DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8089 and ZNF276

DIOPT Version :9

Sequence 1:	NP_611014.1	Gene:	CG8089 / 36679	FlyBaseID:	FBgn0033993	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_001106997.1	Gene:	ZNF276 / 92822	HGNCID:	23330	Length:	614	Species:	Homo sapiens

Alignment Length:	326	Identity:	63/326 - (19%)
Similarity:	108/326 - (33%)	Gaps:	121/326 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 SQEEKELELSLNKVEDILVPVAEDLQSYFKDESKHPIQKRKTSSLSKCPSCAQNYGFSFSHQLHM 306
            |::|.:.:.:....::...|..|...|..|.|||. .:|.:...:.|.|.....:
Human   366 SEDENDKKQNAQSSDESFEPYPERKVSGKKSESKE-AKKSEEPRIRKKPGPKPGW---------- 419

  Fly   307 VKHRRERLYTNFPFHCSFCNRSFLTRKFLRKHQQRVRTFSTLLYRPFKCPH--CTWRFQLKSALD 369
                                     :|.||..::.:.|.       :|||:  ||..::....:.
Human   420 -------------------------KKKLRCEREELPTI-------YKCPYQGCTAVYRGADGMK 452

  Fly   370 SHVLRIHE--RRKPCLICKLPTSRLCCSAHTSKECNRAMQKYRDKMRPLREPPKGGCRKQPTPVC 432
            .|:...||  |.:||                                     |..|
Human   453 KHIKEHHEEVRERPC-------------------------------------PHPG--------- 471

  Fly   433 KICNRKFTRKFFLEEHMNKAHLNKRNFTCEICGANFYSQGTMQTHRKAVHLLVH--------TVQ 489
              ||:.|....:|:.|:...|...||:.|:.||         ||.::..|||||        .:|
Human   472 --CNKVFMIDRYLQRHVKLIHTEVRNYICDECG---------QTFKQRKHLLVHQMRHSGAKPLQ 525

  Fly   490 CEVCDLTIKSKGNYRRHC---KSQSHKDNLV-KFGKNNDKTKDSNRRKG-----ARTTDEKLDIE 545
            ||||....:.:.:.:.|.   |:::..|... :.|:..:|..:.|....     .:|.|:.|.:|
Human   526 CEVCGFQCRQRASLKYHMTKHKAETELDFACDQCGRRFEKAHNLNVHMSMVHPLTQTQDKALPLE 590

  Fly   546 A 546
            |
Human   591 A 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8089	NP_611014.1	C2H2 Zn finger	289..309	CDD:275368	1/19 (5%)
		C2H2 Zn finger	322..343	CDD:275368	3/20 (15%)
		C2H2 Zn finger	355..376	CDD:275368	5/22 (23%)
		C2H2 Zn finger	432..453	CDD:275368	5/20 (25%)
		C2H2 Zn finger	461..486	CDD:275368	8/24 (33%)
		C2H2 Zn finger	490..506	CDD:275368	4/15 (27%)
ZNF276	NP_001106997.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		zf-AD	79..155	CDD:285071
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	268..420		12/89 (13%)
		C2H2 Zn finger	470..490	CDD:275368	6/30 (20%)
		zf-C2H2	496..518	CDD:278523	10/30 (33%)
		C2H2 Zn finger	498..518	CDD:275368	10/28 (36%)
		C2H2 Zn finger	526..546	CDD:275368	5/19 (26%)
		C2H2 Zn finger	556..573	CDD:275368	3/16 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..614		4/9 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24406
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100