DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8089 and ZNF665

DIOPT Version :9

Sequence 1:	NP_611014.1	Gene:	CG8089 / 36679	FlyBaseID:	FBgn0033993	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_001340387.1	Gene:	ZNF665 / 79788	HGNCID:	25885	Length:	706	Species:	Homo sapiens

Alignment Length:	730	Identity:	145/730 - (19%)
Similarity:	230/730 - (31%)	Gaps:	231/730 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLVTYENFTTDLPVLSIDKKPYGCPASCHCKCKCC------RGFREKYVAFNGEGETIFGTDFSS 65
            :|..|.|      ::|:|           ..|||.      :|       .|..||..:
Human    65 MLENYRN------LVSLD-----------ISCKCVNTDLPPKG-------KNNMGEAFY------ 99

  Fly    66 ELCEDVQKIMRFRSSDML-LLLRTAQLRDNFWTNEY-FKADLQDD---FRAIFDAFEEK--NRKV 123
                 ..|:.|..|.|.: |..:..|      .|.| |:...:||   ::.:....:|.  .|:.
Human   100 -----TVKLERLESCDTVGLSFQEVQ------KNTYDFECQWKDDEGNYKTVLMLQKENLPGRRA 153

  Fly   124 QLEKLAA----ILDTVSSGYRRSVSQLAGQEAHGALRPKIAALFLPGLRCDCYKCENL--PWKKL 182
            |.::.||    |.:.:...::..:.:|...:..|.:.........|..|...|||:..  .:.:.
Human   154 QRDRRAAGNRHIENQLGVSFQSHLPELQQFQHEGKIYEYNQVEKSPNNRGKHYKCDECGKVFSQN 218

  Fly   183 QDVEDHQKTHRYSDNFHCQICYRRFYLQHSLTSHIIRKSTSSRELHE-NKRYK------------ 234
            ..:..|::.|.....:.|..|.:.|.::.:||.|.:        :|. .|.||
Human   219 SRLTSHKRIHTGEKPYQCNKCGKAFTVRSNLTIHQV--------IHTGEKPYKCNECGKVFSQPS 275

  Fly   235 RLLENQKSQE-EKELELSLNKVEDILVPVAEDLQSYFKDESK-------HPIQKRKTSSLSKCPS 291
            .|..:|:... ||..:             ..:....|:..||       |..:|.     .||..
Human   276 NLAGHQRIHTGEKPYK-------------CNECGKAFRAHSKLTTHQVIHTGEKP-----YKCKE 322

  Fly   292 CAQNYGFSFSHQLHMVKHRRERLYT-NFPFHCSFCNRSFLTRKFLRKHQ---------------- 339
            |    |..|:...|:..||  |::| ..|:.|:.|.::|..|..|..||
Human   323 C----GKCFTQNSHLASHR--RIHTGEKPYKCNECGKAFSVRSSLTTHQTIHTGEKPYKCNECGK 381

  Fly   340 -----------QRVRTFSTLLYRPFKCPHCTWRFQLKSALDSHVLRIHERRKP--CLIC------ 385
                       :|:.|..    :|:||..|...|.:.|.|..|.: ||...||  |..|
Human   382 VFRHNSYLAKHRRIHTGE----KPYKCNECGKAFSMHSNLTKHQI-IHTGEKPFKCNECVKVFTQ 441

  Fly   386 --KLPTSRLCCSAHTSK------ECNRAM---------QKYRDKMRPLREPPKGGCRKQPTPVCK 433
              .|...|   ..||.:      ||.:|.         |......:|.:              |.
Human   442 YSHLANHR---RIHTGEKPYRCDECGKAFSVRSSLTTHQAIHTGEKPYK--------------CN 489

  Fly   434 ICNRKFTRKFFLEEHMNKAHLNKRNFTCEICGANFYSQGTMQTHRKAVHLLVHT----VQCEVCD 494
            .|.:.||:...|..|.. .|..::.:.|:.||..|     .||.:.|.|..|||    .:|..|.
Human   490 DCGKVFTQNSHLASHRG-IHSGEKPYKCDECGKAF-----SQTSQLARHWRVHTGEKPYKCNECG 548

  Fly   495 LTIKSKGNYRRHCKSQSHKDNLVKFGKNNDKTKDSN---RRKGARTTDEKLDI-EASSSTNTC-- 553
            .......:...|        ..:..|:...|..|..   |........:::.. |.....|.|
Human   549 KAFSVHSSLTIH--------QTIHTGQKPYKCNDCGKVFRHNSYLAIHQRIHTGEKPYKCNECGK 605

  Fly   554 --MTSANKSTHNYKKMGIK-----------TKQTHLKTPCRSKKRVKIKICETCG------NSIV 599
              ...:|.:||.....|.|           |:.:||....|.....|...|..||      :::.
Human   606 AFSVHSNLATHQVIHTGEKPYKCNECGKVFTQNSHLANHRRIHTGEKPYRCNECGKAFSVRSTLT 670

  Fly   600 GSMQRHYRSMKHKLN 614
            ..|..|.....:|.|
Human   671 THMAVHTGDKPYKCN 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8089	NP_611014.1	C2H2 Zn finger	289..309	CDD:275368	5/19 (26%)
		C2H2 Zn finger	322..343	CDD:275368	8/47 (17%)
		C2H2 Zn finger	355..376	CDD:275368	6/20 (30%)
		C2H2 Zn finger	432..453	CDD:275368	6/20 (30%)
		C2H2 Zn finger	461..486	CDD:275368	8/24 (33%)
		C2H2 Zn finger	490..506	CDD:275368	2/15 (13%)
ZNF665	NP_001340387.1	KRAB	37..76	CDD:307490	4/16 (25%)
		COG5048	192..580	CDD:227381	93/455 (20%)
		C2H2 Zn finger	208..228	CDD:275368	2/19 (11%)
		C2H2 Zn finger	236..256	CDD:275368	6/27 (22%)
		C2H2 Zn finger	264..284	CDD:275368	2/19 (11%)
		C2H2 Zn finger	292..312	CDD:275368	3/19 (16%)
		C2H2 Zn finger	320..340	CDD:275368	8/25 (32%)
		C2H2 Zn finger	348..368	CDD:275368	7/19 (37%)
		C2H2 Zn finger	376..396	CDD:275368	1/19 (5%)
		C2H2 Zn finger	404..424	CDD:275368	6/20 (30%)
		C2H2 Zn finger	432..452	CDD:275368	4/22 (18%)
		C2H2 Zn finger	460..480	CDD:275368	4/19 (21%)
		C2H2 Zn finger	488..508	CDD:275368	6/20 (30%)
		C2H2 Zn finger	516..536	CDD:275368	8/24 (33%)
		C2H2 Zn finger	544..564	CDD:275368	3/27 (11%)
		C2H2 Zn finger	572..592	CDD:275368	2/19 (11%)
		zf-H2C2_2	584..608	CDD:316026	3/23 (13%)
		C2H2 Zn finger	600..620	CDD:275368	5/19 (26%)
		zf-H2C2_2	612..637	CDD:316026	5/24 (21%)
		C2H2 Zn finger	628..648	CDD:275368	4/19 (21%)
		zf-H2C2_2	640..664	CDD:316026	7/23 (30%)
		C2H2 Zn finger	656..676	CDD:275368	4/19 (21%)
		zf-H2C2_2	669..693	CDD:316026	4/17 (24%)
		C2H2 Zn finger	684..704	CDD:275368	1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142351
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930