DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8089 and BNC2

DIOPT Version :9

Sequence 1:	NP_611014.1	Gene:	CG8089 / 36679	FlyBaseID:	FBgn0033993	Length:	624	Species:	Drosophila melanogaster
Sequence 2:	NP_060107.3	Gene:	BNC2 / 54796	HGNCID:	30988	Length:	1099	Species:	Homo sapiens

Alignment Length:	206	Identity:	53/206 - (25%)
Similarity:	76/206 - (36%)	Gaps:	47/206 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 SAHTSKECNRAMQK------YRDKMRPLR---------EPPKGGCRKQPTPVCKICNRKFTRKFF 444
            |..|..|.|.:.:.      |::...|.|         ||     :.:|..|..|.|........
Human   356 SLSTQNEYNESSESEVSPTPYKNDQTPNRNALTSITNVEP-----KTEPACVSPIQNSAPVSDLT 415

  Fly   445 LEEH------------MNKAHLNKRNFTCEICGANFYSQGTMQTHRKAVHLLV-HTVQCEVCDLT 496
            ..||            |..|....|.| |..||..||.:||::.|..||||.: |....|.|::.
Human   416 KTEHPKSSFRIHRMRRMGSASRKGRVF-CNACGKTFYDKGTLKIHYNAVHLKIKHRCTIEGCNMV 479

  Fly   497 IKSKGNYRRHCKSQSHKDNLVKFGKNNDKTKDSNR-RKGARTTDEKLDIEASSSTNTCMTSANKS 560
            ..|..:..||..:.:.:.::.....|.|  ||..| ..||.|     .:.||:.:|..:||..:
Human   480 FSSLRSRNRHSANPNPRLHMPMLRNNRD--KDLIRATSGAAT-----PVIASTKSNLALTSPGR- 536

  Fly   561 THNYKKMGIKT 571
                ..||..|
Human   537 ----PPMGFTT 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8089	NP_611014.1	C2H2 Zn finger	289..309	CDD:275368
		C2H2 Zn finger	322..343	CDD:275368
		C2H2 Zn finger	355..376	CDD:275368
		C2H2 Zn finger	432..453	CDD:275368	5/32 (16%)
		C2H2 Zn finger	461..486	CDD:275368	12/25 (48%)
		C2H2 Zn finger	490..506	CDD:275368	3/15 (20%)
BNC2	NP_060107.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..385		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..423		6/25 (24%)
		C2H2 Zn finger	443..464	CDD:275368	9/20 (45%)
		C2H2 Zn finger	471..489	CDD:275368	3/17 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..641
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	648..742
		C2H2 Zn finger	835..856	CDD:275368
		C2H2 Zn finger	863..881	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	929..948
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	968..1008
		C2H2 Zn finger	1037..1058	CDD:275368
		C2H2 Zn finger	1065..1083	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1079..1099
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7987
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950