DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7544 and mettl16

DIOPT Version :9

Sequence 1:	NP_001163156.1	Gene:	CG7544 / 36680	FlyBaseID:	FBgn0033994	Length:	305	Species:	Drosophila melanogaster
Sequence 2:	NP_001003611.1	Gene:	mettl16 / 445217	ZFINID:	ZDB-GENE-040801-130	Length:	471	Species:	Danio rerio

Alignment Length:	288	Identity:	129/288 - (44%)
Similarity:	185/288 - (64%)	Gaps:	9/288 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MHPRNVLRTQ-PDYTKMAIKYKDFRQQCQLELNGKVSVNFRNEKTLRELTKMLLKEYYDLDVDFA 76
            |||||..:.: ||:..:|.||.:|::..|..|.|:|::||::.:.:|.||..||||.:.|.::..
Zfish     7 MHPRNRYKDKPPDFVYLASKYPEFQKHVQTTLTGRVTLNFKDPEAVRALTCTLLKEDFGLTIEIP 71

  Fly    77 PGSLVPTLALRLNYILWLEDLMEPL-NLQNIRGIDIGCGSSCIYSLLGAKKNGWHMLALESKPQN 140
            ...|:||:.||||||.|:|||:... |.|  ||||||.|:||||.||||..|||..||.|.....
Zfish    72 LERLIPTVPLRLNYIHWVEDLIGGQGNPQ--RGIDIGTGASCIYPLLGATMNGWFFLATEVDDIC 134

  Fly   141 IEYAKENVKRNHMESLIEVYAQPDNTNIFKSYFEQDQQQLQYQFCLCNPPFFDSNLPNPLGGNTR 205
            ..|||:||::||:..||:|...|..|.:..:..|   :.:.|.||:||||||.:.| ...|.|:|
Zfish   135 FNYAKKNVEQNHLAELIKVVKVPQKTLLMDALKE---ESIVYDFCMCNPPFFANQL-EAKGVNSR 195

  Fly   206 NPERRPAPNNARTGSQEELTCVGGEVQFVQRIIDESLENKERVRIFTTMLGVKANVPRILDYLKE 270
            | .|||.|::..||...|:...|||::||:|:|.:||:.|:|:|.::.|||.|.::..:.|.|::
Zfish   196 N-SRRPPPSSINTGGVTEIMAEGGELEFVKRVIHDSLQLKKRLRWYSCMLGKKCSLAPLKDELRK 259

  Fly   271 LQVANVSTTEFHQGHTTRWAVAWSFHSE 298
            ..||.|:.|||.||.|.|||:||||:.:
Zfish   260 QGVAKVTHTEFCQGRTMRWALAWSFYDD 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7544	NP_001163156.1	AdoMet_MTases	45..295	CDD:302624	114/250 (46%)
mettl16	NP_001003611.1	RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q86W50	17..20		1/2 (50%)
		AdoMet_MTases	40..286	CDD:302624	116/252 (46%)
		K-loop. /evidence=ECO:0000250\|UniProtKB:Q86W50	159..163		1/3 (33%)
		RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q86W50	194..206		6/12 (50%)
		RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q86W50	245..249		2/3 (67%)
		RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q86W50	272..278		3/5 (60%)
		VCR 1. /evidence=ECO:0000250\|UniProtKB:Q86W50	284..390		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	375..412
		VCR 2. /evidence=ECO:0000250\|UniProtKB:Q86W50	421..470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593608
Domainoid	1	1.000	236	1.000	Domainoid score	I2282
eggNOG	1	0.900	-	-		E1_COG3129
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34653
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3352
OMA	1	1.010	-	-		QHG48748
OrthoDB	1	1.010	-	-		D1358504at2759
OrthoFinder	1	1.000	-	-		FOG0004817
OrthoInspector	1	1.000	-	-		oto39286
orthoMCL	1	0.900	-	-		OOG6_102749
Panther	1	1.100	-	-	LDO	PTHR13393
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4658
SonicParanoid	1	1.000	-	-		X3398
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800