DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7544 and METTL16

DIOPT Version :9

Sequence 1:	NP_001163156.1	Gene:	CG7544 / 36680	FlyBaseID:	FBgn0033994	Length:	305	Species:	Drosophila melanogaster
Sequence 2:	NP_076991.3	Gene:	METTL16 / 79066	HGNCID:	28484	Length:	562	Species:	Homo sapiens

Alignment Length:	292	Identity:	129/292 - (44%)
Similarity:	189/292 - (64%)	Gaps:	12/292 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MHPRNVLRTQ-PDYTKMAIKYKDFRQQCQLELNGKVSVNFRNEKTLRELTKMLLKEYYDLDVDFA 76
            ||.||..:.: ||:..:|.||.||:|..|:.|||:||:||::.:.:|.||..||:|.:.|.:|..
Human     7 MHARNRYKDKPPDFAYLASKYPDFKQHVQINLNGRVSLNFKDPEAVRALTCTLLREDFGLSIDIP 71

  Fly    77 PGSLVPTLALRLNYILWLEDLM-----EPLNLQNIRGIDIGCGSSCIYSLLGAKKNGWHMLALES 136
            ...|:||:.||||||.|:|||:     :...|:  ||||||.|:||||.||||..|||:.||.|.
Human    72 LERLIPTVPLRLNYIHWVEDLIGHQDSDKSTLR--RGIDIGTGASCIYPLLGATLNGWYFLATEV 134

  Fly   137 KPQNIEYAKENVKRNHMESLIEVYAQPDNTNIFKSYFEQDQQQLQYQFCLCNPPFFDSNLPNPLG 201
            ......|||:||::|::..||:|...|..|.:..:.  :::.::.|.||:||||||.:.| ...|
Human   135 DDMCFNYAKKNVEQNNLSDLIKVVKVPQKTLLMDAL--KEESEIIYDFCMCNPPFFANQL-EAKG 196

  Fly   202 GNTRNPERRPAPNNARTGSQEELTCVGGEVQFVQRIIDESLENKERVRIFTTMLGVKANVPRILD 266
            .|:||| |||.|::..||...|:...|||::||:|||.:||:.|:|:|.::.|||.|.::..:.:
Human   197 VNSRNP-RRPPPSSVNTGGITEIMAEGGELEFVKRIIHDSLQLKKRLRWYSCMLGKKCSLAPLKE 260

  Fly   267 YLKELQVANVSTTEFHQGHTTRWAVAWSFHSE 298
            .|:...|..|:.|||.||.|.|||:||||:.:
Human   261 ELRIQGVPKVTYTEFCQGRTMRWALAWSFYDD 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7544	NP_001163156.1	AdoMet_MTases	45..295	CDD:302624	112/254 (44%)
METTL16	NP_076991.3	RNA-binding. /evidence=ECO:0000269\|PubMed:30197297, ECO:0007744\|PDB:6DU4, ECO:0007744\|PDB:6DU5	17..20		1/2 (50%)
		Methyltransf_10	40..291	CDD:283594	114/256 (45%)
		K-loop. /evidence=ECO:0000269\|PubMed:30197297	163..167		1/3 (33%)
		RNA-binding. /evidence=ECO:0000269\|PubMed:30197297, ECO:0007744\|PDB:6DU4, ECO:0007744\|PDB:6DU5	199..211		7/12 (58%)
		RNA-binding. /evidence=ECO:0000269\|PubMed:30197297, ECO:0007744\|PDB:6DU4, ECO:0007744\|PDB:6DU5	250..254		2/3 (67%)
		RNA-binding. /evidence=ECO:0000269\|PubMed:30197297, ECO:0007744\|PDB:6DU4, ECO:0007744\|PDB:6DU5	277..283		3/5 (60%)
		VCR 1. /evidence=ECO:0000269\|PubMed:28525753	289..400		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..498
		VCR 2. /evidence=ECO:0000269\|PubMed:28525753	514..562
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157817
Domainoid	1	1.000	241	1.000	Domainoid score	I2251
eggNOG	1	0.900	-	-		E1_COG3129
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34653
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3338
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48748
OrthoDB	1	1.010	-	-		D1358504at2759
OrthoFinder	1	1.000	-	-		FOG0004817
OrthoInspector	1	1.000	-	-		oto91214
orthoMCL	1	0.900	-	-		OOG6_102749
Panther	1	1.100	-	-	LDO	PTHR13393
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3398
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770