DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment igl and spa17

DIOPT Version :9

Sequence 1:	NP_477060.1	Gene:	igl / 36681	FlyBaseID:	FBgn0013467	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_001073148.1	Gene:	spa17 / 564082	ZFINID:	ZDB-GENE-061027-337	Length:	660	Species:	Danio rerio

Alignment Length:	267	Identity:	63/267 - (23%)
Similarity:	102/267 - (38%)	Gaps:	54/267 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SQELKTKDGAAMDAVSNGEPEPSAPPLEGESSKSSASNHTNH-------------AKSSSIISNG 57
            |.|:.......:|.:.....:......|.|:..||...:|:.             .|..|.:::.
Zfish   377 SDEIHDSKSEVVDVLDKVHHQCDTRTGEEEAENSSDEENTSKILDALNEEDFLETPKPVSQMNDS 441

  Fly    58 EAKAANGGGAVGGGSGKSEATN--GIDRPCDKAAITEFNDDEDEAKAATKIQAVFRGHKVRETMK 120
            ||:|:|            |..|  ..::..:...:.|.:|.:.:...|.::..     .:...::
Zfish   442 EAEASN------------EILNADAFEKDLNTENVNEGSDLDSDGFEAEEMDL-----DISNVLQ 489

  Fly   121 KSETKTATNNGSAAGAAPSAAAAEAAASAEPTKAEL------------EAEFDPNDKDLCHAALK 173
            .:|.||..:..........|.:....|:.||.:.|.            :.|...||.|. .|.|:
Zfish   490 PNEEKTEDDGNHDPEPEEDAFSEAEQANPEPLENETVVVNEELFESQEQTENTENDVDQ-EAQLE 553

  Fly   174 IQSTFRGHLARKLVNKDAPEDEDI----QEITKKVAEE--LDIDLTDPELNKAATKIQASFRGHK 232
            .|   |..:....:..:..|:.||    :|.::...||  :||.|.|||.||||.||||.||||.
Zfish   554 EQ---RDKIQEMTLESENLENTDISEPKEESSQPQEEEDIMDIPLDDPEANKAAAKIQAGFRGHM 615

  Fly   233 TRKDANP 239
            |||...|
Zfish   616 TRKKMKP 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
igl	NP_477060.1	Adgb_C_mid-like	<74..>129	CDD:412094	8/56 (14%)
		IQ motif	104..122	CDD:412094	0/17 (0%)
		Adgb_C_mid-like	<169..>209	CDD:412094	10/45 (22%)
		IQ	169..185	CDD:197470	4/15 (27%)
		IQ motif	172..189	CDD:412094	3/16 (19%)
		globin helix A	196..209	CDD:412094	5/18 (28%)
		IQ	216..235	CDD:197470	14/18 (78%)
spa17	NP_001073148.1	DD_CABYR_SP17	12..50	CDD:213047
spa17	NP_001073148.1	IQ	599..621	CDD:197470	16/21 (76%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106874
Panther	1	1.100	-	-	LDO	PTHR10699
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8834
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.900