0033996 Length:491 Species:Drosophila melanogaster
Sequence 2:NP_001191102.1 Gene:C8orf44-SGK3 / 100533105 HGNCID:48354 Length:496 Species:Homo sapiens


Alignment Length:447 Identity:96/447 - (21%)
Similarity:167/447 - (37%) Gaps:133/447 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 TVTVPKFSNE--SSSGGVTYYDIKVRVGKVEWLVERRYRDFANLHEKLVGEISISKKLLPPKKLV 74
            :|::|. |:|  ......|.|.:.|.||:.||.|.|||.:|..|:..|..:.......:|.|::.
Human    15 SVSIPS-SDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLKKQFPAMALKIPAKRIF 78

  Fly    75 G-NKQPSFLEQRREQLEIYLQELLIYFRTELPRALAEFLDFNKYDI-IYLLQDLAKLFNESGDAL 137
            | |..|.|::|||..|..::|.|:.|  .||         :|..|: .:|..|..|..::     
Human    79 GDNFDPDFIKQRRAGLNEFIQNLVRY--PEL---------YNHPDVRAFLQMDSPKHQSD----- 127

  Fly   138 LSSKKEYNLSALEVYAISERLSLPCPPSLDRGGK---YDFSHVLDFCTQLVALVVTPVKDNASYA 199
             .|:.|...|:.::::.|:.::|  .||.:...|   :||..|:...:....|:.....|...||
Human   128 -PSEDEDERSSQKLHSTSQNINL--GPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYA 189

  Fly   200 QDYNTVDVPIDRSNIIPNRL-SFNLNAFRN--LKTLK--------FSALSTEN---IVD------ 244
                   |.:.:..|:.||. ..::.|.||  ||.:|        :|..:||.   ::|      
Human   190 -------VKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGE 247

  Fly   245 -----------------------------IELLKPTLQTICVHNTTIQNINQVLLCD-NLHKH-- 277
                                         :..:|...:.:...|..:.::..|:|.| .|.|.  
Human   248 LFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGI 312

  Fly   278 ---------CDVPS-LLPETILASPSGSGPSTSNGSALVSADAW------------------QEI 314
                     |..|. |.||.|...|..:           :.|.|                  :::
Human   313 AISDTTTTFCGTPEYLAPEVIRKQPYDN-----------TVDWWCLGAVLYEMLYGLPPFYCRDV 366

  Fly   315 TEL--DLTGNLLTQIDGSVRTAPKLRRLILD---QNRIRTVQNLAEL---PQLQLLS 363
            .|:  ::....|:...|...||..:...:|:   |||:...::..|:   |..:.||
Human   367 AEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLS 423

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11807NP_001260990.1 PX_IRAS 8..126 CDD:132785 36/117 (31%)
leucine-rich repeat 315..336 CDD:275380 5/22 (23%)
LRR_8 335..414 CDD:290566 8/35 (23%)
leucine-rich repeat 337..381 CDD:275380 8/33 (24%)
LRR_4 381..422 CDD:289563
leucine-rich repeat 382..403 CDD:275380
leucine-rich repeat 404..428 CDD:275380
C8orf44-SGK3NP_001191102.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 2/6 (33%)
PX_CISK 12..120 CDD:132780 36/116 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 121..156 8/42 (19%)
STKc_SGK3 165..490 CDD:270755 48/277 (17%)
Nuclear localization signal. /evidence=ECO:0000250 195..205 3/9 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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