DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8089 and ZNF99

DIOPT Version :9

Sequence 1:	NP_611014.1	Gene:	CG8089 / 36679	FlyBaseID:	FBgn0033993	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_001073878.2	Gene:	ZNF99 / 7652	HGNCID:	13175	Length:	864	Species:	Homo sapiens

Alignment Length:	643	Identity:	135/643 - (20%)
Similarity:	214/643 - (33%)	Gaps:	215/643 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VLSIDKKPY---GCP-----ASCHCKCKCCRGFREKYVAFNGEGETIFGTDFSSELCEDVQKIMR 76
            ::..:.|||   .|.     :|...|||                  |..|......||:..|:
Human   221 IIHTEDKPYKYKKCGKAFNISSMFTKCK------------------IIHTGKKPCKCEECGKV-- 265

  Fly    77 FRSSDMLLLLRTAQLRDNFWTNEYFKADLQDDFRAIFDAFEEKNRKVQLEKLAAILDTVSSGYRR 141
            |.:|..|:                                  |::.:...|.....:.....:::
Human   266 FNNSSTLM----------------------------------KHKIIHTGKKPYKCEECGKAFKQ 296

  Fly   142 SVSQLAGQEA-HGALRPKIAALFLPGLRCDCYKCENL--PWKKLQDVEDHQKTHRYSDNFHCQIC 203
            | |.|...:| |...:|              ||||..  .:.....:..||..|.....:.|:.|
Human   297 S-SHLTRHKAIHTGEKP--------------YKCEECGKAFNHFSALRKHQIIHTGKKPYKCEEC 346

  Fly   204 YRRFYLQHSLTSHIIRKSTSSRELH-ENKRYKRLLENQKSQEEKELELSLNKVEDILVPVAEDLQ 267
            .:.|....:|..|.|        :| |.|.||        .||.....|             :|.
Human   347 GKAFSQSSTLRKHEI--------IHTEEKPYK--------YEECGKAFS-------------NLS 382

  Fly   268 SYFKDESKHPIQKRKTSSLSKCPSCAQNYGFSFSHQLHMVKHRRERLYTNFPFHCSFCNRSFLTR 332
            :..|.|..|..||.     .||..|.:.:.:|....:|.|.|..|:     |..|..|.::|...
Human   383 ALRKHEIIHTGQKP-----YKCEECGKAFKWSSKLTVHKVIHTAEK-----PCKCEECGKAFKRF 437

  Fly   333 KFLRKHQQRVRTFSTLLY---RPFKCPHCTWRFQLKSALDSHVLRIHERRKPCLICKLPTSRLCC 394
            ..||||:        :::   :|:||..|:..|...|||..|.: ||...||
Human   438 SALRKHK--------IIHTGKQPYKCEECSKAFSNFSALRKHEI-IHTGEKP------------- 480

  Fly   395 SAHTSKECNRAMQKYRDKMR-----PLREPPKGGCRKQPTPVCKICNRKFTRKFFLEEHMNKAHL 454
              :..:||.:|. |:..|:.     .:.|.|   |:      |:.|.:.|.....|.:| ...|.
Human   481 --YKCEECGKAF-KWSSKLTVHKVIHMEEKP---CK------CEECGKAFKHFSALRKH-KIIHT 532

  Fly   455 NKRNFTCEICGANFYSQGTMQTHRKAVHLLVHT----VQCEVCDLTIKSKGNYRRH--------- 506
            .|:.:.||.||..|.:..|:..|:     ::||    .:||.|....|...:..||
Human   533 GKKPYKCEECGKAFNNSSTLMKHK-----IIHTGKKPYKCEECGKAFKQSSHLTRHKAIHTGEKP 592

  Fly   507 -----C-KSQSH-----KDNLVKFGKNNDKTKDSNRRKGARTTDEKLDI----EASSSTNTCMTS 556
                 | |:.:|     |..::..||...|.::..:.....:|..|.:|    |.......|..:
Human   593 YKCEECGKAFNHFSALRKHQIIHTGKKPYKCEECGKAFSQSSTLRKHEIIHTGEKPYKCEECGKA 657

