DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7544 and Mettl16

DIOPT Version :9

Sequence 1:	NP_001163156.1	Gene:	CG7544 / 36680	FlyBaseID:	FBgn0033994	Length:	305	Species:	Drosophila melanogaster
Sequence 2:	NP_080473.1	Gene:	Mettl16 / 67493	MGIID:	1914743	Length:	553	Species:	Mus musculus

Alignment Length:	292	Identity:	128/292 - (43%)
Similarity:	188/292 - (64%)	Gaps:	12/292 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MHPRNVLRTQ-PDYTKMAIKYKDFRQQCQLELNGKVSVNFRNEKTLRELTKMLLKEYYDLDVDFA 76
            ||.||..:.: ||:..:|.||.||:|..|:.|||:||:||::.:.:|.||..||:|.:.|.:|..
Mouse     7 MHARNRYKDKPPDFAYLASKYPDFKQHIQINLNGRVSLNFKDPEAVRALTCTLLREDFGLSIDIP 71

  Fly    77 PGSLVPTLALRLNYILWLEDLM-----EPLNLQNIRGIDIGCGSSCIYSLLGAKKNGWHMLALES 136
            ...|:||:.||||||.|:|||:     :...|:  ||||||.|:||||.||||..|||:.||.|.
Mouse    72 LERLIPTVPLRLNYIHWVEDLIGHQDSDKTTLR--RGIDIGTGASCIYPLLGATLNGWYFLATEV 134

  Fly   137 KPQNIEYAKENVKRNHMESLIEVYAQPDNTNIFKSYFEQDQQQLQYQFCLCNPPFFDSNLPNPLG 201
            ......|||:||::|::..||:|...|..|.:..:.  :::.::.|.||:||||||.:.| ...|
Mouse   135 DDMCFNYAKKNVEQNNLSDLIKVVKVPQKTLLMDAL--KEESEIVYDFCMCNPPFFANQL-EAKG 196

  Fly   202 GNTRNPERRPAPNNARTGSQEELTCVGGEVQFVQRIIDESLENKERVRIFTTMLGVKANVPRILD 266
            .|:|| .|||.|::..||...|:...|||::||:|||.:||:.|:|:|.::.|||.|.::..:.:
Mouse   197 VNSRN-SRRPPPSSVNTGGITEIMAEGGELEFVKRIIHDSLQLKKRLRWYSCMLGKKCSLAPLKE 260

  Fly   267 YLKELQVANVSTTEFHQGHTTRWAVAWSFHSE 298
            .|:...|..|:.|||.||.|.|||:||||:.:
Mouse   261 ELRIQGVPKVTFTEFCQGRTMRWALAWSFYDD 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7544	NP_001163156.1	AdoMet_MTases	45..295	CDD:302624	111/254 (44%)
Mettl16	NP_080473.1	AdoMet_MTases	1..291	CDD:388410	128/289 (44%)
		RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q86W50	17..20		1/2 (50%)
		K-loop. /evidence=ECO:0000250\|UniProtKB:Q86W50	163..167		1/3 (33%)
		RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q86W50	199..211		6/12 (50%)
		RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q86W50	250..254		2/3 (67%)
		RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q86W50	277..283		3/5 (60%)
		VCR 1. /evidence=ECO:0000250\|UniProtKB:Q86W50	289..400		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..496
		VCR 2. /evidence=ECO:0000250\|UniProtKB:Q86W50	506..553
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848204
Domainoid	1	1.000	239	1.000	Domainoid score	I2287
eggNOG	1	0.900	-	-		E1_COG3129
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34653
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3346
Isobase	1	0.950	-	0	Normalized mean entropy	S5435
OMA	1	1.010	-	-		QHG48748
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004817
OrthoInspector	1	1.000	-	-		oto94796
orthoMCL	1	0.900	-	-		OOG6_102749
Panther	1	1.100	-	-	LDO	PTHR13393
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4658
SonicParanoid	1	1.000	-	-		X3398
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740