DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8089 and ZNF160

DIOPT Version :9

Sequence 1:	NP_611014.1	Gene:	CG8089 / 36679	FlyBaseID:	FBgn0033993	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_001096073.1	Gene:	ZNF160 / 90338	HGNCID:	12948	Length:	818	Species:	Homo sapiens

Alignment Length:	616	Identity:	120/616 - (19%)
Similarity:	207/616 - (33%)	Gaps:	167/616 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GKLLVTYENFTTDLPVLSIDKKPYGC------------------------PASCHCKCKCCRGFR 45
            ||......|.|:...:.| .:|||.|                        |..||   :|.:.||
Human   263 GKAFTQNSNLTSHRRIHS-GEKPYKCSECGKTFTVRSNLTIHQVIHTGEKPYKCH---ECGKVFR 323

  Fly    46 -EKYV--------------------AFNGE-----------GETIFGTDFSSEL----------- 67
             ..|:                    ||.|.           ||..|..:...:|
Human   324 HNSYLATHRRIHTGEKPYKCNECGKAFRGHSNLTTHQLIHTGEKPFKCNECGKLFTQNSHLISHW 388

  Fly    68 ----------CEDVQKIMRFRSSDMLLLLRTAQLRDN-FWTNEYFKADLQDDFRAIFDAFEEKNR 121
                      |.:..|....|||  |.:.:|....:. :..||..|.     ||  ::::..::|
Human   389 RIHTGEKPYKCNECGKAFSVRSS--LAIHQTIHTGEKPYKCNECGKV-----FR--YNSYLGRHR 444

  Fly   122 KVQLEKLAAILDTVSSGYRRSVSQLAGQEAHGALRPKIAALFLPGLRCDCYKCENLPWKKLQDVE 186
            :|...:.....:.....:....:....|..|...:|           ..|.:|..: :.:...:.
Human   445 RVHTGEKPYKCNECGKAFSMHSNLATHQVIHTGTKP-----------FKCNECSKV-FTQNSQLA 497

  Fly   187 DHQKTHRYSDNFHCQICYRRFYLQHSLTSHIIRKSTSSRELHENKRYKRLLENQKSQEEK----- 246
            :|::.|.....:.|..|.:.|.::.|||:|        :.:|..::..:.:|..||..:|
Human   498 NHRRIHTGEKPYKCNECGKAFSVRSSLTTH--------QAIHSGEKPYKCIECGKSFTQKSHLRS 554

  Fly   247 -------ELELSLNKVEDILVPVAEDLQSYFKDESKHPIQKRKTSSLSKCPSCAQNYGFSFSHQL 304
                   |.....|:...:....::..:.:.....:.|.         ||..|.:.:....|...
Human   555 HRGIHSGEKPYKCNECGKVFAQTSQLARHWRVHTGEKPY---------KCNDCGRAFSDRSSLTF 610

  Fly   305 HMVKHRRERLYTNFPFHCSFCNRSFLTRKFLRKHQQRVRTFSTLLYRPFKCPHCTWRFQLKSALD 369
            |...|..|:     |:.|..|.:.|....:|..| :|:.|..    :|:||..|...|.:.|.|.
Human   611 HQAIHTGEK-----PYKCHECGKVFRHNSYLATH-RRIHTGE----KPYKCNECGKAFSMHSNLT 665

  Fly   370 SHVLRIHERRKP--CLIC-KLPTSRLCCS----AHTSK------ECNRAMQKYRDKMRPLREPPK 421
            :|.: ||...||  |..| |:.|.....:    .||.:      ||.:|. ..|..:...:....
Human   666 THKV-IHTGEKPYKCNQCGKVFTQNSHLANHQRTHTGEKPYRCNECGKAF-SVRSSLTTHQAIHT 728

  Fly   422 GGCRKQPTPVCKICNRKFTRKFFLEEHMNKAHLNKRNFTCEICGANFYSQGTMQTHRKAVHLLVH 486
            |   |:|.. |..|.:.||:...|..| .:.|..::.:.|..||..|..:.::.|| .|:|....
Human   729 G---KKPYK-CNECGKVFTQNAHLANH-RRIHTGEKPYRCTECGKAFRVRSSLTTH-MAIHTGEK 787

