DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPHR and gpr89b

DIOPT Version :9

Sequence 1:	NP_611016.2	Gene:	GPHR / 36682	FlyBaseID:	FBgn0033995	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	XP_002940512.1	Gene:	gpr89b / 100490107	XenbaseID:	XB-GENE-484935	Length:	455	Species:	Xenopus tropicalis

Alignment Length:	454	Identity:	262/454 - (57%)
Similarity:	340/454 - (74%)	Gaps:	17/454 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAFLGDCVIVFVSQMIFFAGGWLFFNKELFKHYEIRHISVQLIFSSTFALSITMFELIIFEIIDV 65
            |:||.|.|::.:||::||..|||||.::|||.||:|...||::||.|||.|.||||||||||:.:
Frog     1 MSFLIDSVLMVISQLLFFGFGWLFFMRQLFKDYEVRQYVVQVVFSVTFAFSCTMFELIIFEILGL 65

  Fly    66 LESSSRYFHWRLGLTLLLFMTTAVIPIYICYSVIHSISFFSDKWVRILTTFC--WFIFIYGLWRI 128
            |.||||||||:|.|.::|.:...|:|.||.|.|:.:|.....:  |:|.: |  |..|:|..|::
Frog    66 LNSSSRYFHWKLNLCVILLVLVFVVPFYIGYFVVSNIRLLHRQ--RLLFS-CTVWLTFMYFFWKL 127

  Fly   129 GDPFPLLSASHGIFTIEQGVSRISVIGVTVMAILSGFGAVNYPYTSMSYFIKPVSRNDIICFERR 193
            |||||:||..|||.:|||.:||:.|||||:||:||||||||.|||.||||::.|:..||:..|||
Frog   128 GDPFPILSPKHGILSIEQLISRVGVIGVTLMALLSGFGAVNCPYTYMSYFLRNVTDADILALERR 192

  Fly   194 LALTVEMLSAKKRKIAMAIYN-------HNKLNPSKPRIWDMLASAVQRNTNSGEDINQLKQEVY 251
            |..|::|:.:||::||....|       |:|  ||  ..|.|:.| |..:....|:::|::|||.
Frog   193 LLQTMDMIVSKKKRIAALRRNMFQRGEEHSK--PS--GFWGMIKS-VTSSAPVSENLSQIQQEVD 252

  Fly   252 GLEELLRSVFLELSSLKNMEERQRWSQTLKGKYFNVLGHFFSVYCVYKIFMCCINIIFDRVGRKD 316
            .||||.|.:|||.:.|...:||..:|:|.:|||||.||:|||:|||:||||..|||:|||||:.|
Frog   253 ALEELSRQLFLETADLHATKERIEYSKTFQGKYFNFLGYFFSIYCVWKIFMATINIVFDRVGKTD 317

  Fly   317 PVTRGLEIAIHWCGFNIDFAFWNQHISFLLVGCIVITSIRGLLLTLTKFFYRISSSKSSNIIVLI 381
            |||||:||.:::.|...|..||:|||||:|||.|::|||||||:|||||||.||||||||:|||:
Frog   318 PVTRGIEITVNYLGIQFDVKFWSQHISFILVGIIIVTSIRGLLITLTKFFYAISSSKSSNVIVLL 382

  Fly   382 LGQIMGMYFCSSVLLMRMNMPAEYRVIITEVLGNLHFNFYHRWFDVIFLVSALTTIIVLYLSRK 445
            |.|||||||.|||||:||:||.|||.|||||||.|.|||||||||||||||||::|:.|||:.|
Frog   383 LAQIMGMYFVSSVLLIRMSMPLEYRTIITEVLGELQFNFYHRWFDVIFLVSALSSILFLYLAHK 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPHR	NP_611016.2	GPHR_N	141..208	CDD:289314	39/66 (59%)
GPHR	NP_611016.2	ABA_GPCR	277..443	CDD:289215	121/165 (73%)
gpr89b	XP_002940512.1	GPHR_N	140..207	CDD:372172	39/66 (59%)
gpr89b	XP_002940512.1	ABA_GPCR	276..446	CDD:372104	122/169 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1946
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9475
Inparanoid	1	1.050	474	1.000	Inparanoid score	I1455
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1065554at2759
OrthoFinder	1	1.000	-	-		FOG0003368
OrthoInspector	1	1.000	-	-		oto102323
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4359
SonicParanoid	1	1.000	-	-		X2255
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.090