  Fly   557 ANKSTHNYKKMGIKTKQTHLKTPCRSKKRVKIKICETCGNSIVGSMQRHYRSM-KHKL 613
            ...|:|..:...|.|::...|             ||.||.:.     .|:.:: |||:
Human   658 FKWSSHLTRHKVIHTEEKPYK-------------CEECGKAF-----NHFSALRKHKI 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8089	NP_611014.1	C2H2 Zn finger	289..309	CDD:275368	5/19 (26%)
		C2H2 Zn finger	322..343	CDD:275368	7/20 (35%)
		C2H2 Zn finger	355..376	CDD:275368	7/20 (35%)
		C2H2 Zn finger	432..453	CDD:275368	5/20 (25%)
		C2H2 Zn finger	461..486	CDD:275368	7/24 (29%)
		C2H2 Zn finger	490..506	CDD:275368	4/15 (27%)
ZNF99	NP_001073878.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368	0/1 (0%)
		C2H2 Zn finger	232..251	CDD:275368	6/36 (17%)
		C2H2 Zn finger	259..279	CDD:275368	7/55 (13%)
		COG5048	267..684	CDD:227381	116/557 (21%)
		zf-H2C2_2	272..296	CDD:290200	3/57 (5%)
		C2H2 Zn finger	287..307	CDD:275368	4/20 (20%)
		zf-H2C2_2	299..324	CDD:290200	8/38 (21%)
		C2H2 Zn finger	315..335	CDD:275368	4/19 (21%)
		zf-H2C2_2	327..352	CDD:290200	6/24 (25%)
		C2H2 Zn finger	343..363	CDD:275368	6/27 (22%)
		C2H2 Zn finger	371..391	CDD:275368	6/32 (19%)
		zf-H2C2_2	383..407	CDD:290200	8/28 (29%)
		C2H2 Zn finger	399..419	CDD:275368	5/19 (26%)
		C2H2 Zn finger	427..447	CDD:275368	7/27 (26%)
		C2H2 Zn finger	455..475	CDD:275368	7/20 (35%)
		zf-H2C2_2	467..491	CDD:290200	10/40 (25%)
		C2H2 Zn finger	483..503	CDD:275368	5/20 (25%)
		C2H2 Zn finger	511..531	CDD:275368	5/20 (25%)
		zf-H2C2_2	523..548	CDD:290200	9/25 (36%)
		COG5048	534..857	CDD:227381	41/187 (22%)
		C2H2 Zn finger	539..559	CDD:275368	7/24 (29%)
		zf-H2C2_2	552..576	CDD:290200	6/28 (21%)
		C2H2 Zn finger	567..587	CDD:275368	6/19 (32%)
		zf-H2C2_2	579..604	CDD:290200	4/24 (17%)
		C2H2 Zn finger	595..615	CDD:275368	4/19 (21%)
		zf-H2C2_2	607..632	CDD:290200	4/24 (17%)
		C2H2 Zn finger	623..643	CDD:275368	3/19 (16%)
		zf-H2C2_2	636..659	CDD:290200	4/22 (18%)
		C2H2 Zn finger	651..671	CDD:275368	3/19 (16%)
		zf-H2C2_2	663..688	CDD:290200	8/42 (19%)
		C2H2 Zn finger	679..699	CDD:275368	8/24 (33%)
		zf-H2C2_2	691..716	CDD:290200	3/7 (43%)
		C2H2 Zn finger	707..727	CDD:275368
		zf-H2C2_2	720..743	CDD:290200
		C2H2 Zn finger	735..755	CDD:275368
		C2H2 Zn finger	763..783	CDD:275368
		zf-H2C2_2	775..800	CDD:290200
		C2H2 Zn finger	791..811	CDD:275368
		C2H2 Zn finger	819..839	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142247
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930