  Fly   487 TVQCEVCDLTIKSKGN----YRRHCKSQSHK 513
            ..:|..|....:...|    :|.|...:.:|
Human   788 RYKCNECGKVFRQSSNLASHHRMHTGEKPYK 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8089	NP_611014.1	C2H2 Zn finger	289..309	CDD:275368	4/19 (21%)
		C2H2 Zn finger	322..343	CDD:275368	6/20 (30%)
		C2H2 Zn finger	355..376	CDD:275368	6/20 (30%)
		C2H2 Zn finger	432..453	CDD:275368	6/20 (30%)
		C2H2 Zn finger	461..486	CDD:275368	8/24 (33%)
		C2H2 Zn finger	490..506	CDD:275368	4/19 (21%)
ZNF160	NP_001096073.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		zf-C2H2	257..279	CDD:278523	4/15 (27%)
		C2H2 Zn finger	259..279	CDD:275368	4/15 (27%)
		zf-H2C2_2	271..295	CDD:290200	7/24 (29%)
		C2H2 Zn finger	287..307	CDD:275368	1/19 (5%)
		zf-H2C2_2	299..324	CDD:290200	5/27 (19%)
		C2H2 Zn finger	315..335	CDD:275368	6/22 (27%)
		zf-H2C2_2	327..350	CDD:290200	1/22 (5%)
		C2H2 Zn finger	343..363	CDD:275368	3/19 (16%)
		zf-H2C2_2	355..380	CDD:290200	4/24 (17%)
		COG5048	367..810	CDD:227381	96/498 (19%)
		C2H2 Zn finger	371..391	CDD:275368	1/19 (5%)
		C2H2 Zn finger	399..419	CDD:275368	7/21 (33%)
		zf-H2C2_2	411..436	CDD:290200	8/33 (24%)
		C2H2 Zn finger	427..447	CDD:275368	6/26 (23%)
		zf-H2C2_2	439..463	CDD:290200	2/23 (9%)
		C2H2 Zn finger	455..475	CDD:275368	1/19 (5%)
		C2H2 Zn finger	483..503	CDD:275368	3/20 (15%)
		zf-H2C2_2	496..519	CDD:290200	4/22 (18%)
		C2H2 Zn finger	511..531	CDD:275368	7/27 (26%)
		zf-H2C2_2	523..548	CDD:290200	8/32 (25%)
		C2H2 Zn finger	539..559	CDD:275368	4/19 (21%)
		zf-H2C2_2	551..576	CDD:290200	2/24 (8%)
		C2H2 Zn finger	567..587	CDD:275368	1/19 (5%)
		C2H2 Zn finger	595..615	CDD:275368	4/19 (21%)
		zf-H2C2_2	607..632	CDD:290200	8/29 (28%)
		C2H2 Zn finger	623..643	CDD:275368	6/20 (30%)
		zf-H2C2_2	635..659	CDD:290200	8/28 (29%)
		C2H2 Zn finger	651..671	CDD:275368	6/20 (30%)
		zf-H2C2_2	663..688	CDD:290200	9/25 (36%)
		C2H2 Zn finger	679..699	CDD:275368	4/19 (21%)
		zf-H2C2_2	691..715	CDD:290200	5/24 (21%)
		C2H2 Zn finger	707..727	CDD:275368	4/20 (20%)
		zf-H2C2_2	719..744	CDD:290200	6/28 (21%)
		C2H2 Zn finger	735..755	CDD:275368	6/20 (30%)
		zf-H2C2_2	747..770	CDD:290200	6/23 (26%)
		C2H2 Zn finger	763..783	CDD:275368	7/20 (35%)
		zf-H2C2_2	775..800	CDD:290200	6/25 (24%)
		C2H2 Zn finger	791..811	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142350
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930