DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment igl and spa17

DIOPT Version :9

Sequence 1:	NP_477060.1	Gene:	igl / 36681	FlyBaseID:	FBgn0013467	Length:	240	Species:	Drosophila melanogaster
Sequence 2:	NP_001006758.1	Gene:	spa17 / 448437	XenbaseID:	XB-GENE-958602	Length:	495	Species:	Xenopus tropicalis

Alignment Length:	334	Identity:	78/334 - (23%)
Similarity:	111/334 - (33%)	Gaps:	104/334 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GCNTSQELKTKDGAAMDAVSNGEP---------EPSAPPLEGESSK--SSASNHTNH-------- 47
            |.|...::|....:.:|.....||         |.....:|.|..:  |.|.|:..|
Frog   139 GYNVRHKVKIHQESFVDNYMKPEPEHEDTDQAKETKCDLMENEDCEFNSKADNNEMHDEKVEIPD 203

  Fly    48 -------AKS----SSIISNGEA-KAANGGGAVGG----GSGKSEATNG--IDRPCDKAAITEFN 94
                   .||    .:|..:||. :..|..|..|.    .|.|.|.:.|  :||......::|..
Frog   204 SISADELVKSEEFQEAITDSGEKDEEINLVGREGKEREFNSLKPEGSGGQEVDRQEQFTEVSELE 268

  Fly    95 ----DD---EDEAKAATKIQAVFRGHKVRE-----TMKKSETKTATN------------------ 129
                ||   .|..|.||..:...|.:.|.|     |.|:.||....|
Frog   269 IKEPDDSMQNDTIKDATSEEKEERINDVVEHYMITTGKRGETTQDDNLSDLTDQSATYEIQNTEV 333

  Fly   130 NGSAAGAAPSAAAAEA------------AASAEPT-------------------KAELEAEFDPN 163
            |.:.....|....::.            .:|.||.                   .:::|......
Frog   334 NTTNESILPDLLYSQTNELESSSNQLLDTSSKEPNPLADSNIDILNEQSSVHIDTSDMENLSGKP 398

  Fly   164 DKDLCHAALKI--QSTFRGHLARKLVNKDAPEDEDIQEITKKVAEELDIDLTDPELNKAATKIQA 226
            |.:|.|..::.  ..|...|..|.  |.::|::.  :...|...|.|||.|.||:.|.||.||||
Frog   399 DPELLHNIMESLGNQTVLEHEDRS--NLESPKEN--ESFRKPQEEALDIPLDDPDANAAAAKIQA 459

  Fly   227 SFRGHKTRK 235
            .||||.|||
Frog   460 GFRGHMTRK 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
igl	NP_477060.1	Adgb_C_mid-like	<74..>129	CDD:412094	19/68 (28%)
		IQ motif	104..122	CDD:412094	6/22 (27%)
		Adgb_C_mid-like	<169..>209	CDD:412094	8/41 (20%)
		IQ	169..185	CDD:197470	3/17 (18%)
		IQ motif	172..189	CDD:412094	3/18 (17%)
		globin helix A	196..209	CDD:412094	2/12 (17%)
		IQ	216..235	CDD:197470	12/18 (67%)
spa17	NP_001006758.1	DD_CABYR_SP17	12..50	CDD:213047
spa17	NP_001006758.1	MDN1	<159..488	CDD:331582	74/314 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10699
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8834
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.040