DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11807 and nisch

DIOPT Version :9

Sequence 1:	NP_001260990.1	Gene:	CG11807 / 36683	FlyBaseID:	FBgn0033996	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	XP_031755760.1	Gene:	nisch / 100170568	XenbaseID:	XB-GENE-5968394	Length:	1362	Species:	Xenopus tropicalis

Alignment Length:	471	Identity:	163/471 - (34%)
Similarity:	250/471 - (53%)	Gaps:	44/471 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 TYYDIKVRVGKVEWLVERRYRDFANLHEKLVGEISISKKLLPPKKLVGNKQPSFLEQRREQLEIY 92
            |.|.|::|.|...|.|..||.||.:|||||..|..|.:.||||||::|....|.:|:|::.||:|
Frog    24 TVYIIQLRAGSFHWEVRHRYSDFYDLHEKLTAENKIERNLLPPKKMIGKNSRSLVEKRQKDLELY 88

  Fly    93 LQELLIYFRTELPRALAEFLDFNKYDIIYLLQDLAKLFNESGDALLSSKKEYNLSALEVYAISER 157
            ||.||..|...:|:|||.||.|:.|:|..:...||:.....|:.||.:.:.:.::.|::||:::.
Frog    89 LQTLLGTFPLAVPKALARFLHFHLYEIHGIAAVLAEELFHKGEQLLLAGEVFTVTPLQLYAVTQL 153

  Fly   158 LSLPCPPSLDRGGKYDFSHVLDFCTQLVALVVTPVKDNASYAQDYNTVDVPIDRSNIIPNRLSFN 222
            |....|.......:.|..|::||..:|..|.::....             |:..|||....|..:
Frog   154 LRRAKPTCSTGDARNDLGHIMDFACRLKYLRISGRTG-------------PVGTSNIHEQSLPCD 205

  Fly   223 LNAFRNLKTLKFSALSTENIVDIELLKPTLQTICVHNTTIQNINQVLLCDNLHKHCDVPS----L 283
            |:.|::|..::.|..:...:..:...:.:|.||.:                   ||...|    |
Frog   206 LSIFKSLCQIEVSQCNARLLSGLTSCRRSLATISI-------------------HCSASSMKDIL 251

  Fly   284 LPETI---LASPSGSGPSTSNGSALVS-ADAWQEITELDLTGNLLTQIDGSVRTAPKLRRLILDQ 344
            :||..   ...|.|..|    ||.:.: ...|:.:|.|||:.|.::.||.||:..|::..|....
Frog   252 VPEAYDFEQWEPEGVAP----GSPITAVVPKWKVLTTLDLSHNRISCIDESVKLIPEIEFLDFSH 312

  Fly   345 NRIRTVQNLAELPQLQLLSLSGNLIAECVDWHLTMGNLVTLKLAQNKIKTLSGLRKLLSLVNLDL 409
            |.|.|::||..|..|..|.||.|.:|:....:..:||:.||.||.|.:::|.||.||.|||||||
Frog   313 NDISTIENLQHLYNLIHLDLSYNKLADLTGIYTKVGNIKTLSLAGNVLESLRGLNKLYSLVNLDL 377

  Fly   410 SSNQIEELDEVNHVANLPLLETLRLTGNPLAGSVDYRSRVLARFHERAAEISLDNEPGNQQELDT 474
            |.|:||:|:||.::..||.||.:.|.||||....|||::|||.|.:||:|:.||:....::||||
Frog   378 SQNRIEQLEEVRNIGGLPCLEGVLLAGNPLTVIPDYRTKVLALFGDRASEVCLDSTRTTEKELDT 442

  Fly   475 ALVLSALLQSKQRQQQ 490
            ..||.|:.:|:..:.:
Frog   443 VEVLKAIQKSRDARNK 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11807	NP_001260990.1	PX_IRAS	8..126	CDD:132785	45/97 (46%)
		leucine-rich repeat	315..336	CDD:275380	9/20 (45%)
		LRR_8	335..414	CDD:290566	35/78 (45%)
		leucine-rich repeat	337..381	CDD:275380	13/43 (30%)
		LRR_4	381..422	CDD:289563	25/40 (63%)
		leucine-rich repeat	382..403	CDD:275380	10/20 (50%)
		leucine-rich repeat	404..428	CDD:275380	14/23 (61%)
nisch	XP_031755760.1	PX_IRAS	16..122	CDD:132785	45/97 (46%)
		PPP1R42	<282..419	CDD:411060	62/136 (46%)
		leucine-rich repeat	282..304	CDD:275380	9/21 (43%)
		leucine-rich repeat	305..326	CDD:275380	7/20 (35%)
		leucine-rich repeat	327..349	CDD:275380	6/21 (29%)
		leucine-rich repeat	350..371	CDD:275380	10/20 (50%)
		leucine-rich repeat	372..396	CDD:275380	14/23 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8071
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006271
OrthoInspector	1	1.000	-	-		oto104654
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4560
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.000